An adaptable analysis workflow for characterization of platelet spreading and morphology.

abstract：:On activation platelets release microRNAs and extracellular vesicles (EV) into circulation. The release of EV from platelets has been shown to be dependent on the agonist; in this study, we investigated whether the microRNA profile or EV released from platelets was also agonist specific. Washed platelets from healthy ...

journal_title：Platelets

authors： Ambrose AR,Alsahli MA,Kurmani SA,Goodall AH

更新日期：2018-07-01 00:00:00

abstract：:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

journal_title：Platelets

authors： Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

更新日期：2004-02-01 00:00:00

abstract：:A pathogen-free and standardized xeno-free supplement of growth media is required for the ex vivo propagation of human cells used as advanced therapeutic medicinal products and for clinical translation in regenerative medicine and cell therapies. Human platelet lysate (HPL) made from therapeutic-grade platelet concent...

journal_title：Platelets

authors： Barro L,Burnouf PA,Chou ML,Nebie O,Wu YW,Chen MS,Radosevic M,Knutson F,Burnouf T

更新日期：2020-11-29 00:00:00

abstract：:SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...

journal_title：Platelets

authors： Margalit A,Livne AA

更新日期：1991-01-01 00:00:00

abstract：:A major challenge in the use of artificial materials for implant devices, artificial organs, and extra-corporeal circulation systems, is the adhesion of platelets and the subsequent formation of platelet aggregates on the non-biological surface. The mechanism of platelet attachment to artificial surfaces is not comple...

journal_title：Platelets

authors： Røger M,Høgåsen K,Mollnes TE,Hovig T

更新日期：1994-01-01 00:00:00

abstract：:A controversial discussion as to whether human platelets are capable of regulated protein synthesis has been ongoing for over half a century. A previous study has suggested that human platelets synthesize large amounts of interleukin 1beta (IL-1beta) in response to external cues and in a physiologically significant ma...

journal_title：Platelets

authors： Pillitteri D,Bassus S,Boller K,Mahnel R,Scholz T,Westrup D,Wegert W,Kirchmaier CM

更新日期：2007-03-01 00:00:00

abstract：:Thrombocytopenia is common in the neonatal intensive care unit. Transfusion of platelets is often required. The purpose of our study was to determine changes in thrombopoietin (Tpo) following transfusion of platelets in preterm neonates. Preterm neonates undergoing platelet transfusion were randomized to receive a tra...

journal_title：Platelets

authors： Kline A,Mackley A,Taylor SM,McKenzie SE,Paul DA

更新日期：2008-09-01 00:00:00

abstract：:Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...

journal_title：Platelets

authors： Vila PM,Zafar MU,Badimon JJ

更新日期：2009-12-01 00:00:00

abstract：:Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...

journal_title：Platelets

authors： Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

更新日期：2019-01-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:In humans and other mammals, Tityus discrepans (Td) scorpion envenomation produces a variety of systemic effects including respiratory distress, a generalized inflammatory reaction, modulation of blood pressure, fibrin formation, and platelet activation. For many of these effects, the venom components and underlying m...

journal_title：Platelets

authors： Brazón J,Hughes CE,Mori J,Sevcik C,D'suze G,Watson SP

更新日期：2011-01-01 00:00:00

abstract：:Thrombosis and bleeding are devastating adverse events in patients supported with blood-contacting medical devices (BCMDs). In this study, we delineated that high non-physiological shear stress (NPSS) caused platelet dysfunction that may contribute to both thrombosis and bleeding. Human blood was subjected to NPSS wit...

journal_title：Platelets

authors： Chen Z,Mondal NK,Zheng S,Koenig SC,Slaughter MS,Griffith BP,Wu ZJ

更新日期：2019-01-01 00:00:00

abstract：:Measurement of platelet aggregation in platelet-rich plasma (PRP) is a fundamental tool in platelet studies, despite the fact that the technique required for this is time-consuming, may need large volumes of blood, and require particular skill and special equipment. The use of a microplate reader seems useful to perfo...

journal_title：Platelets

authors： Krause S,Scholz T,Temmler U,Lösche W

更新日期：2001-11-01 00:00:00

abstract：:Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive ...

journal_title：Platelets

authors： Chen S,Hu M,Shen M,Xu Y,Wang C,Wang X,Li F,Zeng D,Chen F,Zhao G,Chen M,Wang F,Cheng T,Su Y,Zhao J,Wang S,Wang J

