Abstract:
:Platelet aggregation is usually measured by a spectroscopic method using an aggregometer. However, when the process of platelet aggregation is followed by the changes in light transmission of platelet-rich plasma (PRP), factors such as platelet deformation or changes in plasma permeability must be taken into consideration. Thus, a better method was developed in our laboratory for measuring platelet aggregation by chronologically counting non-aggregated single platelets, one of the simplest parameters of the aggregation process, using PRP to which adenosine diphosphate (ADP) was added.(1,2) In the present study, we attempted to further evaluate platelet aggregability by measuring the velocity of platelet aggregation in different subjects using our single platelet counting method.
journal_name
Plateletsjournal_title
Plateletsauthors
Suehiro A,Higashi T,Kakishita Edoi
10.3109/09537109209003395subject
Has Abstractpub_date
1992-01-01 00:00:00pages
95-6issue
2eissn
0953-7104issn
1369-1635journal_volume
3pub_type
杂志文章相关文献
PLATELETS文献大全abstract::The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platel...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1514107
更新日期:2019-01-01 00:00:00
abstract::Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.525722
更新日期:2011-01-01 00:00:00
abstract::Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2013.852660
更新日期:2014-01-01 00:00:00
abstract::Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced ser...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1378808
更新日期:2018-05-01 00:00:00
abstract::Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1031650
更新日期:2015-01-01 00:00:00
abstract::Blood platelets, in analogy to other circulating blood cells, can generate reactive oxygen/nitrogen species (ROS/RNS) that may behave as second messengers and may regulate platelet functions. Accumulating evidence suggest a role of ROS/RNS in platelet activation. On the other hand, an increased production of ROS/RNS c...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100701504087
更新日期:2007-12-01 00:00:00
abstract::Platelet shape change is an extremely rapid process mediated by both the calcium-sensitive and p160ROCK pathways. The present study examines how different features of shape change studied by scanning electron microscopy clearly correlate to changes in the pattern of light absorbance measured in an aggregometer. Platel...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953710031000092794
更新日期:2003-05-01 00:00:00
abstract::Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expr...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100500140190
更新日期:2005-09-01 00:00:00
abstract::The frequency distributions of HPA-1 to HPA-6 and HPA-15 were evaluated in two Brazilian populations from Parana: a mixed population of predominantly Caucasians and a population of Japanese descendants. Genotyping was performed by PCR-SSP in 364 unrelated individuals. Differences in the distribution of HPA highlight d...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1257785
更新日期:2017-09-01 00:00:00
abstract::Oxidative damage to lipids in plasma, blood platelets and neurons in patients with schizophrenia was described. The aim of our present study was to evaluate oxidative/nitrative modifications of blood platelets proteins by measurement the level of biomarkers of oxidative stress such as carbonyl groups, thiol groups and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802641499
更新日期:2009-03-01 00:00:00
abstract::In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1609668
更新日期:2020-01-01 00:00:00
abstract::To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were ...
journal_title:Platelets
pub_type: 杂志文章,多中心研究
doi:10.3109/09537104.2012.731111
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109409005529
更新日期:1994-01-01 00:00:00
abstract::Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1119814
更新日期:2016-07-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1742315
更新日期:2020-04-03 00:00:00
abstract::Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1573314
更新日期:2020-01-01 00:00:00
abstract::Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1732328
更新日期:2021-01-02 00:00:00
abstract::R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously admin...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1356450
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to determine whether autologous fresh platelet concentrate (PC) significantly improves haemostasis in cardiac reoperations compared with autologous fresh whole blood (WB). Forty-eight patients who had elective cardiac reoperations with a low-dose aprotinin priming regimen were divided into tw...
journal_title:Platelets
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/09537100120058801
更新日期:2001-06-01 00:00:00
abstract::A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953371027000
更新日期:2002-06-01 00:00:00
abstract::Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1499887
更新日期:2019-01-01 00:00:00
abstract::Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1032919
更新日期:2016-01-01 00:00:00
abstract::Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. Aronia melanocarpa fruits (Rosaceae) are one of the richest plant sources of phenolic substances shown to have anti-inflammatory, antitumor, antioxidative and antiplate...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537101003612821
更新日期:2010-01-01 00:00:00
abstract::Thrombocytopenia is one of the most frequent hematologic abnormalities in the neonatal period, affecting about 18-35% of all patients admitted to the Neonatal Intensive Care Unit (NICU), with sepsis being among the most common causes of severe neonatal thrombocytopenia. It is unclear whether decreased platelet product...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.696748
更新日期:2013-01-01 00:00:00
abstract::Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903215417
更新日期:2009-11-01 00:00:00
abstract::Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.642031
更新日期:2012-01-01 00:00:00
abstract::Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537104.2010.547959
更新日期:2011-01-01 00:00:00
abstract::Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2016.1265925
更新日期:2017-05-01 00:00:00
abstract::Photochemical treatment (PCT) of platelet concentrates, using amotosalen HCl and UVA-light, inactivates pathogens by forming adducts between amotosalen and nucleic acids. The impact of the photochemical treatment on pathogens and leukocytes has been studied extensively. Yet little is known about the effect of PCT on n...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500129300
更新日期:2005-12-01 00:00:00
abstract::Adrenaline is a platelet activator having a resting plasma concentration of <1 nmol/l that increases to a few nmol/l during stress. However, most in vitro assays only detect effects of adrenaline in micromolar concentrations. This makes it difficult to estimate the relevance of in vitro data for the in vivo situation....
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.672780
更新日期:2013-01-01 00:00:00