Effect of the psoralen-based photochemical pathogen inactivation on mitochondrial DNA in platelets.

abstract：:It has been suggested that thromboelastography TEG) can help in limiting or directing the appropriate use of blood products during surgery. However, the contribution of platelets to the TEG profile has not been studied in detail. Blood was taken from eight healthy subjects and eight patients with peripheral arterial d...

journal_title：Platelets

authors： Bowbrick VA,Mikhailidis DP,Stansby G

更新日期：2003-06-01 00:00:00

abstract：:Ethylenediaminetetraacetic acid (EDTA) causes structural, biochemical and functional damage to blood platelets. The alterations induced are considered irreversible. However, the degree of irreversibility, and whether all functions are similarly compromised by EDTA have not been fully evaluated. The present study has e...

journal_title：Platelets

authors： White JG,Krumwiede MD,Escolar G

更新日期：1999-01-01 00:00:00

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00

abstract：:The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 200...

journal_title：Platelets

authors： Gudbrandsdottir S,Frederiksen H,Hasselbalch H

更新日期：2012-01-01 00:00:00

abstract：:The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...

journal_title：Platelets

authors： Gabbasov Z,Parfyonova Y,Popov E,Gavrilov I,Anuchin V,Dubov P,Djakonova Y

更新日期：1998-01-01 00:00:00

abstract：:Stripping of cytoplasm from circulating megakaryocytes (MKs) in the pulmonary capillary bed implicates the lungs as an important site for platelet production in normal physiology. The placenta has been proposed as an alternative location for intrauterine platelet production as fetal lungs are essentially non-functioni...

journal_title：Platelets

authors： Woods MJ,Landon CR,Greaves M,Trowbridge EA

更新日期：1992-01-01 00:00:00

abstract：:Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender,...

journal_title：Platelets

authors： Berlin G,Hammar M,Tapper L,Tynngård N

更新日期：2019-01-01 00:00:00

abstract：:The Multiplate is a popular instrument that measures platelet function using whole blood. Potentially considered a point of care instrument, it is also used by hemostasis laboratories. The instrument is usually utilized to assess antiplatelet medication or as a screen of platelet function. According to the manufacture...

journal_title：Platelets

authors： Chapman K,Favaloro EJ

更新日期：2018-05-01 00:00:00

abstract：:It has recently been demonstrated that both initiators and inhibitors (viz iloprost) of aggregation stimulate the uptake of [(45)Ca(2+)] by human platelets. Since it was postulated that this calcium uptake reflects changes associated with signal transduction, we investigated the role of cAMP-dependent protein kinases ...

journal_title：Platelets

authors： Gill J,Jeremy JY,Mikhailidis DP

更新日期：1993-01-01 00:00:00

abstract：:Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...

journal_title：Platelets

authors： Vila PM,Zafar MU,Badimon JJ

更新日期：2009-12-01 00:00:00

abstract：:The frequency distributions of HPA-1 to HPA-6 and HPA-15 were evaluated in two Brazilian populations from Parana: a mixed population of predominantly Caucasians and a population of Japanese descendants. Genotyping was performed by PCR-SSP in 364 unrelated individuals. Differences in the distribution of HPA highlight d...

journal_title：Platelets

authors： Silvestre APA,Zacarias JMV,Guelsin GAS,Visentainer JEL,Sell AM

更新日期：2017-09-01 00:00:00

abstract：:The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were t...

journal_title：Platelets

authors： Mazurov AV,Pevzner DV,Antonova OA,Byzova TV,Khaspekova SG,Semenov AV,Vlasik TN,Samko AN,Staroverov II,Ruda MY

更新日期：2002-12-01 00:00:00

abstract：:In this study, we have examined whether the platelet Fc-receptor, FcγRII (CD32), is associated with either of the two major platelet membrane glycoproteins, the GPIb-IX complex and the GPIIb-IIIa complex. Monoclonal and polyclonal anti-GPIb-IX complex antibodies inhibited to only a moderate degree (< 40%) the binding ...

journal_title：Platelets

authors： Berndt MC,Mazurov AV,Vinogradov DV,Burns GF,Chesterman CN

更新日期：1993-01-01 00:00:00

abstract：:Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. However, any direct ef...

journal_title：Platelets

authors： Liu Q,Sloan S,Frojmovic MM

更新日期：1999-01-01 00:00:00

abstract：:Prostaglandins stimulate cyclic AMP synthesis in platelets, leading to inhibition of platelet aggregation. Prostaglandin receptors have been identified but knowledge of their pharmacology is limited by the lack of antagonists. Kinetic measurements of prostaglandinregulated cyclic AMP formation provide useful informati...