更新日期：2018-11-01 00:00:00

abstract：:Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm3) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adul...

journal_title：Platelets

authors： Dhanoa A,Rajasekaram G,Hassan SS,Ramadas A,Azreen Adnan NA,Lau CF,Chan TS,Ngim CF

更新日期：2017-11-01 00:00:00

abstract：:Whether the simultaneous administration of ciprofloxacin or tazobactam/piperacillin increases the risk of thrombocytosis is unknown. Broncho-pulmonary infection in a 50-year-old male with acute, hypertensive, intracerebral bleeding, necessitated therapy with cefpirome (2 g/day, 6 days), ciprofloxacin (800 mg/d, 11 day...

journal_title：Platelets

authors： Finsterer J,Kotzailias N

更新日期：2003-08-01 00:00:00

abstract：:In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...

journal_title：Platelets

authors： Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

更新日期：2016-06-01 00:00:00

abstract：:Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...

journal_title：Platelets

authors： Lim CC,Patel DK,Bakhtiari A,Subrayan V

更新日期：2013-01-01 00:00:00

abstract：:The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...

journal_title：Platelets

authors： Gabbasov Z,Parfyonova Y,Popov E,Gavrilov I,Anuchin V,Dubov P,Djakonova Y

更新日期：1998-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...

journal_title：Platelets

authors： Dehghani F,Sotoude N,Bordbar H,Panjeshahin MR,Karbalay-Doust S

更新日期：2019-01-01 00:00:00

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00

abstract：:Platelet aggregation is usually measured by a spectroscopic method using an aggregometer. However, when the process of platelet aggregation is followed by the changes in light transmission of platelet-rich plasma (PRP), factors such as platelet deformation or changes in plasma permeability must be taken into considera...

journal_title：Platelets

authors： Suehiro A,Higashi T,Kakishita E

更新日期：1992-01-01 00:00:00

abstract：:Activated platelets serve as a catalyst for thrombin generation and a source of vasoactive and mitogenic factors affecting vascular remodeling. Oral menopausal hormone treatments (MHT) may carry greater thrombotic risk than transdermal products. This study compared effects of oral and transdermal MHT on platelet chara...

journal_title：Platelets

authors： Miller VM,Lahr BD,Bailey KR,Heit JA,Harman SM,Jayachandran M

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It i...

journal_title：Platelets

authors： Rifaioglu EN,Sen BB,Ekiz Ö,Dogramaci AC

更新日期：2014-01-01 00:00:00

abstract：:Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The rela...

journal_title：Platelets

authors： Bakken AM,Hervig T,Thorsen T,Holmsen H

更新日期：1995-01-01 00:00:00

abstract：:The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...

journal_title：Platelets

authors： Zbikowska HM,Olas B,Wachowicz B,Krajewski T

更新日期：1999-07-01 00:00:00

abstract：:Platelet aggregation in response to ADP, adrenaline, collagen, arachidonic acid and ristocetin was measured in a large population of healthy Saudi males (n = 393) and females (n = 221) whose age ranged from 11-60 years. The number of observations ranged from 130 for one of the doses of ristocetin (1.0 g/l) to 554 for ...

journal_title：Platelets

authors： Gader AM,Bahakim HM,Malaika SS

更新日期：1990-01-01 00:00:00

abstract：:SIRT1, a class III histone deacetylase, is critically involved in cellular response to stress and modulates cardiovascular risk factors. However, its role in thrombus formation is largely unknown. Thus, this study investigated the effect of SIRT1 on pulmonary thrombus formation, and then identified its role in the mod...

journal_title：Platelets

authors： Kim YH,Bae JU,Kim IS,Chang CL,Oh SO,Kim CD

更新日期：2016-12-01 00:00:00

abstract：:Ethylenediaminetetraacetic acid (EDTA) causes structural, biochemical and functional damage to blood platelets. The alterations induced are considered irreversible. However, the degree of irreversibility, and whether all functions are similarly compromised by EDTA have not been fully evaluated. The present study has e...

journal_title：Platelets

authors： White JG,Krumwiede MD,Escolar G

更新日期：1999-01-01 00:00:00

abstract：:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...

journal_title：Platelets

authors： Coban E,Kucuktag S,Basyigit S

更新日期：2007-12-01 00:00:00