Influence of a single dose of calcium channel blockers on platelet function.

Abstract:

:Calcium channel blockers are known to inhibit platelet aggregation in vitro and ex vivo. We studied the influence of a single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg) on ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and platelet sensitivity to PGI(2) in 24 patients with coronary artery disease. Ninety minutes after drug intake most platelet function parameters were clearly decreased. Only collagen-stimulated platelet aggregation showed no significant drug effect. Malondialdehyde formation was more affected than ADP-induced platelet aggregation. Platelet sensitivity to PGI(2) was enhanced after nifedipine. These results suggest an alteration of the prostaglandin system as one of the underlying mechanisms. Diltiazem seems to be the most effective drug with a potent influence on platelet function ex vivo.

journal_name

Platelets

journal_title

Platelets

authors

Weiss K,Fitscha P,Virgolini I,O'grady J,Sinzinger H

doi

10.3109/09537109109005501

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

41-3

issue

1

eissn

0953-7104

issn

1369-1635

journal_volume

2

pub_type

杂志文章
  • Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway.

    abstract::In humans and other mammals, Tityus discrepans (Td) scorpion envenomation produces a variety of systemic effects including respiratory distress, a generalized inflammatory reaction, modulation of blood pressure, fibrin formation, and platelet activation. For many of these effects, the venom components and underlying m...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2010.544343

    authors: Brazón J,Hughes CE,Mori J,Sevcik C,D'suze G,Watson SP

    更新日期:2011-01-01 00:00:00

  • The expression of IFN-gamma, IL-4, Foxp3 and perforin genes are not correlated with DNA methylation status in patients with immune thrombocytopenic purpura.

    abstract::We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. Th...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537100903420277

    authors: Zhao H,Du W,Wang D,Gu D,Xue F,Ge J,Sui T,Yang R

    更新日期:2010-01-01 00:00:00

  • Vigorous exercise as a triggering mechanism for late stent thrombosis: A description of three cases.

    abstract::Although (very) late coronary stent thrombosis is a rare complication after percutaneous coronary interventions (PCI), its consequences are devastating with a high morbidity and mortality. Previous studies have identified several clinical, procedural and angiographic characteristics that are associated with stent thro...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537100903388367

    authors: Zwart B,Van Kerkvoorde TC,van Werkum JW,Breet NJ,Ten Berg JM,Van 't Hof AW

    更新日期:2010-01-01 00:00:00

  • The association between non-alcoholic hepatic steatosis and mean platelet volume in an obese Korean population.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease. Since the prevalence of NAFLD in overweight/obese people is rather high, there is a general concern about the possibility that NAFLD may have an association with cardiovascular risk factors and atherosclerosis. Mean platelet volume (MPV) i...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2010.540049

    authors: Shin WY,Jung DH,Shim JY,Lee HR

    更新日期:2011-01-01 00:00:00

  • Thrombopoietin-receptor agonists in haematological disorders: the Danish experience.

    abstract::The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 200...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.634931

    authors: Gudbrandsdottir S,Frederiksen H,Hasselbalch H

    更新日期:2012-01-01 00:00:00

  • Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia.

    abstract::In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1235686

    authors: Unterberger U,Eichelberger B,Ulz A,Panzer S

    更新日期:2017-06-01 00:00:00

  • Thrombocytopenia and GBA gene mutation in a patient with adult type 1 Gaucher disease.

    abstract::A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...

    journal_title:Platelets

    pub_type: 信件

    doi:10.1080/09537104.2017.1306044

    authors: Wan L,Wu H,Xie F,Nie Y

    更新日期:2017-12-01 00:00:00

  • Effects of polyphenol-rich extract from berries of Aronia melanocarpa on the markers of oxidative stress and blood platelet activation.

    abstract::Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. Aronia melanocarpa fruits (Rosaceae) are one of the richest plant sources of phenolic substances shown to have anti-inflammatory, antitumor, antioxidative and antiplate...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537101003612821

    authors: Olas B,Kedzierska M,Wachowicz B,Stochmal A,Oleszek W

    更新日期:2010-01-01 00:00:00

  • Interactive protein network of FXIII-A1 in lipid rafts of activated and non-activated platelets.

    abstract::Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2016.1153621

    authors: Rabani V,Montange D,Davani S

    更新日期:2016-09-01 00:00:00

  • Application of microfluidic devices in studies of thrombosis and hemostasis.

    abstract::Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2017.1319047

    authors: Zhang C,Neelamegham S

    更新日期:2017-07-01 00:00:00

  • Spreading of platelets: a morphological marker for platelet reactivity in peripheral arterial occlusive disease.

    abstract::Platelet-surface contact is the first step in thrombus formation. Platelet spreading makes this initial contact irreversible. On the other hand plasma lipids and fibrinogen have been described to activate platelets or promote adhesion. We therefore investigated whether platelet spreading under stagnation-point flow co...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109876771

    authors: Reininger AJ,Reininger CB,Agneskirchner J,Scherb H,Spannagl M,Wurzinger LJ

    更新日期:1998-01-01 00:00:00

  • The role of platelet activation in determining response to therapy in patients with primary nephrotic syndrome.

    abstract::To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were ...

    journal_title:Platelets

    pub_type: 杂志文章,多中心研究

    doi:10.3109/09537104.2012.731111

    authors: Kocyigit I,Yilmaz MI,Simşek Y,Unal A,Sipahioglu MH,Eroglu E,Dede F,Tokgoz B,Oymak O,Utas C

    更新日期:2013-01-01 00:00:00

  • Regulation of platelet membrane protein shedding in health and disease.

