Abstract:
:Thrombocytopenia is common in the neonatal intensive care unit. Transfusion of platelets is often required. The purpose of our study was to determine changes in thrombopoietin (Tpo) following transfusion of platelets in preterm neonates. Preterm neonates undergoing platelet transfusion were randomized to receive a transfusion volume of either 10 or 15 ml/kg. Blood was obtained for Tpo measurement pre-transfusion, one and 24 hours post-transfusion. Platelet Factor 4 (PF4) was also measured to quantify platelet activation. Statistical analysis was performed using repeated measures ANOVA, and Mann-Whitney U test as appropriate. Ten infants were enrolled in each group. Gestational age, birth weight, etiology of thrombocytopenia, and timing of transfusion did not differ between the 10 and 15 ml/kg groups. There were no differences between the groups in platelet count prior to and/or following transfusion. Both transfusion volumes were equally well tolerated. Tpo and PF4 did not differ between groups at any of the study time points. When both groups were analysed together, Tpo dropped 43% (95% confidence 37-49%, p = 0.01) 1-hour post compared to pre-transfusion. In conclusion the observed decrease in Tpo following platelet transfusion suggests that Tpo kinetics in neonates is similar to adults following transfusion. PF4 was not affected by transfusion. There was not an increase in platelet count following transfusion volume of 15 ml/kg compared to 10 ml/kg.
journal_name
Plateletsjournal_title
Plateletsauthors
Kline A,Mackley A,Taylor SM,McKenzie SE,Paul DAdoi
10.1080/09537100802220476subject
Has Abstractpub_date
2008-09-01 00:00:00pages
428-31issue
6eissn
0953-7104issn
1369-1635pii
904262860journal_volume
19pub_type
杂志文章,随机对照试验相关文献
PLATELETS文献大全abstract::Catastrophic antiphospholipid syndrome (CAPS) involves sudden multiorgan dysfunction from thrombosis due to antibodies that cause platelet activation and endothelial dysfunction. Treatment variably combines anticoagulation, corticosteroid use, therapeutic plasma exchange (TPE), and high-dose intravenous immunoglobulin...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1802414
更新日期:2020-08-07 00:00:00
abstract::In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100050057657
更新日期:2000-06-01 00:00:00
abstract::We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. Th...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903420277
更新日期:2010-01-01 00:00:00
abstract::Selective activation of the platelet TXA2 receptor is sufficient to mediate concurrent aggregation, deaggregation and shape change (SC) responses without activation of known Gi-coupled receptors (Platelets 2003; 14: 89). However, Gi-coupled receptor activation strongly influences the hemostasis response in vivo. This ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100310001612380
更新日期:2003-09-01 00:00:00
abstract::The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701694144
更新日期:2008-03-01 00:00:00
abstract::SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109109005512
更新日期:1991-01-01 00:00:00
abstract::Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm3) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adul...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1293802
更新日期:2017-11-01 00:00:00
abstract::Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...
journal_title:Platelets
pub_type: 临床试验,杂志文章
doi:10.3109/09537104.2011.589014
更新日期:2012-01-01 00:00:00
abstract::SIRT1, a class III histone deacetylase, is critically involved in cellular response to stress and modulates cardiovascular risk factors. However, its role in thrombus formation is largely unknown. Thus, this study investigated the effect of SIRT1 on pulmonary thrombus formation, and then identified its role in the mod...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1190005
更新日期:2016-12-01 00:00:00
abstract::Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1430358
更新日期:2018-11-01 00:00:00
abstract::The ram gene was isolated from a rat megakaryocyte cDNA library and encodes a GTP-binding protein with a Mr of 25 000. In order to clarify the presence of the ram protein (ram p25) in human platelets, we tried to purify ram p25 from the sodium cholate extract of human platelet membranes by a combination of DEAE-Sephac...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109309013227
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Low-grade inflammatory status was thought to be a major underlying mechanism in MetS. White blood cell (WBC) count was one of the inflammatory markers identified to be associated with MetS. Moreover, not only WBC but also hemoglobin (Hb) and platelet (PLT) were all associated with MetS. OBJECTIVE:In this st...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2013.780017
更新日期:2014-01-01 00:00:00
