Abstract:
:Previous investigations from our laboratory identified the ultrastructural pathology and cytochemistry of macrothrombocytes (MTC) from patients with the X-linked, G208S varient of the GATA-1 mutation.A subsequent biochemical study of the MTC cytoskeletal proteins using polyacrylamide gel electrophoresis and western blot analysis revealed the MTC were deficient in the high-molecular weight, actin binding protein, talin. The present study has used immunofluorescent techniques to further characterize the talin deficiency. Results confirm that the GATA-1, G208S MTC are deficient in talin, and what little is present relocates to the undersurface of the plasma membrane following activations where it associates with adhesion plaques.
journal_name
Plateletsjournal_title
Plateletsauthors
White JG,Burris SM,Crowe BRdoi
10.1080/09537100902818344subject
Has Abstractpub_date
2009-05-01 00:00:00pages
216-24issue
3eissn
0953-7104issn
1369-1635pii
911117877journal_volume
20pub_type
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