R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy.

abstract：:The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segments individual platelets to facilitate the analysis of large numbers...

journal_title：Platelets

authors： Pike JA,Simms VA,Smith CW,Morgan NV,Khan AO,Poulter NS,Styles IB,Thomas SG

更新日期：2021-01-02 00:00:00

abstract：:Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measu...

journal_title：Platelets

authors： García-Guerra R,Mateo CR,García-Muñoz MS,Zapata MA,Plaza I,González-Rodríguez J

更新日期：1998-01-01 00:00:00

abstract：:This study investigated the mechanism by which treatment of the CHRF 288-11 megakaryoblastic cell line with phorbol myristate acetate caused a transient increase in adhesion. The adhesion to tissue culture plastic occurred within 4 h and could be reversed by treatment with RGDS-peptide suggesting the involvement of on...

journal_title：Platelets

authors： Conran N,Hemming FW

更新日期：1999-01-01 00:00:00

abstract：:Blood platelets, in analogy to other circulating blood cells, can generate reactive oxygen/nitrogen species (ROS/RNS) that may behave as second messengers and may regulate platelet functions. Accumulating evidence suggest a role of ROS/RNS in platelet activation. On the other hand, an increased production of ROS/RNS c...

journal_title：Platelets

authors： Olas B,Wachowicz B

更新日期：2007-12-01 00:00:00

abstract：:The aim of the present retrospective observational study was to evaluate the time of functional recovery following a specific combined therapeutic approach characterized by an active exercise therapy carried out immediately after Platelet-rich plasma (PRP) injections for the treatment of the muscular lesion of the dis...

journal_title：Platelets

authors： Borrione P,Fossati C,Pereira MT,Giannini S,Davico M,Minganti C,Pigozzi F

更新日期：2018-09-01 00:00:00

abstract：:In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from seco...

journal_title：Platelets

authors： Rejtö L,Schlammadinger A,László P,Kiss A,Telek B,Boda Z

更新日期：2000-02-01 00:00:00

abstract：:In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...

journal_title：Platelets

authors： Meyer M,Thieme A,Jablonka B,Just M,Ströhl C,Schellenberg I,Kirchmaier CM

更新日期：1996-01-01 00:00:00

abstract：:The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...

journal_title：Platelets

authors： Moseley GW

更新日期：2005-02-01 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:In this study, we have examined whether the platelet Fc-receptor, FcγRII (CD32), is associated with either of the two major platelet membrane glycoproteins, the GPIb-IX complex and the GPIIb-IIIa complex. Monoclonal and polyclonal anti-GPIb-IX complex antibodies inhibited to only a moderate degree (< 40%) the binding ...

journal_title：Platelets

authors： Berndt MC,Mazurov AV,Vinogradov DV,Burns GF,Chesterman CN

更新日期：1993-01-01 00:00:00

abstract：:No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

journal_title：Platelets

authors： Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

更新日期：2010-01-01 00:00:00

abstract：:Mechanisms involved in the reduction of blood platelet functions by various plant extract, including the grape seeds extract (rich in phenolic compounds, a mixture of about 95% oligomeric phenols; GSE) are still unclear. In the literature there are few papers describing studies on the effects of GSE on selected elemen...

journal_title：Platelets

authors： Olas B,Wachowicz B,Stochmal A,Oleszek W

更新日期：2012-01-01 00:00:00

abstract：:Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

journal_title：Platelets

authors： Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

更新日期：2009-05-01 00:00:00

abstract：:Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or ...

journal_title：Platelets

authors： Toya T,Yoshimi A,Morioka T,Arai S,Ichikawa M,Usuki K,Kurokawa M

更新日期：2014-01-01 00:00:00

abstract：:SIRT1, a class III histone deacetylase, is critically involved in cellular response to stress and modulates cardiovascular risk factors. However, its role in thrombus formation is largely unknown. Thus, this study investigated the effect of SIRT1 on pulmonary thrombus formation, and then identified its role in the mod...

journal_title：Platelets

authors： Kim YH,Bae JU,Kim IS,Chang CL,Oh SO,Kim CD

更新日期：2016-12-01 00:00:00

abstract：:Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. Aronia melanocarpa fruits (Rosaceae) are one of the richest plant sources of phenolic substances shown to have anti-inflammatory, antitumor, antioxidative and antiplate...

journal_title：Platelets

authors： Olas B,Kedzierska M,Wachowicz B,Stochmal A,Oleszek W

更新日期：2010-01-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...

