Effects of age, gender and menstrual cycle on platelet function assessed by impedance aggregometry.


:Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender, and phases of the menstrual cycle by use of impedance aggregometry with Multiplate. In the first part of the study, platelet function was assessed in 60 healthy individuals (30 men and 30 women) in each of three age groups (20-25, 40-45, and 60-65 years). In the second part of the study, the platelet function was analyzed on four occasions during the menstrual cycle in women without oral contraceptives (OCs) (n = 17) and compared to 19 women on OCs and 18 men of similar age (20-40 years). For the women on OCs, aggregation was analyzed once during the tablet-free week and once late during the period with OCs. The men were sampled once. Women of younger age (<45 years) had significantly higher agonist-induced aggregation response than both men and post-menopausal women (60-65 years). The agonist-induced aggregation response did not differ between phases of the menstrual cycle or OC use. The results suggest that estradiol and/or progesterone affect spontaneous aggregation since it was found to be lowest in the mid-luteal phase. Spontaneous aggregation was significantly lower in women on OCs than in both men and women without OCs. Our findings indicate that fertile age is associated with higher aggregation response capacity of the platelets, possibly to prevent excessive bleeding during menstruation, but this response capacity is not altered during the menstrual cycle or by use of OCs.






Berlin G,Hammar M,Tapper L,Tynngård N




Has Abstract


2019-01-01 00:00:00












  • A new variant of Glanzmann's thrombasthenia with defective activation-dependent fibrinogen binding and altered expression of epitopes for several monoclonal antibodies against GP IIb-IIIa.

    abstract::In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...


    pub_type: 杂志文章


    authors: Meyer M,Thieme A,Jablonka B,Just M,Ströhl C,Schellenberg I,Kirchmaier CM

    更新日期:1996-01-01 00:00:00

  • Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer's disease.

    abstract::Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...


    pub_type: 临床试验,杂志文章


    authors: Liang QC,Jin D,Li Y,Wang RT

    更新日期:2014-01-01 00:00:00

  • Platelet activation at the onset of human endotoxemia is undetectable in vivo.

    abstract::Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...


    pub_type: 杂志文章


    authors: Schrottmaier WC,Kral JB,Zeitlinger M,Salzmann M,Jilma B,Assinger A

    更新日期:2016-07-01 00:00:00

  • Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma.

    abstract::Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...


    pub_type: 杂志文章


    authors: Pennings GJ,Yong AS,Wong C,Al-Tamimi M,Gardiner EE,Andrews RK,Kritharides L

    更新日期:2014-01-01 00:00:00

  • Comparison of treatments for persistent/chronic immune thrombocytopenia: a systematic review and network meta-analysis.

    abstract::Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...


    pub_type: 杂志文章,meta分析


    authors: Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

    更新日期:2019-01-01 00:00:00

  • Functional roles of membrane glycoprotein CD36.

    abstract::Cell-cell and cell-extracellular matrix interactions are mediated by a number of membrane glycoproteins. On the basis of structural homologies, several families of cell adhesion molecules (integrins, selectins, immunoglobulins, cadherins, leucine-rich glycoproteins) have been established. Since 1991, a new family of C...


    pub_type: 杂志文章


    authors: Daviet L,McGregor JL

    更新日期:1996-01-01 00:00:00

  • Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias.

    abstract::The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise...


    pub_type: 杂志文章


    authors: Salim JP,Glembotsky AC,Lev PR,Marin Oyarzún CP,Goette NP,Molinas FC,Marta RF,Heller PG

    更新日期:2017-09-01 00:00:00

  • Thrombocytopenia model with minimal manipulation of blood cells allowing whole blood assessment of platelet function.

    abstract::In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...


    pub_type: 杂志文章


    authors: Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

    更新日期:2016-06-01 00:00:00

  • Capture of platelets to the endothelium of the femoral vein is mediated by CD62P and CD162.

    abstract::Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...


    pub_type: 杂志文章


    authors: Slotta JE,Braun OO,Menger MD,Thorlacius H

    更新日期:2009-11-01 00:00:00

  • The efficacy and safety of CYP2C19 genotype-guided antiplatelet therapy compared with conventional antiplatelet therapy in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled tri

    abstract::Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...


    pub_type: 杂志文章


    authors: Lyu SQ,Yang YM,Zhu J,Wang J,Wu S,Zhang H,Shao XH,Ren JM

    更新日期:2020-11-16 00:00:00

  • Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now?