journal_title：Platelets

authors： Ashby B

更新日期：1990-01-01 00:00:00

abstract：:Prominence has been given recently to the use of platelet-rich plasma (PRP) in combination with bone graft materials for predictably obtaining periodontal regeneration through bioengineering. The purpose of this report was to present clinical, radiographic and re-entry results of a generalized aggressive periodontitis...

journal_title：Platelets

authors： Yilmaz S,Cakar G,Kuru BE,Yildirim B

更新日期：2007-11-01 00:00:00

abstract：:Adenosine diphosphate (ADP) is recognized as an important mediator of platelet aggregation. Transient aggregation at low (< or =1 microM), and sustained aggregation at higher ADP concentrations are consistently observed. Dissociation of platelet aggregates has been described and may explain the reversible component of...

journal_title：Platelets

authors： Maayani S,Tagliente TM,Schwarz T,Craddock-Royal B,Alcala C,Marrero G,Martinez R

更新日期：2001-08-01 00:00:00

abstract：:The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...

journal_title：Platelets

authors： Olas B,Wachowicz B,Tomczak A,Erler J,Stochmal A,Oleszek W

更新日期：2008-02-01 00:00:00

abstract：:Pre-analytical variables interact with standard coagulation parameters. How these variables affect the platelet function analysis is not completely known. How collection site and puncture method affect multiple electrode aggregometry (MEA) and platelet function analyzer (PFA-100®) was compared regarding contact activa...

journal_title：Platelets

authors： Lancé MD,Henskens YM,Nelemans P,Theunissen MH,Oerle RV,Spronk HM,Marcus MA

更新日期：2013-01-01 00:00:00

abstract：:A controversial discussion as to whether human platelets are capable of regulated protein synthesis has been ongoing for over half a century. A previous study has suggested that human platelets synthesize large amounts of interleukin 1beta (IL-1beta) in response to external cues and in a physiologically significant ma...

journal_title：Platelets

authors： Pillitteri D,Bassus S,Boller K,Mahnel R,Scholz T,Westrup D,Wegert W,Kirchmaier CM

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It i...

journal_title：Platelets

authors： Rifaioglu EN,Sen BB,Ekiz Ö,Dogramaci AC

更新日期：2014-01-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced ser...

journal_title：Platelets

authors： Huynh A,Arnold DM,Moore JC,Smith JW,Kelton JG,Nazy I

更新日期：2018-05-01 00:00:00

abstract：:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

journal_title：Platelets

authors： Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

更新日期：2004-02-01 00:00:00

abstract：:In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...

journal_title：Platelets

authors： Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

更新日期：2016-06-01 00:00:00

abstract：:Platelet-surface contact is the first step in thrombus formation. Platelet spreading makes this initial contact irreversible. On the other hand plasma lipids and fibrinogen have been described to activate platelets or promote adhesion. We therefore investigated whether platelet spreading under stagnation-point flow co...

journal_title：Platelets

authors： Reininger AJ,Reininger CB,Agneskirchner J,Scherb H,Spannagl M,Wurzinger LJ

更新日期：1998-01-01 00:00:00

abstract：:Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Diso...

journal_title：Platelets

authors： Maurer-Spurej E,Kahr WH,Carter CJ,Pittendreigh C,Cameron M,Cyr TD

更新日期：2008-08-01 00:00:00

abstract：:Postoperative atrial fibrillation (AF) is a common complication of coronary artery bypass grafting (CABG). The mean platelet volume (MPV) is an important marker of platelet activity and is associated with cardiovascular risk factors. We investigated whether the MPV is associated with the development of AF after CABG. ...

journal_title：Platelets

authors： Erdem K,Ayhan S,Ozturk S,Bugra O,Bozoglan O,Dursin H,Yazici M,Daglar B

更新日期：2014-01-01 00:00:00

abstract：:Thrombocytopenia is one of the most frequent hematologic abnormalities in the neonatal period, affecting about 18-35% of all patients admitted to the Neonatal Intensive Care Unit (NICU), with sepsis being among the most common causes of severe neonatal thrombocytopenia. It is unclear whether decreased platelet product...

journal_title：Platelets

authors： Eissa DS,El-Farrash RA

更新日期：2013-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. The action of LPS is related to the activation of many types of cells, including blood platelets. We examined the effects of different LPSs from Proteus mirabilis (smooth form LPS S1959 and r...

journal_title：Platelets

authors： Zielinski T,Wachowicz B,Saluk-Juszczak J,Kaca W

更新日期：2002-11-01 00:00:00

abstract：:Platelet aggregation and microaggregate formation were measured in samples of stirred whole blood by flow cytometry. Blood samples were stirred in a multi-sample agitator with ADP, fixed and labelled with a platelet-specific CD42a-FITC fluorescent antibody. The blood was then diluted and applied directly to a flow cyt...

journal_title：Platelets

authors： Fox SC,Sasae R,Janson S,May JA,Heptinstall S

更新日期：2004-03-01 00:00:00