A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer.

abstract：:The aims of this study were to evaluate the kinetics of platelet counts and mean platelet volume (MPV) in adults with sepsis and to determine whether the responses are infection-specific. This retrospective cohort study included patients admitted to a tertiary-care teaching hospital with microbiologically proven nosoc...

journal_title：Platelets

authors： Aydemir H,Piskin N,Akduman D,Kokturk F,Aktas E

更新日期：2015-01-01 00:00:00

abstract：:Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which is in line with a morning enhancement of platelet aggregation. We investigated whether platelet inhibition during clopidogrel and aspirin therapy varies during the day. Fifty-nine consecu...

journal_title：Platelets

authors： Kozinski M,Bielis L,Wisniewska-Szmyt J,Boinska J,Stolarek W,Marciniak A,Kubica A,Grabczewska Z,Navarese EP,Andreotti F,Siller-Matula JM,Rosc D,Kubica J

更新日期：2011-01-01 00:00:00

abstract：:Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

journal_title：Platelets

authors： Chen Y,Yang Y,Cheng J,Lu J,Hu W

更新日期：2020-01-01 00:00:00

abstract：:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

journal_title：Platelets

authors： Patrignani P,Patrono C

更新日期：2018-12-01 00:00:00

abstract：:A pathogen-free and standardized xeno-free supplement of growth media is required for the ex vivo propagation of human cells used as advanced therapeutic medicinal products and for clinical translation in regenerative medicine and cell therapies. Human platelet lysate (HPL) made from therapeutic-grade platelet concent...

journal_title：Platelets

authors： Barro L,Burnouf PA,Chou ML,Nebie O,Wu YW,Chen MS,Radosevic M,Knutson F,Burnouf T

更新日期：2020-11-29 00:00:00

abstract：:A number of hematopoietic growth factors and other cytokines are capable of altering platelet production and function. Enhancement of these processes may be exploited to ameliorate bleeding propensity in thrombocytopenic patients. Under certain circumstances, cytokines may have adverse effects on the hemostatic system...

journal_title：Platelets

authors： Burstein SA

更新日期：1997-01-01 00:00:00

abstract：:Activated platelets serve as a catalyst for thrombin generation and a source of vasoactive and mitogenic factors affecting vascular remodeling. Oral menopausal hormone treatments (MHT) may carry greater thrombotic risk than transdermal products. This study compared effects of oral and transdermal MHT on platelet chara...

journal_title：Platelets

authors： Miller VM,Lahr BD,Bailey KR,Heit JA,Harman SM,Jayachandran M

更新日期：2016-01-01 00:00:00

abstract：:The ram gene was isolated from a rat megakaryocyte cDNA library and encodes a GTP-binding protein with a Mr of 25 000. In order to clarify the presence of the ram protein (ram p25) in human platelets, we tried to purify ram p25 from the sodium cholate extract of human platelet membranes by a combination of DEAE-Sephac...

journal_title：Platelets

authors： Nagata K,Okano Y,Suzuki T,Nozawa Y

更新日期：1993-01-01 00:00:00

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:Outcomes of platelet function tests are highly dependent on the type of blood anticoagulant used. The primary objective of this study was to clinically evaluate the platelet function after dual antiplatelet therapy using two different types of anticoagulant (citrate and hirudin). We compared data obtained from multipl...

journal_title：Platelets

authors： Zhang HZ,Yu LH,Kim MH

更新日期：2013-01-01 00:00:00

abstract：:Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...

journal_title：Platelets

authors： Lim CC,Patel DK,Bakhtiari A,Subrayan V

更新日期：2013-01-01 00:00:00

abstract：:Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet f...

journal_title：Platelets

authors： Törnudd M,Ramström S,Kvitting JE,Alfredsson J,Pihl R,Berg S

更新日期：2021-01-02 00:00:00

abstract：:Platelet aggregation and microaggregate formation were measured in samples of stirred whole blood by flow cytometry. Blood samples were stirred in a multi-sample agitator with ADP, fixed and labelled with a platelet-specific CD42a-FITC fluorescent antibody. The blood was then diluted and applied directly to a flow cyt...

journal_title：Platelets

authors： Fox SC,Sasae R,Janson S,May JA,Heptinstall S

更新日期：2004-03-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced ser...

journal_title：Platelets

authors： Huynh A,Arnold DM,Moore JC,Smith JW,Kelton JG,Nazy I

更新日期：2018-05-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...

journal_title：Platelets

authors： Meyer T,Amaya M,Desai H,Robles-Carrillo L,Hatfield M,Francis JL,Amirkhosravi A

更新日期：2010-01-01 00:00:00

abstract：:Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...

journal_title：Platelets

authors： Bath PM,May J,Heptinstall S

更新日期：2018-07-01 00:00:00

abstract：:In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support ...

journal_title：Platelets

authors： Jenner S,Sage SO

更新日期：2000-06-01 00:00:00

abstract：:Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional labor...

journal_title：Platelets

authors： Bigalke B,Stellos K,Geisler T,Seizer P,Mozes V,Gawaz M

更新日期：2010-01-01 00:00:00

abstract：:In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...

journal_title：Platelets

authors： Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

更新日期：2016-06-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:The H(1)-histamine receptor antagonist Dithaden(R) inhibited in a dose-dependent manner, human platelet aggregation in vitro that was induced with stimuli in the following rank order of potency: thrombin > A23187 > adrenaline > ADP. The aggregation of platelets in plasma induced with adrenaline was inhibited by Dithia...

journal_title：Platelets

authors： Nosál' R,Jancinová V,Danihelova E

更新日期：1997-01-01 00:00:00

abstract：:Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...

journal_title：Platelets

authors： Zhang C,Neelamegham S

更新日期：2017-07-01 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:D-glucono-1,4-lactone, sodium D-gluconate and calcium D-glucarate are non-toxic glucose derivatives occurring naturally in fruits and vegetables. Calcium D-glucarate is promoted as an orally bioavailability dietary supplement with potential chemopreventive activity without adverse effects. Despite many commercial appl...

journal_title：Platelets

authors： Saluk-Juszczak J

更新日期：2010-01-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 ...

journal_title：Platelets

authors： Falet H

更新日期：2013-01-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. Impaired fasting glucose (IFG) is probably a frequent glycemic disorder in the general population and is considered as a prediabetic state. The present study was designed to evaluate MPV in subjects wi...

journal_title：Platelets

authors： Coban E,Bostan F,Ozdogan M

更新日期：2006-02-01 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00