Transfusing neonates based on platelet count vs. platelet mass: a randomized feasibility-pilot study.

abstract：:We previously reported that thrombin-induced Ca(2+) mobilization was enhanced in aged rat platelets. Since Ca(2+) mobilization in platelets is believed to be closely associated with platelet activation, we examined Ca(2+) mobilization and the aggregatory response to ADP and thrombin in young (3 months) and aged (24 mo...

journal_title：Platelets

authors： Sugidachi A,Asai F,Oshima T,Koike H

更新日期：1995-01-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:Although (very) late coronary stent thrombosis is a rare complication after percutaneous coronary interventions (PCI), its consequences are devastating with a high morbidity and mortality. Previous studies have identified several clinical, procedural and angiographic characteristics that are associated with stent thro...

journal_title：Platelets

authors： Zwart B,Van Kerkvoorde TC,van Werkum JW,Breet NJ,Ten Berg JM,Van 't Hof AW

更新日期：2010-01-01 00:00:00

abstract：:Flow cytometric analysis of human platelets from healthy volunteers by high-resolution immunophenotyping accomplished with enzymatic amplification staining revealed the expression of CD34. Assessment of the platelets with five different monoclonal antibodies to the three different classes of CD34 epitopes suggested th...

journal_title：Platelets

authors： Lewandowska K,Kaplan D,Husel W

更新日期：2003-03-01 00:00:00

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00

abstract：:The association of chronic idiopathic thrombocytopenic purpura (cITP) and thyroid autoimmune diseases (TAD) is a known but an uncommon condition. Celiac disease (CD), which is characterized by malabsorption and villous atrophy that occur as a consequence of the ingestion of wheat gluten may also be related to other au...

journal_title：Platelets

authors： Altintas A,Pasa S,Cil T,Bayan K,Gokalp D,Ayyildiz O

更新日期：2008-06-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:To study the possibility of using thrombin generation tests in platelet-rich and platelet-poor plasma for evaluation of dual antiplatelet therapy efficacy in patients with coronary artery disease (CAD), following percutaneous coronary intervention. Venous blood was analyzed from CAD patients aged 53-75 years who had u...

journal_title：Platelets

authors： Berezovskaya G,Smirnova O,Malev E,Khromov-Borisov N,Klokova E,Karpenko M,Papayan L,Petrishchev N

更新日期：2018-03-01 00:00:00

abstract：:Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in atherosclerosis, there exists an increased risk for i...

journal_title：Platelets

authors： Przyborowski K,Kassassir H,Wojewoda M,Kmiecik K,Sitek B,Siewiera K,Zakrzewska A,Rudolf AM,Kostogrys R,Watala C,Zoladz JA,Chlopicki S

更新日期：2017-11-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...

journal_title：Platelets

authors： Pennings GJ,Yong AS,Wong C,Al-Tamimi M,Gardiner EE,Andrews RK,Kritharides L

更新日期：2014-01-01 00:00:00

abstract：:Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation, whereas GPIbα decreases due to ectodomain shedding. As an important...

journal_title：Platelets

authors： Hosseini E,Ghasemzadeh M,Nassaji F,Jamaat ZP

更新日期：2017-07-01 00:00:00

abstract：:The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...

journal_title：Platelets

authors： Vijapurkar M,Ghosh K,Shetty S

更新日期：2009-02-01 00:00:00

abstract：:Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...

journal_title：Platelets

authors： Ngo ATP,Sheriff J,Rocheleau AD,Bucher M,Jones KR,Sepp AI,Malone LE,Zigomalas A,Maloyan A,Bahou WF,Bluestein D,McCarty OJT,Haley KM

更新日期：2020-01-01 00:00:00

abstract：:ADP induces platelet aggregation in human whole blood and platelet-rich plasma (PRP). ATP induces aggregation in whole blood only; this involves leukocytes and is mediated by ADP. Here we studied ATP- and ADP-induced aggregation in patients with raised leukocyte counts (mean 46.2x10(3) leukocytes/microl). Platelet agg...

