Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis.

abstract：:FVIII is an important cofactor in the tenase coagulation factor complex, lack of FVIII causes severe bleeding, whereas high FVIII levels seem to be associated with venous and arterial thromboembolism. Resting platelets do not bind FVIII, but activated platelets bind unactivated FVIII if vWF is not present. We investig...

journal_title：Platelets

authors： Obergfell A,Sturm A,Speer CP,Walter U,Grossmann R

更新日期：2006-11-01 00:00:00

abstract：:In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...

journal_title：Platelets

authors： Wang C,Zheng W,Shaqdan A,Wang C,Qin X,Zhao X,Wang X,Yuan L,Nie S,Liu R

更新日期：2020-01-01 00:00:00

abstract：:Recent studies suggest that anti-platelet agents are not equally effective in all individuals. We have developed a new method to evaluate the effect of anti-platelet drugs using the cone and plate(let) analyzer (CPA) test. The method is based on the ability of activators to reduce platelet adhesion under flow conditio...

journal_title：Platelets

authors： Spectre G,Brill A,Gural A,Shenkman B,Touretsky N,Mosseri E,Savion N,Varon D

更新日期：2005-08-01 00:00:00

abstract：:Measurement of platelet aggregation in platelet-rich plasma (PRP) is a fundamental tool in platelet studies, despite the fact that the technique required for this is time-consuming, may need large volumes of blood, and require particular skill and special equipment. The use of a microplate reader seems useful to perfo...

journal_title：Platelets

authors： Krause S,Scholz T,Temmler U,Lösche W

更新日期：2001-11-01 00:00:00

abstract：:Peroxynitrite is a potent nitrating and oxidizing agent that exerts differential effects on platelets. In the present study we investigated the influence of peroxynitrite on vasodilator-stimulated phosphoprotein (VASP), a protein that plays a key role in inhibition of platelet adhesion and spreading. In platelets, VAS...

journal_title：Platelets

authors： Aburima A,Riba R,Naseem KM

更新日期：2010-01-01 00:00:00

abstract：:It has been suggested that thromboelastography TEG) can help in limiting or directing the appropriate use of blood products during surgery. However, the contribution of platelets to the TEG profile has not been studied in detail. Blood was taken from eight healthy subjects and eight patients with peripheral arterial d...

journal_title：Platelets

authors： Bowbrick VA,Mikhailidis DP,Stansby G

更新日期：2003-06-01 00:00:00

abstract：:A controversial discussion as to whether human platelets are capable of regulated protein synthesis has been ongoing for over half a century. A previous study has suggested that human platelets synthesize large amounts of interleukin 1beta (IL-1beta) in response to external cues and in a physiologically significant ma...

journal_title：Platelets

authors： Pillitteri D,Bassus S,Boller K,Mahnel R,Scholz T,Westrup D,Wegert W,Kirchmaier CM

更新日期：2007-03-01 00:00:00

abstract：:The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were t...

journal_title：Platelets

authors： Mazurov AV,Pevzner DV,Antonova OA,Byzova TV,Khaspekova SG,Semenov AV,Vlasik TN,Samko AN,Staroverov II,Ruda MY

更新日期：2002-12-01 00:00:00

abstract：:In the presence of large bone defects, delayed bone union, or nonunion and fractures, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates (APCs). Due to the high content of platelets and platelet-derived bioactive...

journal_title：Platelets

authors： Marcazzan S,Taschieri S,Weinstein RL,Del Fabbro M

更新日期：2018-06-01 00:00:00

abstract：:The present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 wo...

journal_title：Platelets

authors： Yazici S,Yazici M,Erer B,Erer B,Calik Y,Ozhan H,Ataoglu S

更新日期：2010-01-01 00:00:00

abstract：:We previously reported that thrombin-induced Ca(2+) mobilization was enhanced in aged rat platelets. Since Ca(2+) mobilization in platelets is believed to be closely associated with platelet activation, we examined Ca(2+) mobilization and the aggregatory response to ADP and thrombin in young (3 months) and aged (24 mo...

