Safety, inhibition of platelet aggregation and pharmacokinetics of Fab'2 fragments of the anti-glycoprotein IIb-IIIa monoclonal antibody FRaMon in high-risk coronary angioplasty.

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00

abstract：:Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measu...

journal_title：Platelets

authors： García-Guerra R,Mateo CR,García-Muñoz MS,Zapata MA,Plaza I,González-Rodríguez J

更新日期：1998-01-01 00:00:00

abstract：:This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 d...

journal_title：Platelets

authors： Palma-Barqueros V,Ruiz-Pividal J,Bohdan N,Vicente V,Bastida JM,Lozano M,Rivera J

更新日期：2019-01-01 00:00:00

abstract：:We have investigated interactions between human blood platelets and the vitronectin-containing fluid-phase terminal complement complex, the SC5b-9, which is a non-cytolytic variant of the membrane attack complex C%9(m). SC5b-9 affinity for the platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) complex was demonstrat...

journal_title：Platelets

authors： Røger M,Høgåsen K,Holme PA,Halstensen TS,Mollnes TE,Hovig T

更新日期：1995-01-01 00:00:00

abstract：:Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...

journal_title：Platelets

authors： Gende OA

更新日期：2005-11-01 00:00:00

abstract：:Thrombocytopenia is common in the neonatal intensive care unit. Transfusion of platelets is often required. The purpose of our study was to determine changes in thrombopoietin (Tpo) following transfusion of platelets in preterm neonates. Preterm neonates undergoing platelet transfusion were randomized to receive a tra...

journal_title：Platelets

authors： Kline A,Mackley A,Taylor SM,McKenzie SE,Paul DA

更新日期：2008-09-01 00:00:00

abstract：:Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

journal_title：Platelets

authors： Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

更新日期：2009-05-01 00:00:00

abstract：:We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. Th...

journal_title：Platelets

authors： Zhao H,Du W,Wang D,Gu D,Xue F,Ge J,Sui T,Yang R

更新日期：2010-01-01 00:00:00

abstract：:The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...

journal_title：Platelets

authors： Li J,Li Y,Ouyang J,Zhang F,Liang C,Ye Z,Chen S,Cheng J

更新日期：2020-08-17 00:00:00

abstract：:The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse w...

journal_title：Platelets

authors： Al Ghaithi R,Mori J,Nagy Z,Maclachlan A,Hardy L,Philippou H,Hethershaw E,Morgan NV,Senis YA,Harrison P

更新日期：2019-01-01 00:00:00

abstract：:Platelets are involved in host defense via clearance of bacteria from the circulation, interaction with virus particles, and uptake of various size particulates. There is a growing interest in micro- and nanoparticles for drug delivery and there is evidence that the properties of these particles critically influence t...

journal_title：Platelets

authors： Gupalo E,Kuk C,Qadura M,Buriachkovskaia L,Othman M

更新日期：2013-01-01 00:00:00

abstract：:Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...

journal_title：Platelets

authors： Vila PM,Zafar MU,Badimon JJ

更新日期：2009-12-01 00:00:00

abstract：:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were...

journal_title：Platelets

authors： Zhao P,Hou M,Liu Y,Liu HX,Huang RB,Yao HX,Niu T,Peng J,Jiang M,Han YQ,Hu JD,Zhou H,Zhou ZP,Qiu L,Zhang LS,Wang X,Wang HQ,Feng R,Yang LH,Ma LM,Wang SQ,Kong PY,Wang WS,Sun HP,Sun J,Zhou HB,Zhu TN,Wang

更新日期：2020-07-02 00:00:00

abstract：:Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor could impact the dis...

journal_title：Platelets

authors： Rabani V,Montange D,Meneveau N,Davani S

更新日期：2018-11-01 00:00:00

abstract：:Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...

journal_title：Platelets

authors： Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

更新日期：2019-01-01 00:00:00

abstract：:Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...

journal_title：Platelets

authors： Finsterbusch M,Schrottmaier WC,Kral-Pointner JB,Salzmann M,Assinger A

更新日期：2018-11-01 00:00:00

abstract：:Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or ...

journal_title：Platelets

authors： Toya T,Yoshimi A,Morioka T,Arai S,Ichikawa M,Usuki K,Kurokawa M

更新日期：2014-01-01 00:00:00

abstract：:A hypercoagulable state has, in observational studies, been associated with increased risk of thromboembolic events. The aim of this trial was to study whether dual antiplatelet therapy (DAPT) with clopidogrel in addition to aspirin could reduce the rate of graft occlusions, thromboembolic events, and death compared t...

journal_title：Platelets

authors： Rafiq S,Johansson PI,Kofoed KF,Lund JT,Olsen PS,Bentsen S,Steinbrüchel DA

更新日期：2017-12-01 00:00:00

abstract：:In adults with immune thrombocytopenic purpura (ITP), steroids are usually proposed as first-line therapy, but long-term complete responses are obtained in no more than 20% of patients. For the remaining patients, splenectomy is considered the treatment of choice, with reported "cure" rates from 60-70%. However, the i...

journal_title：Platelets

authors： Vancine-Califani SM,De Paula EV,Ozelo MC,Orsi FL,Fabri DR,Annichino-Bizzacchi JM

更新日期：2008-11-01 00:00:00

abstract：:The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...

journal_title：Platelets

authors： Meyer T,Amaya M,Desai H,Robles-Carrillo L,Hatfield M,Francis JL,Amirkhosravi A

更新日期：2010-01-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...

journal_title：Platelets

authors： Michaud V,Fiore M,Coste V,Huguenin Y,Bordet JC,Plaisant C,Lasseaux E,Morice-Picard F,Arveiler B

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Low-grade inflammatory status was thought to be a major underlying mechanism in MetS. White blood cell (WBC) count was one of the inflammatory markers identified to be associated with MetS. Moreover, not only WBC but also hemoglobin (Hb) and platelet (PLT) were all associated with MetS. OBJECTIVE:In this st...

journal_title：Platelets

authors： Liu H,Hsu CH,Lin JD,Hsieh CH,Lian WC,Wu CZ,Pei D,Chen YL

更新日期：2014-01-01 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...

journal_title：Platelets

authors： Breimo ES,Østerud B

更新日期：2003-11-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:Previous investigations from our laboratory identified the ultrastructural pathology and cytochemistry of macrothrombocytes (MTC) from patients with the X-linked, G208S varient of the GATA-1 mutation.A subsequent biochemical study of the MTC cytoskeletal proteins using polyacrylamide gel electrophoresis and western bl...

journal_title：Platelets

authors： White JG,Burris SM,Crowe BR

更新日期：2009-05-01 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...

journal_title：Platelets

authors： Mathai J,Resmi KR,Sulochana PV,Sathyabhama S,Baby Saritha G,Krishnan LK

更新日期：2006-09-01 00:00:00

abstract：:The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...

journal_title：Platelets

authors： White JG,Kumar A,Hogan MJ

更新日期：2006-12-01 00:00:00

abstract：:We prospectively investigated the prevalence of Helicobacter pylori (H. pylori) infection in a cohort of 54 adult Serbian patients with chronic idiopathic thrombocytopenic purpura (ITP), and examined the effects of its eradication on their platelet counts. H. pylori infection was diagnosed in 39/54 (72.2%) patients, u...

journal_title：Platelets

authors： Suvajdzić N,Stanković B,Artiko V,Cvejić T,Bulat V,Bakrac M,Colović M,Obradović V,Atkinson HD

更新日期：2006-06-01 00:00:00