The effect of high dose simvastatin on, platelet size in patients with, type 2 diabetes mellitus.

abstract：:Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or '...

journal_title：Platelets

authors： Gachet C,Hechler B,Léon C,Vial C,Ohlmann P,Cazenave JP

更新日期：1996-01-01 00:00:00

abstract：:The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...

journal_title：Platelets

authors： Gabbasov Z,Parfyonova Y,Popov E,Gavrilov I,Anuchin V,Dubov P,Djakonova Y

更新日期：1998-01-01 00:00:00

abstract：:Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or ...

journal_title：Platelets

authors： Toya T,Yoshimi A,Morioka T,Arai S,Ichikawa M,Usuki K,Kurokawa M

更新日期：2014-01-01 00:00:00

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:SIRT1, a class III histone deacetylase, is critically involved in cellular response to stress and modulates cardiovascular risk factors. However, its role in thrombus formation is largely unknown. Thus, this study investigated the effect of SIRT1 on pulmonary thrombus formation, and then identified its role in the mod...

journal_title：Platelets

authors： Kim YH,Bae JU,Kim IS,Chang CL,Oh SO,Kim CD

更新日期：2016-12-01 00:00:00

abstract：:Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...

journal_title：Platelets

authors： Lyu SQ,Yang YM,Zhu J,Wang J,Wu S,Zhang H,Shao XH,Ren JM

更新日期：2020-11-16 00:00:00

abstract：:The aim of this survey was to describe drug-induced immune thrombocytopenia (ITP) reported in the French PharmacoVigilance database (FPVD) and to discuss the drugs involved. The request to the FPVD used the seven most accurate diagnosis codes to identify ITP. The study was restricted to cases reported from 2007 to 201...

journal_title：Platelets

authors： Moulis G,Sommet A,Sailler L,Lapeyre-Mestre M,Montastruc JL,French Association Of Regional Pharmacovigilance Centers.

更新日期：2012-01-01 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from seco...

journal_title：Platelets

authors： Rejtö L,Schlammadinger A,László P,Kiss A,Telek B,Boda Z

更新日期：2000-02-01 00:00:00

abstract：:The action of inorganic forms of selenium (Se) on blood platelet aggregation, secretion and the arachidonate pathway in vitro was studied. It was shown that sodium selenite, after 30 min preincubation, inhibited platelet aggregation induced by 0.1 U/ml of thrombin and by 10 microM ADP (about 30% inhibition of aggregat...

journal_title：Platelets

authors： Zbikowska HM,Wachowicz B,Krajewski T

更新日期：1999-01-01 00:00:00

abstract：:Platelet aggregation and microaggregate formation were measured in samples of stirred whole blood by flow cytometry. Blood samples were stirred in a multi-sample agitator with ADP, fixed and labelled with a platelet-specific CD42a-FITC fluorescent antibody. The blood was then diluted and applied directly to a flow cyt...

journal_title：Platelets

authors： Fox SC,Sasae R,Janson S,May JA,Heptinstall S

更新日期：2004-03-01 00:00:00

abstract：:Diabetic patients are at higher risk of development of cardiovascular complications than the general population. The role of platelets in the pathogenesis of these complications is still controversial, it being difficult to ascertain whether altered platelet function is a cause or consequence of vascular complications...

journal_title：Platelets

authors： Rotondo S,Cerletti C,Gaetano G,Tascione E

更新日期：1993-01-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...

journal_title：Platelets

authors： Pennings GJ,Yong AS,Wong C,Al-Tamimi M,Gardiner EE,Andrews RK,Kritharides L

更新日期：2014-01-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...

journal_title：Platelets

authors： Michaud V,Fiore M,Coste V,Huguenin Y,Bordet JC,Plaisant C,Lasseaux E,Morice-Picard F,Arveiler B

更新日期：2020-04-03 00:00:00

abstract：:Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in atherosclerosis, there exists an increased risk for i...

journal_title：Platelets

authors： Przyborowski K,Kassassir H,Wojewoda M,Kmiecik K,Sitek B,Siewiera K,Zakrzewska A,Rudolf AM,Kostogrys R,Watala C,Zoladz JA,Chlopicki S

更新日期：2017-11-01 00:00:00

abstract：:The present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 wo...

journal_title：Platelets

authors： Yazici S,Yazici M,Erer B,Erer B,Calik Y,Ozhan H,Ataoglu S

更新日期：2010-01-01 00:00:00

abstract：:Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm3) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adul...

journal_title：Platelets

authors： Dhanoa A,Rajasekaram G,Hassan SS,Ramadas A,Azreen Adnan NA,Lau CF,Chan TS,Ngim CF

更新日期：2017-11-01 00:00:00

abstract：:Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study comp...

journal_title：Platelets

authors： Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KG

更新日期：2020-12-26 00:00:00

abstract：:Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...

journal_title：Platelets

authors： Park BJ,Shim JY,Lee HR,Jung DH,Lee JH,Lee YJ

更新日期：2012-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease. Since the prevalence of NAFLD in overweight/obese people is rather high, there is a general concern about the possibility that NAFLD may have an association with cardiovascular risk factors and atherosclerosis. Mean platelet volume (MPV) i...

journal_title：Platelets

authors： Shin WY,Jung DH,Shim JY,Lee HR

更新日期：2011-01-01 00:00:00

abstract：:A number of hematopoietic growth factors and other cytokines are capable of altering platelet production and function. Enhancement of these processes may be exploited to ameliorate bleeding propensity in thrombocytopenic patients. Under certain circumstances, cytokines may have adverse effects on the hemostatic system...

journal_title：Platelets

authors： Burstein SA

更新日期：1997-01-01 00:00:00

abstract：:Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. However, any direct ef...

journal_title：Platelets

authors： Liu Q,Sloan S,Frojmovic MM

更新日期：1999-01-01 00:00:00

abstract：:The typical data presentation by flow cytometry of platelet suspensions stimulated with calcium ionophore A-23187, thrombin, C5b-9, or other agonists shows a unimodal decrease (or 'left-shift') in forward angle light scatter. Many reports in the literature interpret these findings as indicative of the appearance of sm...

journal_title：Platelets

authors： Bode AP,Hickerson DH

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...

journal_title：Platelets

authors： Mathai J,Resmi KR,Sulochana PV,Sathyabhama S,Baby Saritha G,Krishnan LK

更新日期：2006-09-01 00:00:00

abstract：:Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

journal_title：Platelets

authors： Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It i...

journal_title：Platelets

authors： Rifaioglu EN,Sen BB,Ekiz Ö,Dogramaci AC

更新日期：2014-01-01 00:00:00

abstract：:This study investigated the mechanism by which treatment of the CHRF 288-11 megakaryoblastic cell line with phorbol myristate acetate caused a transient increase in adhesion. The adhesion to tissue culture plastic occurred within 4 h and could be reversed by treatment with RGDS-peptide suggesting the involvement of on...

journal_title：Platelets

authors： Conran N,Hemming FW

更新日期：1999-01-01 00:00:00