journal_title：Platelets

authors： Unterberger U,Eichelberger B,Ulz A,Panzer S

更新日期：2017-06-01 00:00:00

abstract：:Type 2B von Willebrand's disease (VWD) is an inherited bleeding disorder characterized by spontaneous binding of large von Willebrand factor (VWF) multimers to platelets in vivo. This phenomenon induces the clearance of both large multimers and platelets, usually resulting in thrombocytopenia with slightly increased p...

journal_title：Platelets

authors： Loffredo G,Baronciani L,Noris P,Menna F,Federici AB,Balduini CL

更新日期：2006-05-01 00:00:00

abstract：:A hypercoagulable state has, in observational studies, been associated with increased risk of thromboembolic events. The aim of this trial was to study whether dual antiplatelet therapy (DAPT) with clopidogrel in addition to aspirin could reduce the rate of graft occlusions, thromboembolic events, and death compared t...

journal_title：Platelets

authors： Rafiq S,Johansson PI,Kofoed KF,Lund JT,Olsen PS,Bentsen S,Steinbrüchel DA

更新日期：2017-12-01 00:00:00

abstract：:Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation, whereas GPIbα decreases due to ectodomain shedding. As an important...

journal_title：Platelets

authors： Hosseini E,Ghasemzadeh M,Nassaji F,Jamaat ZP

更新日期：2017-07-01 00:00:00

abstract：:Hemorrhage is a significant pathological feature of some fever or hyperthermia-related diseases, such as dengue fever and heatstroke. Although the mechanisms of hemorrhage in these diseases are thought to be complex, whether there is an association between hemorrhage and hyperthermia or fever remains unclear. Platelet...

journal_title：Platelets

authors： Wang Z,Shi Q,Li S,Du J,Liu J,Dai K

更新日期：2010-01-01 00:00:00

abstract：:Platelets are involved in host defense via clearance of bacteria from the circulation, interaction with virus particles, and uptake of various size particulates. There is a growing interest in micro- and nanoparticles for drug delivery and there is evidence that the properties of these particles critically influence t...

journal_title：Platelets

authors： Gupalo E,Kuk C,Qadura M,Buriachkovskaia L,Othman M

更新日期：2013-01-01 00:00:00

abstract：:The generation of superoxide anion radicals (O2*-) and the other reactive oxygen species (ROS) was estimated by means of cytochrome c reduction and chemiluminescence, as well in resting blood platelets and in platelets stimulated by thrombin in the presence or absence of some inhibitors of pathways involved in platele...

journal_title：Platelets

authors： Wachowicz B,Olas B,Zbikowska HM,Buczyński A

更新日期：2002-05-01 00:00:00

abstract：:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were...

journal_title：Platelets

authors： Zhao P,Hou M,Liu Y,Liu HX,Huang RB,Yao HX,Niu T,Peng J,Jiang M,Han YQ,Hu JD,Zhou H,Zhou ZP,Qiu L,Zhang LS,Wang X,Wang HQ,Feng R,Yang LH,Ma LM,Wang SQ,Kong PY,Wang WS,Sun HP,Sun J,Zhou HB,Zhu TN,Wang

更新日期：2020-07-02 00:00:00

abstract：:Combined inhibition of platelet aggregation is essential to prevent recurrent ischemic episodes in patients with acute coronary syndromes and after percutaneous coronary interventions (PCIs). In combination with aspirin, the ADP receptor antagonist clopidogrel is used widespread for this purpose; however, platelet rea...

journal_title：Platelets

authors： Aradi D,Komócsi A

更新日期：2012-01-01 00:00:00

abstract：:Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...

journal_title：Platelets

authors： Ngo ATP,Sheriff J,Rocheleau AD,Bucher M,Jones KR,Sepp AI,Malone LE,Zigomalas A,Maloyan A,Bahou WF,Bluestein D,McCarty OJT,Haley KM

更新日期：2020-01-01 00:00:00

abstract：:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

journal_title：Platelets

authors： Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

更新日期：2004-02-01 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00

abstract：:On activation platelets release microRNAs and extracellular vesicles (EV) into circulation. The release of EV from platelets has been shown to be dependent on the agonist; in this study, we investigated whether the microRNA profile or EV released from platelets was also agonist specific. Washed platelets from healthy ...

journal_title：Platelets

authors： Ambrose AR,Alsahli MA,Kurmani SA,Goodall AH

更新日期：2018-07-01 00:00:00