Abstract:
:Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy controls. In addition, we investigated underlying causes in postpartum hemorrhage that begin the event. The present study was conducted at the Dicle University School of Medicine. Forty-eight patients with SS and 50 age-matched female healthy controls were included. Biochemical and hormonal variables were measured, as was platelet function by means of closure times (PFA-100 testing using collagen plus epinephrine and collagen plus ADP), von Willebrand factor (vWF) level, prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR), and coagulation factors. Although PT and INR were significantly higher in patients with SS (both P<0.01), aPTT and levels of fibrinogen, vWF, and factors II, V, VII, VIII, IX, X, XI, and XII did not differ significantly. Closure times with collagen/epinephrine and collagen/ADP also did not differ significantly between patients with SS and control patients. The nonspecific etiology and presence of excessive postpartum hemorrhage in patients with SS suggest that coagulation disorders may play a role in their predisposition to bleeding. The increased PT and INR noted might implicate bleeding diathesis as the underlying etiology, although no significant decreases were noted in factor levels. Further studies are needed to elucidate this complex mechanism of this disorder.
journal_name
Plateletsjournal_title
Plateletsauthors
Gokalp D,Tuzcu A,Bahceci M,Ayyildiz O,Erdemoglu M,Alpagat Gdoi
10.3109/09537104.2010.525722subject
Has Abstractpub_date
2011-01-01 00:00:00pages
92-7issue
2eissn
0953-7104issn
1369-1635journal_volume
22pub_type
杂志文章相关文献
PLATELETS文献大全abstract::Platelets play a key role in thrombotic vascular occlusion at the side of an atherosclerotic plaque. Malondialdehyde (MDA) derivatives are components of oxidized LDL. Recent studies suggest enhanced adhesion of platelets on oxidized LDL, but evidence of MDA-modified LDL contribution to enhanced platelet adhesion is mi...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500261590
更新日期:2006-03-01 00:00:00
abstract::Recent studies suggest that anti-platelet agents are not equally effective in all individuals. We have developed a new method to evaluate the effect of anti-platelet drugs using the cone and plate(let) analyzer (CPA) test. The method is based on the ability of activators to reduce platelet adhesion under flow conditio...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100400028800
更新日期:2005-08-01 00:00:00
abstract::Platelet activation occurs in an endothelium-dependent flow-mediated dilation (FMD) impairment environment. The aim of this study was to explore the association between platelet reactivity and brachial artery FMD in individuals without established cardiovascular disease (controls) and acute myocardial infarction (AMI)...
journal_title:Platelets
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/09537104.2011.604805
更新日期:2012-01-01 00:00:00
abstract::High on-treatment platelet reactivity (HTPR) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). The antiplatelet effect and safety of prasugrel was compared to that of double-dose clopidogrel in patients with stable coronary artery disease or acute coronary syndrome (ACS...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.3109/09537104.2013.845874
更新日期:2014-01-01 00:00:00
abstract::Platelet aggregation is usually measured by a spectroscopic method using an aggregometer. However, when the process of platelet aggregation is followed by the changes in light transmission of platelet-rich plasma (PRP), factors such as platelet deformation or changes in plasma permeability must be taken into considera...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109209003395
更新日期:1992-01-01 00:00:00
abstract::The aim of the study was to evaluate diurnal changes of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) concentrations in relation to on-treatment platelet reactivity. The study group included 51 patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention and d...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1693037
更新日期:2020-10-02 00:00:00
abstract::Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet f...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1719992
更新日期:2021-01-02 00:00:00
abstract::Activated platelets serve as a catalyst for thrombin generation and a source of vasoactive and mitogenic factors affecting vascular remodeling. Oral menopausal hormone treatments (MHT) may carry greater thrombotic risk than transdermal products. This study compared effects of oral and transdermal MHT on platelet chara...
journal_title:Platelets
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/09537104.2015.1023273
更新日期:2016-01-01 00:00:00
abstract::Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...
