Reduced antioxidant capacities in platelets from patients with autoimmune thrombocytopenia purpura (ITP).

abstract：:The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result of opposing mechanisms that lead to both enhancement and inhibition of platelet function. Enhancement of platelet function is known to be via EP3 receptors linked to G(i) and inhibition of adenylyl cyclase. However, the recep...

journal_title：Platelets

authors： Iyú D,Glenn JR,White AE,Johnson AJ,Fox SC,Heptinstall S

更新日期：2010-01-01 00:00:00

abstract：:Platelet aggregation in response to ADP, adrenaline, collagen, arachidonic acid and ristocetin was measured in a large population of healthy Saudi males (n = 393) and females (n = 221) whose age ranged from 11-60 years. The number of observations ranged from 130 for one of the doses of ristocetin (1.0 g/l) to 554 for ...

journal_title：Platelets

authors： Gader AM,Bahakim HM,Malaika SS

更新日期：1990-01-01 00:00:00

abstract：:Cell-cell and cell-extracellular matrix interactions are mediated by a number of membrane glycoproteins. On the basis of structural homologies, several families of cell adhesion molecules (integrins, selectins, immunoglobulins, cadherins, leucine-rich glycoproteins) have been established. Since 1991, a new family of C...

journal_title：Platelets

authors： Daviet L,McGregor JL

更新日期：1996-01-01 00:00:00

abstract：:No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

journal_title：Platelets

authors： Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

更新日期：2010-01-01 00:00:00

abstract：:In the presence of large bone defects, delayed bone union, or nonunion and fractures, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates (APCs). Due to the high content of platelets and platelet-derived bioactive...

journal_title：Platelets

authors： Marcazzan S,Taschieri S,Weinstein RL,Del Fabbro M

更新日期：2018-06-01 00:00:00

abstract：:A hypercoagulable state has, in observational studies, been associated with increased risk of thromboembolic events. The aim of this trial was to study whether dual antiplatelet therapy (DAPT) with clopidogrel in addition to aspirin could reduce the rate of graft occlusions, thromboembolic events, and death compared t...

journal_title：Platelets

authors： Rafiq S,Johansson PI,Kofoed KF,Lund JT,Olsen PS,Bentsen S,Steinbrüchel DA

更新日期：2017-12-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:Adrenaline is a platelet activator having a resting plasma concentration of <1 nmol/l that increases to a few nmol/l during stress. However, most in vitro assays only detect effects of adrenaline in micromolar concentrations. This makes it difficult to estimate the relevance of in vitro data for the in vivo situation....

journal_title：Platelets

authors： Eriksson AC,Whiss PA

更新日期：2013-01-01 00:00:00

abstract：:The action of inorganic forms of selenium (Se) on blood platelet aggregation, secretion and the arachidonate pathway in vitro was studied. It was shown that sodium selenite, after 30 min preincubation, inhibited platelet aggregation induced by 0.1 U/ml of thrombin and by 10 microM ADP (about 30% inhibition of aggregat...

journal_title：Platelets

authors： Zbikowska HM,Wachowicz B,Krajewski T

更新日期：1999-01-01 00:00:00

abstract：:The aim of this survey was to describe drug-induced immune thrombocytopenia (ITP) reported in the French PharmacoVigilance database (FPVD) and to discuss the drugs involved. The request to the FPVD used the seven most accurate diagnosis codes to identify ITP. The study was restricted to cases reported from 2007 to 201...

journal_title：Platelets

authors： Moulis G,Sommet A,Sailler L,Lapeyre-Mestre M,Montastruc JL,French Association Of Regional Pharmacovigilance Centers.

更新日期：2012-01-01 00:00:00

abstract：:The isolation of mitochondria is gaining importance in experimental and clinical laboratory settings. The mitochondrion is known as the powerhouse of the cell as it produces the energy to power most cellular functions but is also involved in many cellular processes. Of interest, mitochondria and mitochondrial componen...

journal_title：Platelets

authors： Léger JL,Jougleux JL,Savadogo F,Pichaud N,Boudreau LH

更新日期：2020-01-01 00:00:00

abstract：:The generation of superoxide anion radicals (O2*-) and the other reactive oxygen species (ROS) was estimated by means of cytochrome c reduction and chemiluminescence, as well in resting blood platelets and in platelets stimulated by thrombin in the presence or absence of some inhibitors of pathways involved in platele...

journal_title：Platelets

authors： Wachowicz B,Olas B,Zbikowska HM,Buczyński A

更新日期：2002-05-01 00:00:00

abstract：:Adenosine diphosphate (ADP) is recognized as an important mediator of platelet aggregation. Transient aggregation at low (< or =1 microM), and sustained aggregation at higher ADP concentrations are consistently observed. Dissociation of platelet aggregates has been described and may explain the reversible component of...

