Abstract:
:Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surface and platelet aggregating activity. GP IIb-IIIa number, measured as maximal binding of complex-specific monoclonal antibody, varied by approximately two fold in both healthy volunteers (n = 35) and patients with acute coronary syndrome (ACS) (n = 65). In healthy volunteers positive associations were observed between GP IIb-IIIa number and the level of ADP-induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of aspirin or non-saturating concentrations of GP IIb-IIIa blockers. In the same group of volunteers almost no differences in aggregating activity were detected between donors carrying the GP IIIa Pro33 allele (n = 15) and those with the GP IIIa Leu33Leu33 genotype (n = 20). No significant relationships were revealed between platelet aggregability and variations of plasma fibrinogen concentration. Positive correlation of the level of ADP-induced aggregation and GP IIb-IIIa content was detected in patients with ACS within the first hour upon admission to the hospital when they had already received aspirin, but not clopidogrel. However, there were no correlations between these parameters at days 3-5 and days 8-12 (before discharge). At these time points patients were treated not only with aspirin but were saturated with clopidogrel as well. In ACS patients we also evaluated the expression of another platelet adhesive receptor, GP Ib, and found a significant positive correlation between GP IIb-IIIa and GP Ib content. A strong association was also revealed between the number of both receptors and mean platelet volume. The latter observation indicated that individual variations of the number of glycoprotein molecules are mainly affected by platelet size but not the density of their expression on the platelet membrane. Possible usefulness of measuring GP IIb-IIIa content as a marker of increased platelet reactivity is discussed.
journal_name
Plateletsjournal_title
Plateletsauthors
Yakushkin VV,Zyuryaev IT,Khaspekova SG,Sirotkina OV,Ruda MY,Mazurov AVdoi
10.3109/09537104.2010.547959subject
Has Abstractpub_date
2011-01-01 00:00:00pages
243-51issue
4eissn
0953-7104issn
1369-1635journal_volume
22pub_type
杂志文章,评审相关文献
PLATELETS文献大全abstract::Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1445839
更新日期:2018-07-01 00:00:00
abstract::In the presence of large bone defects, delayed bone union, or nonunion and fractures, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates (APCs). Due to the high content of platelets and platelet-derived bioactive...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2017.1384537
更新日期:2018-06-01 00:00:00
abstract::Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1430358
更新日期:2018-11-01 00:00:00
abstract::Platelets from patients with type 2 diabetes show abnormalities in intracellular Ca(2+) homeostasis that are involved in platelet hyperaggregability and the development of thrombotic complications. Different Ca(2+) transport mechanisms have been reported to be altered in platelets from patients with type 2 diabetes, i...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.528813
更新日期:2011-01-01 00:00:00
abstract::Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the re...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1445835
更新日期:2019-01-01 00:00:00
abstract::Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1031650
更新日期:2015-01-01 00:00:00
abstract::Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.525722
更新日期:2011-01-01 00:00:00
abstract::The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.512403
更新日期:2010-01-01 00:00:00
abstract::The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701708506
更新日期:2008-02-01 00:00:00
abstract::The isolation of mitochondria is gaining importance in experimental and clinical laboratory settings. The mitochondrion is known as the powerhouse of the cell as it produces the energy to power most cellular functions but is also involved in many cellular processes. Of interest, mitochondria and mitochondrial componen...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1609666
更新日期:2020-01-01 00:00:00
abstract::The aim of this survey was to describe drug-induced immune thrombocytopenia (ITP) reported in the French PharmacoVigilance database (FPVD) and to discuss the drugs involved. The request to the FPVD used the seven most accurate diagnosis codes to identify ITP. The study was restricted to cases reported from 2007 to 201...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.633179
更新日期:2012-01-01 00:00:00
abstract::The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109976103
更新日期:1999-07-01 00:00:00
abstract::Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP), signaling via phospholipase (PLC)β isoforms. The platelet ILRs glycoprote...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1859103
更新日期:2020-12-26 00:00:00
abstract::Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been...
journal_title:Platelets
pub_type: 杂志文章,meta分析,评审
doi:10.1080/09537104.2018.1442567
更新日期:2018-05-01 00:00:00
abstract::In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1235686
更新日期:2017-06-01 00:00:00
abstract::To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were ...
journal_title:Platelets
pub_type: 杂志文章,多中心研究
doi:10.3109/09537104.2012.731111
更新日期:2013-01-01 00:00:00
abstract::Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...
journal_title:Platelets
pub_type: 杂志文章,meta分析
doi:10.1080/09537104.2018.1543864
更新日期:2019-01-01 00:00:00
abstract::FVIII is an important cofactor in the tenase coagulation factor complex, lack of FVIII causes severe bleeding, whereas high FVIII levels seem to be associated with venous and arterial thromboembolism. Resting platelets do not bind FVIII, but activated platelets bind unactivated FVIII if vWF is not present. We investig...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600747035
更新日期:2006-11-01 00:00:00
abstract::In recent years the involvement of platelets dysfunction in atherogenesis and in the clinical complications from atherosclerosis has become more recognised. Systemic platelet-related thrombogenic factors have been shown to be involved in the initiation and progression of atherogenesis and plaque growth. Over the last ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/0953770021000007221
更新日期:2002-08-01 00:00:00
abstract::SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109109005512
更新日期:1991-01-01 00:00:00
abstract::The generation of superoxide anion radicals (O2*-) and the other reactive oxygen species (ROS) was estimated by means of cytochrome c reduction and chemiluminescence, as well in resting blood platelets and in platelets stimulated by thrombin in the presence or absence of some inhibitors of pathways involved in platele...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09533710022149395
更新日期:2002-05-01 00:00:00
abstract::Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100903096676
更新日期:2009-09-01 00:00:00
abstract::Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1573314
更新日期:2020-01-01 00:00:00
abstract::Selected aspirin treated patients may exhibit high platelet reactivity to agonists other than arachidonic acid. This study aimed to determine whether the VerifyNow identifies generalized high platelet reactivity supported by correlations with other established methods that stimulate platelets with various agonists. St...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537100701206824
更新日期:2007-09-01 00:00:00
abstract::Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2017.1319047
更新日期:2017-07-01 00:00:00
abstract::Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Diso...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802010547
更新日期:2008-08-01 00:00:00
abstract::Recent studies suggest that anti-platelet agents are not equally effective in all individuals. We have developed a new method to evaluate the effect of anti-platelet drugs using the cone and plate(let) analyzer (CPA) test. The method is based on the ability of activators to reduce platelet adhesion under flow conditio...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100400028800
更新日期:2005-08-01 00:00:00
abstract::Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor could impact the dis...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1356453
更新日期:2018-11-01 00:00:00
abstract::In humans and other mammals, Tityus discrepans (Td) scorpion envenomation produces a variety of systemic effects including respiratory distress, a generalized inflammatory reaction, modulation of blood pressure, fibrin formation, and platelet activation. For many of these effects, the venom components and underlying m...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.544343
更新日期:2011-01-01 00:00:00
abstract::In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1095873
更新日期:2016-06-01 00:00:00