Abstract:
:The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, as well as on thrombininduced platelet aggregation and malonyldialdehyde (MDA) production in vitro. Pretreatment of platelets with resveratrol (50 microg/ml) inhibited their adhesion to collagen (by 32% in resting platelets and by 57% in thrombin-activated platelets after 1 h of preincubation) and thrombin-induced platelet aggregation (by 59% after 30 min preincubation). Resveratrol also had an inhibitory effect on the generation of malonyldialdehyde (a marker of thromboxane A(2) synthesis) measured as thiobarbituric reactive substance in thrombin-activated platelets.
journal_name
Plateletsjournal_title
Plateletsauthors
Zbikowska HM,Olas B,Wachowicz B,Krajewski Tdoi
10.1080/09537109976103subject
Has Abstractpub_date
1999-07-01 00:00:00pages
247-52issue
4eissn
0953-7104issn
1369-1635pii
WBLGYQPGUAK3EX47journal_volume
10pub_type
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