abstract::Collagen (5 microg/ml) stimulation of washed platelets increased endogenous serotonin (5-HT) release to the medium from 13.88 1.39 to 188.67 26.37 pmol/108 platelets ( P < 0.001). Adrenaline (16 microM) also increased 5-HT release, from 11.0 1.46 to 110.6 29.9 pmol/108 platelets ( P < 0.02). Naftopidil enhanced collag...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109777519
更新日期:1997-01-01 00:00:00
abstract::The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.3109/09537104.2013.843072
更新日期:2014-01-01 00:00:00
abstract::In adults with immune thrombocytopenic purpura (ITP), steroids are usually proposed as first-line therapy, but long-term complete responses are obtained in no more than 20% of patients. For the remaining patients, splenectomy is considered the treatment of choice, with reported "cure" rates from 60-70%. However, the i...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802315110
更新日期:2008-11-01 00:00:00
abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1492105
更新日期:2018-12-01 00:00:00
abstract::Whether the simultaneous administration of ciprofloxacin or tazobactam/piperacillin increases the risk of thrombocytosis is unknown. Broncho-pulmonary infection in a 50-year-old male with acute, hypertensive, intracerebral bleeding, necessitated therapy with cefpirome (2 g/day, 6 days), ciprofloxacin (800 mg/d, 11 day...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100310001594543
更新日期:2003-08-01 00:00:00
abstract::Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100310001644024
更新日期:2004-02-01 00:00:00
abstract::We measured and compared the levels of microparticles, chemokines, cell adhesion molecules and platelet activation markers with a view to developing a better understanding of their potential contributions to the pathophysiology of progressive systemic sclerosis (PSS, scleroderma). The concentrations of all the factors...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701882038
更新日期:2008-05-01 00:00:00
abstract::We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537101003612813
更新日期:2010-01-01 00:00:00
abstract::Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The rela...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109509023564
更新日期:1995-01-01 00:00:00
abstract::Photochemical treatment (PCT) of platelet concentrates, using amotosalen HCl and UVA-light, inactivates pathogens by forming adducts between amotosalen and nucleic acids. The impact of the photochemical treatment on pathogens and leukocytes has been studied extensively. Yet little is known about the effect of PCT on n...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500129300
更新日期:2005-12-01 00:00:00
abstract::Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...
journal_title:Platelets
pub_type: 杂志文章,meta分析
doi:10.1080/09537104.2018.1543864
更新日期:2019-01-01 00:00:00
abstract::Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701609019
更新日期:2007-12-01 00:00:00
abstract::Two putative substitutes for fresh endothelial cell (EC) extracellular matrix (ECM), frozen ECM and Matrigel, were studied using a parallel-plate perfusion system and platelet deposition was evaluated morphometrically. Coverslips covered with ECM were stored frozen at-30 C for 0 (fresh ECM), 1, 2, 3 or 4 weeks. The ab...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109876500
更新日期:1998-01-01 00:00:00
abstract::Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2016.1265925
更新日期:2017-05-01 00:00:00
abstract::Binding of podoplanin to the C-type lectin-like receptor 2 (CLEC-2) promotes platelet activation and soluble CLEC-2 (sCLEC-2) is shed from activated platelets. The role of sCLEC-2 in the plasma is unknown. The expression level and plasma concentration of sCLEC-2 could be affected by variants of the corresponding gene,...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1849601
更新日期:2020-11-29 00:00:00
abstract::Adrenaline is a platelet activator having a resting plasma concentration of <1 nmol/l that increases to a few nmol/l during stress. However, most in vitro assays only detect effects of adrenaline in micromolar concentrations. This makes it difficult to estimate the relevance of in vitro data for the in vivo situation....
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.672780
更新日期:2013-01-01 00:00:00
abstract::Platelet shape change is an extremely rapid process mediated by both the calcium-sensitive and p160ROCK pathways. The present study examines how different features of shape change studied by scanning electron microscopy clearly correlate to changes in the pattern of light absorbance measured in an aggregometer. Platel...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953710031000092794
更新日期:2003-05-01 00:00:00
abstract::Mechanisms involved in the reduction of blood platelet functions by various plant extract, including the grape seeds extract (rich in phenolic compounds, a mixture of about 95% oligomeric phenols; GSE) are still unclear. In the literature there are few papers describing studies on the effects of GSE on selected elemen...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.618562
更新日期:2012-01-01 00:00:00