journal_title:Platelets
pub_type: 临床试验,杂志文章
doi:10.3109/09537104.2013.831064
更新日期:2014-01-01 00:00:00
abstract::Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1732328
更新日期:2021-01-02 00:00:00
abstract:BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1754383
更新日期:2020-05-18 00:00:00
abstract::The typical data presentation by flow cytometry of platelet suspensions stimulated with calcium ionophore A-23187, thrombin, C5b-9, or other agonists shows a unimodal decrease (or 'left-shift') in forward angle light scatter. Many reports in the literature interpret these findings as indicative of the appearance of sm...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100050129279
更新日期:2000-08-01 00:00:00
abstract::Studies on markers for bleeding risk among thrombocytopenic cancer patients are lacking. This prospective observational cohort study investigated whether platelet parameters and a standardised bleeding questionnaire predicted bleeding or prophylactic platelet transfusions in patients with cancer and thrombocytopenia. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1131814
更新日期:2016-09-01 00:00:00
abstract::Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. However, any direct ef...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109975889
更新日期:1999-01-01 00:00:00
abstract::The present study had two goals: first, to give a detailed description of a reliable method for full kinetic analysis of serotonin transporter (5HTt) on the membrane of human platelets, and second, as a main issue, to report on physiological influences on kinetic characteristics of this transmembrane transport on a la...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.487582
更新日期:2010-01-01 00:00:00
abstract::Pre-analytical variables interact with standard coagulation parameters. How these variables affect the platelet function analysis is not completely known. How collection site and puncture method affect multiple electrode aggregometry (MEA) and platelet function analyzer (PFA-100®) was compared regarding contact activa...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.689038
更新日期:2013-01-01 00:00:00
abstract::Previous studies have reported increased platelet activation and aggregation in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) treatment has been shown to decrease platelet activation. We aimed to study the effects of nasal CPAP therapy has on MPV values in patients with severe...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.578182
更新日期:2011-01-01 00:00:00
abstract::The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109976103
更新日期:1999-07-01 00:00:00
abstract::We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with thrombocytopenia. Following inefficient treatment of four platelet transfusions, immunoglobulins, and corticosteroids, we initiated treatment with a thrombopoietin (TPO)...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1246717
更新日期:2017-07-01 00:00:00
abstract::Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537104.2018.1528347
更新日期:2019-01-01 00:00:00
abstract::The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segments individual platelets to facilitate the analysis of large numbers...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1748588
更新日期:2021-01-02 00:00:00
abstract::A variety of flow cytometry techniques are in use to evaluate in vivo blood platelet activation. We have in this study further developed and optimised these methods to be suitable for use in clinical studies. By preloading the Monovette EDTA vacuum blood sampling tubes with 1/8 vol 4% (w/v) paraformaldehyde (PFA), we ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/095371000403071
更新日期:2000-05-01 00:00:00
abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1492105
更新日期:2018-12-01 00:00:00
abstract::The influence of three anti-platelet drugs, cilostazol, aspirin, and tirofiban, was investigated on platelet-leukocyte interaction by flow cytometry. When platelets and leukocytes were pre-incubated with anti-platelet drugs and stimulated by thrombin or collagen, cilostazol was found to inhibit platelet adhesion to mo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100410001715583
更新日期:2004-08-01 00:00:00
abstract::Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1499887
更新日期:2019-01-01 00:00:00
abstract::Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1665639
更新日期:2020-01-01 00:00:00
abstract::Prostaglandins stimulate cyclic AMP synthesis in platelets, leading to inhibition of platelet aggregation. Prostaglandin receptors have been identified but knowledge of their pharmacology is limited by the lack of antagonists. Kinetic measurements of prostaglandinregulated cyclic AMP formation provide useful informati...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109009009190
更新日期:1990-01-01 00:00:00
abstract::This phase III, randomized, placebo-controlled study conducted in three stages (6-week, randomized, placebo-controlled stage 1; 24-week, open-label stage 2; and continuous extension stage 3) assessed the long-term efficacy and safety of eltrombopag use in Chinese patients with chronic immune thrombocytopenia (ITP). Th...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1847267
更新日期:2020-11-29 00:00:00
abstract::The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802434861
更新日期:2009-02-01 00:00:00
abstract::Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1356451
更新日期:2018-11-01 00:00:00