journal_title：Platelets

authors： Glenn JR,White AE,Johnson A,Fox SC,Behan MW,Dolan G,Heptinstall S

更新日期：2005-05-01 00:00:00

abstract：:Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...

journal_title：Platelets

authors： Yakushkin VV,Zyuryaev IT,Khaspekova SG,Sirotkina OV,Ruda MY,Mazurov AV

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:Thrombocytopenia is common in patients with lung diseases. Lung injury is associated with deranged platelet homeostasis. The potential mechanisms underlying this association were investigated in this study. The number and morphology of circulating megakaryocytes (MK) were investigated in vivo during cardiopulmonary by...

journal_title：Platelets

authors： Xiao da W,Yang M,Yang J,Hon KL,Fok FT

更新日期：2006-08-01 00:00:00

abstract：:Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), perf...

journal_title：Platelets

authors： Tanous O,Steinberg Shemer O,Yacobovich J,Zoldan M,Horovitz Y,Yaniv I,Rabizadeh E,Tamary H,Nakav S,Lahav J

更新日期：2017-11-01 00:00:00

abstract：:Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...

journal_title：Platelets

authors： Rubak P,Nissen PH,Kristensen SD,Hvas AM

更新日期：2016-01-01 00:00:00

abstract：:In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...

journal_title：Platelets

authors： Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

更新日期：2016-06-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease. Since the prevalence of NAFLD in overweight/obese people is rather high, there is a general concern about the possibility that NAFLD may have an association with cardiovascular risk factors and atherosclerosis. Mean platelet volume (MPV) i...

journal_title：Platelets

authors： Shin WY,Jung DH,Shim JY,Lee HR

更新日期：2011-01-01 00:00:00

abstract：:Stripping of cytoplasm from circulating megakaryocytes (MKs) in the pulmonary capillary bed implicates the lungs as an important site for platelet production in normal physiology. The placenta has been proposed as an alternative location for intrauterine platelet production as fetal lungs are essentially non-functioni...

journal_title：Platelets

authors： Woods MJ,Landon CR,Greaves M,Trowbridge EA

更新日期：1992-01-01 00:00:00

abstract：:Patients with peripheral artery disease (PAD) following peripheral percutaneous transluminal angioplasty (PTA) with stent implantation are prone to stent thrombosis despite treatment with aspirin and clopidogrel. Impaired clopidogrel responsiveness is associated with increased risk of ischemic events in patients follo...

journal_title：Platelets

authors： Mazur P,Frołow M,Niżankowski R,Sadowski J,Undas A

更新日期：2013-01-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...

journal_title：Platelets

authors： Lim CC,Patel DK,Bakhtiari A,Subrayan V

更新日期：2013-01-01 00:00:00

abstract：:Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

journal_title：Platelets

authors： Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

更新日期：2012-01-01 00:00:00

abstract：:The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise...

journal_title：Platelets

authors： Salim JP,Glembotsky AC,Lev PR,Marin Oyarzún CP,Goette NP,Molinas FC,Marta RF,Heller PG

更新日期：2017-09-01 00:00:00

abstract：:The action of sodium nitroprusside, an activator of guanylate cyclase, on rabbit platelets stimulated with PAF-acether, was studied singly or in combination with verapamil. Not only did sodium nitroprusside in the range 10(-6) to 10(-4) M inhibit PAF-acether induced aggregation, but it also brought about desaggregatio...

journal_title：Platelets

authors： Khan SN,Smith AD,Neal CR,Pittilo RM

更新日期：1993-01-01 00:00:00

abstract：:Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. Aronia melanocarpa fruits (Rosaceae) are one of the richest plant sources of phenolic substances shown to have anti-inflammatory, antitumor, antioxidative and antiplate...

journal_title：Platelets

authors： Olas B,Kedzierska M,Wachowicz B,Stochmal A,Oleszek W

更新日期：2010-01-01 00:00:00