    abstract::Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. T...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2016.1203401

    authors: Au AE,Josefsson EC

    更新日期:2017-06-01 00:00:00

  • Comparison of the release of microRNAs and extracellular vesicles from platelets in response to different agonists.

    abstract::On activation platelets release microRNAs and extracellular vesicles (EV) into circulation. The release of EV from platelets has been shown to be dependent on the agonist; in this study, we investigated whether the microRNA profile or EV released from platelets was also agonist specific. Washed platelets from healthy ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2017.1332366

    authors: Ambrose AR,Alsahli MA,Kurmani SA,Goodall AH

    更新日期:2018-07-01 00:00:00

  • Interactions of platelets with Synthocytes, a novel platelet substitute.

    abstract::A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/0953371027000

    authors: Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

    更新日期:2002-06-01 00:00:00

  • Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets.

    abstract::Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100500163457

    authors: Gende OA

    更新日期:2005-11-01 00:00:00

  • Prasugrel or double-dose clopidogrel to overcome clopidogrel low-response--the TAILOR (Thrombocytes And IndividuaLization of ORal antiplatelet therapy in percutaneous coronary intervention) randomized trial.

    abstract::High on-treatment platelet reactivity (HTPR) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). The antiplatelet effect and safety of prasugrel was compared to that of double-dose clopidogrel in patients with stable coronary artery disease or acute coronary syndrome (ACS...

    journal_title:Platelets

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/09537104.2013.845874

    authors: Dridi NP,Johansson PI,Clemmensen P,Stissing T,Radu MD,Qayyum A,Pedersen F,Helqvist S,Saunamäki K,Kelbæk H,Jørgensen E,Engstrøm T,Holmvang L

    更新日期:2014-01-01 00:00:00

  • Impact of ticagrelor on P2Y1 and P2Y12 localization and on cholesterol levels in platelet plasma membrane.

    abstract::Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor could impact the dis...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2017.1356453

    authors: Rabani V,Montange D,Meneveau N,Davani S

    更新日期:2018-11-01 00:00:00

  • ATP does not affect fibrinogen binding to platelet GPIIbIIIa in systems free of signal transduction.

    abstract::Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. However, any direct ef...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109975889

    authors: Liu Q,Sloan S,Frojmovic MM

    更新日期:1999-01-01 00:00:00

  • Measuring soluble platelet glycoprotein VI in human plasma by ELISA.

    abstract::Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100802710286

    authors: Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

    更新日期:2009-05-01 00:00:00

  • Aspirin, platelet inhibition and cancer prevention.

    abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2018.1492105

    authors: Patrignani P,Patrono C

    更新日期:2018-12-01 00:00:00

  • Novel mutations in GP IIb gene in Glanzmann's thrombasthenia from India.

    abstract::The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100802434861

    authors: Vijapurkar M,Ghosh K,Shetty S

    更新日期:2009-02-01 00:00:00

  • Efficacy and safety of different ticagrelor regimens versus clopidogrel in patients with coronary artery disease: a retrospective multicenter study (SUPERIOR).

    abstract::Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2020.1732328

    authors: Shi J,He M,Wang W,Liu G,Zhang H,Sun D,Li J,Mu H,Xu M,Zhao C,Wang J,Zhang C,Cang H,Zhao S,Zhang Z,Li Y

    更新日期:2021-01-02 00:00:00

  • The value of proteomics for the diagnosis of a platelet-related bleeding disorder.

    abstract::Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Diso...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100802010547

    authors: Maurer-Spurej E,Kahr WH,Carter CJ,Pittendreigh C,Cameron M,Cyr TD

    更新日期:2008-08-01 00:00:00

  • Studies of biological functions in blood cells from individuals with large platelets.

    abstract::The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/02697450310001632597

    authors: Breimo ES,Østerud B

    更新日期:2003-11-01 00:00:00

  • The placenta: a site of platelet production?

    abstract::Stripping of cytoplasm from circulating megakaryocytes (MKs) in the pulmonary capillary bed implicates the lungs as an important site for platelet production in normal physiology. The placenta has been proposed as an alternative location for intrauterine platelet production as fetal lungs are essentially non-functioni...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109209013185

    authors: Woods MJ,Landon CR,Greaves M,Trowbridge EA

    更新日期:1992-01-01 00:00:00

  • Update on functional and genetic laboratory assays for the detection of platelet microvesicles.

    abstract::Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2016.1265925

    authors: Laroche M,Dunois C,Vissac AM,Amiral J

    更新日期:2017-05-01 00:00:00

  • Response of blood platelets to resveratrol.

    abstract::The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109976103

    authors: Zbikowska HM,Olas B,Wachowicz B,Krajewski T

    更新日期:1999-07-01 00:00:00

  • Prostaglandin Regulation of Cyclic AMP Metabolism in Human Platelets.

    abstract::Prostaglandins stimulate cyclic AMP synthesis in platelets, leading to inhibition of platelet aggregation. Prostaglandin receptors have been identified but knowledge of their pharmacology is limited by the lack of antagonists. Kinetic measurements of prostaglandinregulated cyclic AMP formation provide useful informati...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109009009190

    authors: Ashby B

    更新日期:1990-01-01 00:00:00

  • The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea.

    abstract::Previous studies have reported increased platelet activation and aggregation in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) treatment has been shown to decrease platelet activation. We aimed to study the effects of nasal CPAP therapy has on MPV values in patients with severe...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.578182

    authors: Varol E,Ozturk O,Yucel H,Gonca T,Has M,Dogan A,Akkaya A

    更新日期:2011-01-01 00:00:00