Abstract:
:The action of sodium nitroprusside, an activator of guanylate cyclase, on rabbit platelets stimulated with PAF-acether, was studied singly or in combination with verapamil. Not only did sodium nitroprusside in the range 10(-6) to 10(-4) M inhibit PAF-acether induced aggregation, but it also brought about desaggregation of previously aggregated platelets, as also did verapamil. The results were compared with those obtained with PGE(1), when used alone and in combination with verapamil. Morphological studies were carried out on control and aggregated platelets, and on platelets treated with verapamil either to inhibit aggregation or to bring about desaggregation. The platelets that had been desaggregated by verapamil were discoid in shape, had very few pseudopodia and exhibited a near normal internal morphology, except that the open canalicular system was swollen and contained an electron dense material resembling the contents of the alpha granules. The morphology of platelets desaggregated by PGE(1) was similar to that of platelets desaggregated by verapamil, including a swollen canalicular system containing electron dense material.
journal_name
Plateletsjournal_title
Plateletsauthors
Khan SN,Smith AD,Neal CR,Pittilo RMdoi
10.3109/09537109309013211subject
Has Abstractpub_date
1993-01-01 00:00:00pages
150-5issue
3eissn
0953-7104issn
1369-1635journal_volume
4pub_type
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