Abstract:
:We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. The expression of IFN-gamma was higher, while the expression of IL-4 was notably lower in ITP patients when compared with the controls. Most importantly, the Th1/Th2 (IFN-gamma/IL-4) was remarkably higher in ITP patients, showing that the ITP patients were mainly in the Th1 polarization response. Although the methylation rate of CpGs located at -409 of perforin was higher (p = 0.0376) and that of IFN-gamma were relatively higher (p = 0.0582) in ITP, we did not find the negative correlation between the expression of those genes and the methylation of their promoters.
journal_name
Plateletsjournal_title
Plateletsauthors
Zhao H,Du W,Wang D,Gu D,Xue F,Ge J,Sui T,Yang Rdoi
10.3109/09537100903420277subject
Has Abstractpub_date
2010-01-01 00:00:00pages
137-43issue
2eissn
0953-7104issn
1369-1635journal_volume
21pub_type
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