    abstract::A large number of patients require antiplatelet therapy (mainly aspirin and/or clopidogrel). Recent studies suggest that the combination of these agents is useful in patients with acute coronary syndrome and after percutaneous coronary intervention with stent placement. On the other hand, bleeding complications, most ...


    pub_type: 杂志文章,评审


    authors: Liberopoulos EN,Elisaf MS,Tselepis AD,Archimandritis A,Kiskinis D,Cokkinos D,Mikhailidis DP

    更新日期:2006-02-01 00:00:00

  • Prostaglandin Regulation of Cyclic AMP Metabolism in Human Platelets.

    abstract::Prostaglandins stimulate cyclic AMP synthesis in platelets, leading to inhibition of platelet aggregation. Prostaglandin receptors have been identified but knowledge of their pharmacology is limited by the lack of antagonists. Kinetic measurements of prostaglandinregulated cyclic AMP formation provide useful informati...


    pub_type: 杂志文章


    authors: Ashby B

    更新日期:1990-01-01 00:00:00

  • Cloning of the cDNA for murine von Willebrand factor and identification of orthologous genes reveals the extent of conservation among diverse species.

    abstract::Interaction of von Willebrand factor (VWF) with circulating platelets promotes hemostasis when a blood vessel is injured. The A1 domain of VWF is responsible for the initial interaction with platelets and is well conserved among species. Knowledge of the cDNA and genomic DNA sequences for human VWF allowed us to predi...


    pub_type: 杂志文章


    authors: Chitta MS,Duhé RJ,Kermode JC

    更新日期:2007-05-01 00:00:00

  • New insights into thrombopoiesis in neonatal sepsis.

    abstract::Thrombocytopenia is one of the most frequent hematologic abnormalities in the neonatal period, affecting about 18-35% of all patients admitted to the Neonatal Intensive Care Unit (NICU), with sepsis being among the most common causes of severe neonatal thrombocytopenia. It is unclear whether decreased platelet product...


    pub_type: 杂志文章


    authors: Eissa DS,El-Farrash RA

    更新日期:2013-01-01 00:00:00

  • The polyphenol-rich extract from grape seeds inhibits platelet signaling pathways triggered by both proteolytic and non-proteolytic agonists.

    abstract::Mechanisms involved in the reduction of blood platelet functions by various plant extract, including the grape seeds extract (rich in phenolic compounds, a mixture of about 95% oligomeric phenols; GSE) are still unclear. In the literature there are few papers describing studies on the effects of GSE on selected elemen...


    pub_type: 杂志文章


    authors: Olas B,Wachowicz B,Stochmal A,Oleszek W

    更新日期:2012-01-01 00:00:00

  • Microparticles in deep venous thrombosis, antiphospholipid syndrome and Factor V Leiden.

    abstract::Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...


    pub_type: 杂志文章


    authors: Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

    更新日期:2009-09-01 00:00:00

  • Thyroid and celiac diseases autoantibodies in patients with adult chronic idiopathic thrombocytopenic purpura.

    abstract::The association of chronic idiopathic thrombocytopenic purpura (cITP) and thyroid autoimmune diseases (TAD) is a known but an uncommon condition. Celiac disease (CD), which is characterized by malabsorption and villous atrophy that occur as a consequence of the ingestion of wheat gluten may also be related to other au...


    pub_type: 杂志文章


    authors: Altintas A,Pasa S,Cil T,Bayan K,Gokalp D,Ayyildiz O

    更新日期:2008-06-01 00:00:00

  • Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow?

    abstract::Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...


    pub_type: 杂志文章


    authors: Jung SM,Sonoda M,Tsuji K,Jimi A,Nomura S,Kanaji T,Moroi M

    更新日期:2010-01-01 00:00:00

  • Desaggregation by Verapamil, Sodium Nitroprusside and PGE(1), of Rabbit Platelets Aggregated by PAF-acether. A Morphological and Biochemical Study.

    abstract::The action of sodium nitroprusside, an activator of guanylate cyclase, on rabbit platelets stimulated with PAF-acether, was studied singly or in combination with verapamil. Not only did sodium nitroprusside in the range 10(-6) to 10(-4) M inhibit PAF-acether induced aggregation, but it also brought about desaggregatio...


    pub_type: 杂志文章


    authors: Khan SN,Smith AD,Neal CR,Pittilo RM

    更新日期:1993-01-01 00:00:00

  • Cilostazol inhibits platelet-leukocyte interaction by suppression of platelet activation.

