Abstract:
:Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The relative content of arachidonic acid (AA) decreased in platelets from all individuals, whereas the content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increased. Also in plasma, the relative content of EPA and DHA increased, while the change in AA content was small but variable. Generally, the platelet content of oleic acid increased while the linoleic acid decreased. Intake of seal oil decreased platelet aggregation induced by microbubbles. A significant correlation between aggregation in platelet-rich plasma (PRP) and the AA content in platelets was shown, while there was a significant negative correlation between oleic acid content and platelet aggregation. In whole blood, however, seal oil intake did not result in less platelet aggregation using ADP and U-46619 as agonists.
journal_name
Plateletsjournal_title
Plateletsauthors
Bakken AM,Hervig T,Thorsen T,Holmsen Hdoi
10.3109/09537109509023564subject
Has Abstractpub_date
1995-01-01 00:00:00pages
259-64issue
5eissn
0953-7104issn
1369-1635journal_volume
6pub_type
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