Catastrophic antiphospholipid syndrome refractory to high-dose intravenous immunoglobulin responsive to therapeutic plasma exchange.

abstract：:Interaction of von Willebrand factor (VWF) with circulating platelets promotes hemostasis when a blood vessel is injured. The A1 domain of VWF is responsible for the initial interaction with platelets and is well conserved among species. Knowledge of the cDNA and genomic DNA sequences for human VWF allowed us to predi...

journal_title：Platelets

authors： Chitta MS,Duhé RJ,Kermode JC

更新日期：2007-05-01 00:00:00

abstract：:Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP), signaling via phospholipase (PLC)β isoforms. The platelet ILRs glycoprote...

journal_title：Platelets

authors： Fernández DI,Kuijpers MJE,Heemskerk JWM

更新日期：2020-12-26 00:00:00

abstract：:Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes. The effect of P2Y12 inhibitors on pro-coagulatory, phosphatidylserine (PS)-expressing EV has been investigated previously, but onl...

journal_title：Platelets

authors： Haller PM,Stojkovic S,Piackova E,Andric T,Wisgrill L,Spittler A,Wojta J,Huber K,Jäger B

更新日期：2020-05-18 00:00:00

abstract：:This phase III, randomized, placebo-controlled study conducted in three stages (6-week, randomized, placebo-controlled stage 1; 24-week, open-label stage 2; and continuous extension stage 3) assessed the long-term efficacy and safety of eltrombopag use in Chinese patients with chronic immune thrombocytopenia (ITP). Th...

journal_title：Platelets

authors： Liu X,Hou M,Li J,Jin J,Huang M,Yu Z,Xu X,Zhang X,Yang R

更新日期：2020-11-29 00:00:00

abstract：:The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...

journal_title：Platelets

authors： Breimo ES,Østerud B

更新日期：2003-11-01 00:00:00

abstract：:We previously reported the effects of diet, sulphonylureas or insulin on thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in non-insulin-dependent diabetes mellitus (NIDDM) patients. To clarify the mechanism of glyburide and insulin on platelet function, here we studied th...

journal_title：Platelets

authors： Wada H,Ishizuka T,Itaya S,Yamada K,Kajita K,Kimura M,Miura A,Shibata T,Kanoh Y,Ishizawa M,Yasuda K

更新日期：1999-01-01 00:00:00

abstract：:The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...

journal_title：Platelets

authors： Moseley GW

更新日期：2005-02-01 00:00:00

abstract：:Flow cytometric analysis of human platelets from healthy volunteers by high-resolution immunophenotyping accomplished with enzymatic amplification staining revealed the expression of CD34. Assessment of the platelets with five different monoclonal antibodies to the three different classes of CD34 epitopes suggested th...

journal_title：Platelets

authors： Lewandowska K,Kaplan D,Husel W

更新日期：2003-03-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or '...

journal_title：Platelets

authors： Gachet C,Hechler B,Léon C,Vial C,Ohlmann P,Cazenave JP

更新日期：1996-01-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...

journal_title：Platelets

authors： White JG,Kumar A,Hogan MJ

更新日期：2006-12-01 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...

journal_title：Platelets

authors： Mathai J,Resmi KR,Sulochana PV,Sathyabhama S,Baby Saritha G,Krishnan LK

更新日期：2006-09-01 00:00:00

abstract：:Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender,...

journal_title：Platelets

authors： Berlin G,Hammar M,Tapper L,Tynngård N

更新日期：2019-01-01 00:00:00

abstract：:Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is a mainstay of the prevention of stent thrombosis following percutaneous coronary intervention (PCI). In the 2015 European guidelines for the management of acute coronary syndrome (ACS), prasugrel (PRA) and ticagrelor (TICA) combined with aspirin ar...

journal_title：Platelets

authors： Selhorst G,Schmidtler F,Ott A,Hitzke E,Tomelden J,Antoni D,Hoffmann E,Rieber J

更新日期：2019-01-01 00:00:00

abstract：:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

journal_title：Platelets

authors： Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

更新日期：2004-02-01 00:00:00

abstract：:We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with thrombocytopenia. Following inefficient treatment of four platelet transfusions, immunoglobulins, and corticosteroids, we initiated treatment with a thrombopoietin (TPO)...

journal_title：Platelets

authors： Espitia O,Ternisien C,Agard C,Boisseau P,Denis CV,Fouassier M

更新日期：2017-07-01 00:00:00

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...

journal_title：Platelets

authors： Gokalp D,Tuzcu A,Bahceci M,Ayyildiz O,Erdemoglu M,Alpagat G

更新日期：2011-01-01 00:00:00

abstract：:Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...

journal_title：Platelets

authors： Zhang C,Neelamegham S

更新日期：2017-07-01 00:00:00

abstract：:In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...

journal_title：Platelets

authors： Meyer M,Thieme A,Jablonka B,Just M,Ströhl C,Schellenberg I,Kirchmaier CM

更新日期：1996-01-01 00:00:00

abstract：:We have investigated interactions between human blood platelets and the vitronectin-containing fluid-phase terminal complement complex, the SC5b-9, which is a non-cytolytic variant of the membrane attack complex C%9(m). SC5b-9 affinity for the platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) complex was demonstrat...

journal_title：Platelets

authors： Røger M,Høgåsen K,Holme PA,Halstensen TS,Mollnes TE,Hovig T

更新日期：1995-01-01 00:00:00

abstract：:Platelet-surface contact is the first step in thrombus formation. Platelet spreading makes this initial contact irreversible. On the other hand plasma lipids and fibrinogen have been described to activate platelets or promote adhesion. We therefore investigated whether platelet spreading under stagnation-point flow co...

journal_title：Platelets

authors： Reininger AJ,Reininger CB,Agneskirchner J,Scherb H,Spannagl M,Wurzinger LJ

更新日期：1998-01-01 00:00:00

abstract：:The aim of the present retrospective observational study was to evaluate the time of functional recovery following a specific combined therapeutic approach characterized by an active exercise therapy carried out immediately after Platelet-rich plasma (PRP) injections for the treatment of the muscular lesion of the dis...

journal_title：Platelets

authors： Borrione P,Fossati C,Pereira MT,Giannini S,Davico M,Minganti C,Pigozzi F

更新日期：2018-09-01 00:00:00

abstract：:Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

journal_title：Platelets

authors： Chen Y,Yang Y,Cheng J,Lu J,Hu W

更新日期：2020-01-01 00:00:00

abstract：:Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. T...

journal_title：Platelets

authors： Au AE,Josefsson EC

更新日期：2017-06-01 00:00:00

abstract：:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were...

journal_title：Platelets

authors： Zhao P,Hou M,Liu Y,Liu HX,Huang RB,Yao HX,Niu T,Peng J,Jiang M,Han YQ,Hu JD,Zhou H,Zhou ZP,Qiu L,Zhang LS,Wang X,Wang HQ,Feng R,Yang LH,Ma LM,Wang SQ,Kong PY,Wang WS,Sun HP,Sun J,Zhou HB,Zhu TN,Wang

更新日期：2020-07-02 00:00:00

abstract：:Pre-analytical variables interact with standard coagulation parameters. How these variables affect the platelet function analysis is not completely known. How collection site and puncture method affect multiple electrode aggregometry (MEA) and platelet function analyzer (PFA-100®) was compared regarding contact activa...

journal_title：Platelets

authors： Lancé MD,Henskens YM,Nelemans P,Theunissen MH,Oerle RV,Spronk HM,Marcus MA

更新日期：2013-01-01 00:00:00

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00