Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age.

abstract：:SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...

journal_title：Platelets

authors： Margalit A,Livne AA

更新日期：1991-01-01 00:00:00

abstract：:Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...

journal_title：Platelets

authors： Schrottmaier WC,Kral JB,Zeitlinger M,Salzmann M,Jilma B,Assinger A

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...

journal_title：Platelets

authors： Olas B,Wachowicz B,Tomczak A,Erler J,Stochmal A,Oleszek W

更新日期：2008-02-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been...

journal_title：Platelets

authors： Laursen MA,Larsen JB,Hvas AM

更新日期：2018-05-01 00:00:00

abstract：:Platelets from patients with type 2 diabetes show abnormalities in intracellular Ca(2+) homeostasis that are involved in platelet hyperaggregability and the development of thrombotic complications. Different Ca(2+) transport mechanisms have been reported to be altered in platelets from patients with type 2 diabetes, i...

journal_title：Platelets

authors： Zbidi H,Jardin I,Bartegi A,Salido GM,Rosado JA

更新日期：2011-01-01 00:00:00

abstract：:Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes. The effect of P2Y12 inhibitors on pro-coagulatory, phosphatidylserine (PS)-expressing EV has been investigated previously, but onl...

journal_title：Platelets

authors： Haller PM,Stojkovic S,Piackova E,Andric T,Wisgrill L,Spittler A,Wojta J,Huber K,Jäger B

更新日期：2020-05-18 00:00:00

abstract：:We have investigated interactions between human blood platelets and the vitronectin-containing fluid-phase terminal complement complex, the SC5b-9, which is a non-cytolytic variant of the membrane attack complex C%9(m). SC5b-9 affinity for the platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) complex was demonstrat...

journal_title：Platelets

authors： Røger M,Høgåsen K,Holme PA,Halstensen TS,Mollnes TE,Hovig T

更新日期：1995-01-01 00:00:00

abstract：:The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result of opposing mechanisms that lead to both enhancement and inhibition of platelet function. Enhancement of platelet function is known to be via EP3 receptors linked to G(i) and inhibition of adenylyl cyclase. However, the recep...

journal_title：Platelets

authors： Iyú D,Glenn JR,White AE,Johnson AJ,Fox SC,Heptinstall S

更新日期：2010-01-01 00:00:00

abstract：:Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...

journal_title：Platelets

authors： Gokalp D,Tuzcu A,Bahceci M,Ayyildiz O,Erdemoglu M,Alpagat G

更新日期：2011-01-01 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:The potential roles of serum butyrylcholinesterase (BChE) activity and platelet indices in type 1 diabetes (T1D) remain uncertain. We aimed to investigate the correlation among the platelet indices, serum BChE activity, and diabetic ketoacidosis (DKA). Sixty-one T1D patients, 29 patients with DKA, and 30 age- and sex-...

journal_title：Platelets

authors： Ma SG,Yang LX,Qiu XQ

更新日期：2013-01-01 00:00:00

abstract：:The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis. Our study aimed to establish a flow cytometry (FC) method for the measure...

journal_title：Platelets

authors： Gerhards C,Uhlig S,Etemad M,Christodoulou F,Bieback K,Klüter H,Bugert P

更新日期：2020-07-03 00:00:00

abstract：:Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender,...

journal_title：Platelets

authors： Berlin G,Hammar M,Tapper L,Tynngård N

更新日期：2019-01-01 00:00:00

abstract：:Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or '...

journal_title：Platelets

authors： Gachet C,Hechler B,Léon C,Vial C,Ohlmann P,Cazenave JP

更新日期：1996-01-01 00:00:00

abstract：:Platelets play a key role in thrombotic vascular occlusion at the side of an atherosclerotic plaque. Malondialdehyde (MDA) derivatives are components of oxidized LDL. Recent studies suggest enhanced adhesion of platelets on oxidized LDL, but evidence of MDA-modified LDL contribution to enhanced platelet adhesion is mi...

journal_title：Platelets

authors： Suttnar J,Otáhalová E,Cermák J,Dyr JE

更新日期：2006-03-01 00:00:00

abstract：:Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or ...

journal_title：Platelets

authors： Toya T,Yoshimi A,Morioka T,Arai S,Ichikawa M,Usuki K,Kurokawa M

更新日期：2014-01-01 00:00:00

abstract：:Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The rela...

journal_title：Platelets

authors： Bakken AM,Hervig T,Thorsen T,Holmsen H

更新日期：1995-01-01 00:00:00

abstract：:Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between platelets in ITP and oxidative stress has not yet been addressed. The int...

journal_title：Platelets

authors： Kamhieh-Milz J,Bal G,Sterzer V,Kamhieh-Milz S,Arbach O,Salama A

更新日期：2012-01-01 00:00:00

abstract：:Platelets are involved in host defense via clearance of bacteria from the circulation, interaction with virus particles, and uptake of various size particulates. There is a growing interest in micro- and nanoparticles for drug delivery and there is evidence that the properties of these particles critically influence t...

journal_title：Platelets

authors： Gupalo E,Kuk C,Qadura M,Buriachkovskaia L,Othman M

更新日期：2013-01-01 00:00:00

abstract：:Measurement of platelet aggregation in platelet-rich plasma (PRP) is a fundamental tool in platelet studies, despite the fact that the technique required for this is time-consuming, may need large volumes of blood, and require particular skill and special equipment. The use of a microplate reader seems useful to perfo...

journal_title：Platelets

authors： Krause S,Scholz T,Temmler U,Lösche W

更新日期：2001-11-01 00:00:00

abstract：:In previous studies we have shown that relaxin (RLX), a peptide hormone produced predominantly during pregnancy, is a powerful inhibitor of platelet aggregation. The current study shows that RLX, given systemically to rats, also affects the number of circulating platelets and their release by spleen megakaryocytes. Ma...

journal_title：Platelets

authors： Bani D,Maurizi M,Bigazzi M

更新日期：1995-01-01 00:00:00

abstract：:The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...

journal_title：Platelets

authors： Li J,Li Y,Ouyang J,Zhang F,Liang C,Ye Z,Chen S,Cheng J

更新日期：2020-08-17 00:00:00

abstract：:Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study comp...

journal_title：Platelets

authors： Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KG

更新日期：2020-12-26 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 d...

journal_title：Platelets

authors： Palma-Barqueros V,Ruiz-Pividal J,Bohdan N,Vicente V,Bastida JM,Lozano M,Rivera J

更新日期：2019-01-01 00:00:00

abstract：:The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...

journal_title：Platelets

authors： Meyer T,Amaya M,Desai H,Robles-Carrillo L,Hatfield M,Francis JL,Amirkhosravi A

更新日期：2010-01-01 00:00:00

abstract：:In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from seco...

journal_title：Platelets

authors： Rejtö L,Schlammadinger A,László P,Kiss A,Telek B,Boda Z

更新日期：2000-02-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the re...

journal_title：Platelets

authors： Kubesch A,Barbeck M,Al-Maawi S,Orlowska A,Booms PF,Sader RA,Miron RJ,Kirkpatrick CJ,Choukroun J,Ghanaati S

更新日期：2019-01-01 00:00:00