    abstract::The influence of three anti-platelet drugs, cilostazol, aspirin, and tirofiban, was investigated on platelet-leukocyte interaction by flow cytometry. When platelets and leukocytes were pre-incubated with anti-platelet drugs and stimulated by thrombin or collagen, cilostazol was found to inhibit platelet adhesion to mo...


    pub_type: 杂志文章


    authors: Ito H,Miyakoda G,Mori T

    更新日期:2004-08-01 00:00:00

  • Thrombin-induced interleukin 1beta synthesis in platelet suspensions: impact of contaminating leukocytes.

    abstract::A controversial discussion as to whether human platelets are capable of regulated protein synthesis has been ongoing for over half a century. A previous study has suggested that human platelets synthesize large amounts of interleukin 1beta (IL-1beta) in response to external cues and in a physiologically significant ma...


    pub_type: 杂志文章


    authors: Pillitteri D,Bassus S,Boller K,Mahnel R,Scholz T,Westrup D,Wegert W,Kirchmaier CM

    更新日期:2007-03-01 00:00:00

  • A new case with Hermansky-Pudlak syndrome type 9, a rare cause of syndromic albinism with severe defect of platelets dense bodies.

    abstract::Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...


    pub_type: 杂志文章


    authors: Michaud V,Fiore M,Coste V,Huguenin Y,Bordet JC,Plaisant C,Lasseaux E,Morice-Picard F,Arveiler B

    更新日期:2020-04-03 00:00:00

  • Generation of reactive oxygen species in blood platelets.

    abstract::The generation of superoxide anion radicals (O2*-) and the other reactive oxygen species (ROS) was estimated by means of cytochrome c reduction and chemiluminescence, as well in resting blood platelets and in platelets stimulated by thrombin in the presence or absence of some inhibitors of pathways involved in platele...


    pub_type: 杂志文章


    authors: Wachowicz B,Olas B,Zbikowska HM,Buczyński A

    更新日期:2002-05-01 00:00:00

  • Polysaccharide part of Proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen.

    abstract::Lipopolysaccharide (LPS, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. The action of LPS is related to the activation of many types of cells, including blood platelets. We examined the effects of different LPSs from Proteus mirabilis (smooth form LPS S1959 and r...


    pub_type: 杂志文章


    authors: Zielinski T,Wachowicz B,Saluk-Juszczak J,Kaca W

    更新日期:2002-11-01 00:00:00

  • The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences.

    abstract::Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...


    pub_type: 临床试验,杂志文章


    authors: Park BJ,Shim JY,Lee HR,Jung DH,Lee JH,Lee YJ

    更新日期:2012-01-01 00:00:00

  • Platelet activation in subjects with impaired glucose tolerance.

    abstract::Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...


    pub_type: 杂志文章


    authors: Coban E,Kucuktag S,Basyigit S

    更新日期:2007-12-01 00:00:00

  • The value of proteomics for the diagnosis of a platelet-related bleeding disorder.

    abstract::Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Diso...


    pub_type: 杂志文章


    authors: Maurer-Spurej E,Kahr WH,Carter CJ,Pittendreigh C,Cameron M,Cyr TD

    更新日期:2008-08-01 00:00:00

  • Thrombocytopenia and GBA gene mutation in a patient with adult type 1 Gaucher disease.

    abstract::A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...


    pub_type: 信件


    authors: Wan L,Wu H,Xie F,Nie Y

    更新日期:2017-12-01 00:00:00

  • Rapid isolation and purification of functional platelet mitochondria using a discontinuous Percoll gradient.

    abstract::The isolation of mitochondria is gaining importance in experimental and clinical laboratory settings. The mitochondrion is known as the powerhouse of the cell as it produces the energy to power most cellular functions but is also involved in many cellular processes. Of interest, mitochondria and mitochondrial componen...


    pub_type: 杂志文章


    authors: Léger JL,Jougleux JL,Savadogo F,Pichaud N,Boudreau LH

    更新日期:2020-01-01 00:00:00

  • Recovery of platelet reactivity following cessation of either aspirin or ticagrelor in patients treated with dual antiplatelet therapy following percutaneous coronary intervention: a GLOBAL LEADERS substudy.

    abstract::Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study comp...


    pub_type: 杂志文章


    authors: Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KG

    更新日期:2020-12-26 00:00:00