journal_title：Platelets

authors： Maayani S,Tagliente TM,Schwarz T,Craddock-Royal B,Alcala C,Marrero G,Martinez R

更新日期：2001-08-01 00:00:00

abstract：:Patients with peripheral artery disease (PAD) following peripheral percutaneous transluminal angioplasty (PTA) with stent implantation are prone to stent thrombosis despite treatment with aspirin and clopidogrel. Impaired clopidogrel responsiveness is associated with increased risk of ischemic events in patients follo...

journal_title：Platelets

authors： Mazur P,Frołow M,Niżankowski R,Sadowski J,Undas A

更新日期：2013-01-01 00:00:00

abstract：:A major challenge in the use of artificial materials for implant devices, artificial organs, and extra-corporeal circulation systems, is the adhesion of platelets and the subsequent formation of platelet aggregates on the non-biological surface. The mechanism of platelet attachment to artificial surfaces is not comple...

journal_title：Platelets

authors： Røger M,Høgåsen K,Mollnes TE,Hovig T

更新日期：1994-01-01 00:00:00

abstract：:The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...

journal_title：Platelets

authors： Zisk JL,Mackley A,Clearly G,Chang E,Christensen RD,Paul DA

更新日期：2014-01-01 00:00:00

abstract：:Human melanoma cell Line, HMV-I, has been shown to induce platelet aggregation without thrombin generation. The platelet-aggregating activity of HMV-I cells increased with increasing culture periods of the cells. However, data indicate that the platelet-aggregating activity of HMV-I cells is dependent upon the cell de...

journal_title：Platelets

authors： Katagiri Y,Hayashi Y,Baba I,Yamazaki H,Tanoue K

更新日期：1995-01-01 00:00:00

abstract：:Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...

journal_title：Platelets

authors： Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

更新日期：2019-01-01 00:00:00

abstract：:Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

journal_title：Platelets

authors： Chen Y,Yang Y,Cheng J,Lu J,Hu W

更新日期：2020-01-01 00:00:00

abstract：:Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. T...

journal_title：Platelets

authors： Au AE,Josefsson EC

更新日期：2017-06-01 00:00:00

abstract：:Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...

journal_title：Platelets

authors： Rubak P,Nissen PH,Kristensen SD,Hvas AM

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:Although (very) late coronary stent thrombosis is a rare complication after percutaneous coronary interventions (PCI), its consequences are devastating with a high morbidity and mortality. Previous studies have identified several clinical, procedural and angiographic characteristics that are associated with stent thro...

journal_title：Platelets

authors： Zwart B,Van Kerkvoorde TC,van Werkum JW,Breet NJ,Ten Berg JM,Van 't Hof AW

更新日期：2010-01-01 00:00:00

abstract：:Platelet aggregation and microaggregate formation were measured in samples of stirred whole blood by flow cytometry. Blood samples were stirred in a multi-sample agitator with ADP, fixed and labelled with a platelet-specific CD42a-FITC fluorescent antibody. The blood was then diluted and applied directly to a flow cyt...

journal_title：Platelets

authors： Fox SC,Sasae R,Janson S,May JA,Heptinstall S

更新日期：2004-03-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:ADP induces platelet aggregation in human whole blood and platelet-rich plasma (PRP). ATP induces aggregation in whole blood only; this involves leukocytes and is mediated by ADP. Here we studied ATP- and ADP-induced aggregation in patients with raised leukocyte counts (mean 46.2x10(3) leukocytes/microl). Platelet agg...

journal_title：Platelets

authors： Glenn JR,White AE,Johnson A,Fox SC,Behan MW,Dolan G,Heptinstall S

更新日期：2005-05-01 00:00:00

abstract：:In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...

journal_title：Platelets

authors： Unterberger U,Eichelberger B,Ulz A,Panzer S

更新日期：2017-06-01 00:00:00

abstract：:The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...

journal_title：Platelets

authors： Vijapurkar M,Ghosh K,Shetty S

更新日期：2009-02-01 00:00:00

abstract：:Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...

journal_title：Platelets

authors： Laroche M,Dunois C,Vissac AM,Amiral J

更新日期：2017-05-01 00:00:00

abstract：:Erythropoietin (EPO) enhances formation of red blood cells and also affects thrombopoiesis and platelet function. We hypothesized that the effect of EPO may be reflected by changes in thromboxane B2 (TXB2) and endothelial cell function. Six male and six female subjects received recombinant human epoetin alpha (Erypo®)...

journal_title：Platelets

authors： Heinisch BB,Vcelar B,Kapiotis S,Blann A,Wolzt M,Siller-Matula JM,Jilma B

更新日期：2012-01-01 00:00:00