Abstract:
:The risk and benefit of GP-IIb/IIIa Inhibition (GPI) in combination with recent antiplatelet regimens in acute coronary syndromes (ACS) remain unassessed. The advent of fast-acting highly active oral P2Y12 inhibitors questions the additional value and risk of their association with GPI. We studied the effect of GPI in combination with prasugrel and ticagrelor, compared to clopidogrel on major bleeding in pivotal randomized controlled trials in the setting of ACS, using a meta-analytic approach. A similar analysis, further including the comparison of a double versus standard dose clopidogrel regimen, was performed for the risk of the primary efficacy endpoint. The combination of GPI and recent P2Y12 inhibitors was associated with a similar risk of bleeding as compared with GPI and the standard clopidogrel regimen (RR 0.92 [0.74; 1.13]). The benefit of recent regimens, including double dose clopidogrel, in reducing the primary ischemic endpoint (RR 0.86 [0.78; 0.94]) persisted in those treated with GPI. Although GPI use was associated with a consistent increase in the risk of bleeding in both recent (RR 1.27 [1.05-1.55]) and standard regimens (RR 2.01 [1.64-2.47]), the relative magnitude of such an increase was lower in association with prasugrel or ticagrelor as compared with clopidogrel. The risk of bleeding using a combination of GPI and oral antiplatelet regimens is mainly related to the use of GPI and not the oral antiplatelet regimen. Considering the absence of increased risk of bleeding and the persistence of the benefit of recent P2Y12 regimens in combination with GPI as compared with the standard clopidogrel regimen, the use of such a combination within the guidelines is supported by our findings.
journal_name
Plateletsjournal_title
Plateletsauthors
Roule V,Agueznai M,Sabatier R,Blanchart K,Lemaître A,Ardouin P,Collet JP,Milliez P,Montalescot G,Beygui Fdoi
10.1080/09537104.2016.1218453subject
Has Abstractpub_date
2017-03-01 00:00:00pages
174-181issue
2eissn
0953-7104issn
1369-1635journal_volume
28pub_type
杂志文章,meta分析,评审相关文献
PLATELETS文献大全abstract::Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender,...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1466387
更新日期:2019-01-01 00:00:00
abstract::Studies on markers for bleeding risk among thrombocytopenic cancer patients are lacking. This prospective observational cohort study investigated whether platelet parameters and a standardised bleeding questionnaire predicted bleeding or prophylactic platelet transfusions in patients with cancer and thrombocytopenia. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1131814
更新日期:2016-09-01 00:00:00
abstract::Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been...
journal_title:Platelets
pub_type: 杂志文章,meta分析,评审
doi:10.1080/09537104.2018.1442567
更新日期:2018-05-01 00:00:00
abstract::Adrenaline is a platelet activator having a resting plasma concentration of <1 nmol/l that increases to a few nmol/l during stress. However, most in vitro assays only detect effects of adrenaline in micromolar concentrations. This makes it difficult to estimate the relevance of in vitro data for the in vivo situation....
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.672780
更新日期:2013-01-01 00:00:00
abstract::Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...
journal_title:Platelets
pub_type: 临床试验,杂志文章
doi:10.3109/09537104.2011.589014
更新日期:2012-01-01 00:00:00
abstract::Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. T...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2016.1203401
更新日期:2017-06-01 00:00:00
abstract::Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1850670
更新日期:2020-12-21 00:00:00
abstract::Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2014.887668
更新日期:2015-01-01 00:00:00
abstract::Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1478400
更新日期:2019-01-01 00:00:00
abstract::The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1678118
更新日期:2020-08-17 00:00:00
abstract::Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537104.2018.1528347
更新日期:2019-01-01 00:00:00
abstract::Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903497549
更新日期:2010-01-01 00:00:00
abstract::Recombinant human erythropoietin is a successful treatment for the anaemia of renal failure. Its use has however been associated with thromboembolic complications. Changes in platelet number and behaviour in vitro were studied in: (1) 23 haemodialysis patients, and 10 continuous ambulatory peritoneal dialysis patients...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109209013168
更新日期:1992-01-01 00:00:00
abstract::Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the re...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1445835
更新日期:2019-01-01 00:00:00
abstract::Flow cytometric analysis of human platelets from healthy volunteers by high-resolution immunophenotyping accomplished with enzymatic amplification staining revealed the expression of CD34. Assessment of the platelets with five different monoclonal antibodies to the three different classes of CD34 epitopes suggested th...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953710031000080577
更新日期:2003-03-01 00:00:00
abstract::In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100050057657
更新日期:2000-06-01 00:00:00
abstract::Activated platelets serve as a catalyst for thrombin generation and a source of vasoactive and mitogenic factors affecting vascular remodeling. Oral menopausal hormone treatments (MHT) may carry greater thrombotic risk than transdermal products. This study compared effects of oral and transdermal MHT on platelet chara...
journal_title:Platelets
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/09537104.2015.1023273
更新日期:2016-01-01 00:00:00
abstract::We prospectively investigated the prevalence of Helicobacter pylori (H. pylori) infection in a cohort of 54 adult Serbian patients with chronic idiopathic thrombocytopenic purpura (ITP), and examined the effects of its eradication on their platelet counts. H. pylori infection was diagnosed in 39/54 (72.2%) patients, u...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500462487
更新日期:2006-06-01 00:00:00
abstract::Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2016.1153621
更新日期:2016-09-01 00:00:00
abstract::The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701694144
更新日期:2008-03-01 00:00:00
abstract::Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1430358
更新日期:2018-11-01 00:00:00
abstract::Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100903096676
更新日期:2009-09-01 00:00:00
abstract::We measured and compared the levels of microparticles, chemokines, cell adhesion molecules and platelet activation markers with a view to developing a better understanding of their potential contributions to the pathophysiology of progressive systemic sclerosis (PSS, scleroderma). The concentrations of all the factors...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701882038
更新日期:2008-05-01 00:00:00
abstract::Microalbuminuria is the best predictor of diabetic nephropathy development in patients with type II diabetes mellitus (DM). It is also accepted as an indicator of diabetic microangiopathy. Increased activation of platelets has been suggested to be involved in the pathogenesis of vascular complications. In light of the...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.634934
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109409005529
更新日期:1994-01-01 00:00:00
abstract::Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537100903261379
更新日期:2009-12-01 00:00:00
abstract::Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1119814
更新日期:2016-07-01 00:00:00
abstract::FVIII is an important cofactor in the tenase coagulation factor complex, lack of FVIII causes severe bleeding, whereas high FVIII levels seem to be associated with venous and arterial thromboembolism. Resting platelets do not bind FVIII, but activated platelets bind unactivated FVIII if vWF is not present. We investig...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600747035
更新日期:2006-11-01 00:00:00
abstract::The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701708506
更新日期:2008-02-01 00:00:00
abstract::Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500163457
更新日期:2005-11-01 00:00:00