journal_title：Platelets

authors： Sugidachi A,Asai F,Oshima T,Koike H

更新日期：1995-01-01 00:00:00

abstract：:The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise...

journal_title：Platelets

authors： Salim JP,Glembotsky AC,Lev PR,Marin Oyarzún CP,Goette NP,Molinas FC,Marta RF,Heller PG

更新日期：2017-09-01 00:00:00

abstract：:The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...

journal_title：Platelets

authors： White JG,Kumar A,Hogan MJ

更新日期：2006-12-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive ...

journal_title：Platelets

authors： Chen S,Hu M,Shen M,Xu Y,Wang C,Wang X,Li F,Zeng D,Chen F,Zhao G,Chen M,Wang F,Cheng T,Su Y,Zhao J,Wang S,Wang J

更新日期：2018-11-01 00:00:00

abstract：:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...

journal_title：Platelets

authors： Coban E,Kucuktag S,Basyigit S

更新日期：2007-12-01 00:00:00

abstract：:The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...

journal_title：Platelets

authors： Li J,Li Y,Ouyang J,Zhang F,Liang C,Ye Z,Chen S,Cheng J

更新日期：2020-08-17 00:00:00

abstract：:The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth muscle cell (ASMC) proliferation. Co-incubation of platelets and ASMC caused platelet activation as determined by morphological changes. Simultaneously, reactive oxygen species (ROS)-generation was de...

journal_title：Platelets

authors： Svensson Holm AC,Grenegård M,Ollinger K,Lindström EG

更新日期：2014-01-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...

journal_title：Platelets

authors： Pennings GJ,Yong AS,Wong C,Al-Tamimi M,Gardiner EE,Andrews RK,Kritharides L

更新日期：2014-01-01 00:00:00

abstract：:The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platel...

journal_title：Platelets

authors： Unsworth AJ,Bye AP,Kriek N,Sage T,Osborne AA,Donaghy D,Gibbins JM

更新日期：2019-01-01 00:00:00

abstract：:Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...

journal_title：Platelets

authors： Jung SM,Sonoda M,Tsuji K,Jimi A,Nomura S,Kanaji T,Moroi M

更新日期：2010-01-01 00:00:00

abstract：:The inhibitory effects of a cyclooxygenase inhibitor, indomethacin, and a thromboxane (TX) A(2) receptor antagonist, S-145, on thrombin-stimulated rabbit platelet responses were examined for their contribution to the TXA-mediated amplification mechanism. Although thrombin (0.01-0.3 U/ml) induced the dosedependent aggr...

journal_title：Platelets

authors： Kawamura M,Huang A,Harada Y,Katori M

更新日期：1994-01-01 00:00:00

abstract：:Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which is in line with a morning enhancement of platelet aggregation. We investigated whether platelet inhibition during clopidogrel and aspirin therapy varies during the day. Fifty-nine consecu...

journal_title：Platelets

authors： Kozinski M,Bielis L,Wisniewska-Szmyt J,Boinska J,Stolarek W,Marciniak A,Kubica A,Grabczewska Z,Navarese EP,Andreotti F,Siller-Matula JM,Rosc D,Kubica J

更新日期：2011-01-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00

abstract：:No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

journal_title：Platelets

authors： Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

更新日期：2010-01-01 00:00:00

abstract：:Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...

journal_title：Platelets

authors： Gende OA

更新日期：2005-11-01 00:00:00

abstract：:Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), perf...

journal_title：Platelets

authors： Tanous O,Steinberg Shemer O,Yacobovich J,Zoldan M,Horovitz Y,Yaniv I,Rabizadeh E,Tamary H,Nakav S,Lahav J

更新日期：2017-11-01 00:00:00

abstract：:The action of sodium nitroprusside, an activator of guanylate cyclase, on rabbit platelets stimulated with PAF-acether, was studied singly or in combination with verapamil. Not only did sodium nitroprusside in the range 10(-6) to 10(-4) M inhibit PAF-acether induced aggregation, but it also brought about desaggregatio...

journal_title：Platelets

authors： Khan SN,Smith AD,Neal CR,Pittilo RM

更新日期：1993-01-01 00:00:00

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00