Thrombopoietin-receptor agonists in haematological disorders: the Danish experience.

Abstract:

:The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 2009 to 1 May 2011 were available for data collection and included in the study. Of these patients, 15 received TPO-ra for refractory primary ITP, 7 for secondary ITP (chronic lymphatic leukaemia, systemic lupus erythematosus, Evans syndrome, human immunodeficiency virus and celiac disease) and 10 were treated for non-ITP (chemotherapy-induced, acute myeloid leukaemia, myelodysplastic syndrome, hereditary spherocytosis and suspected chemically induced thrombocytopenia). Initial response to TPO-ra defined as platelet counts >30 × 10(9)/l after 4 weeks of treatment was found in 59% of primary ITP patients, 57% of patients with secondary ITP and 40% of patients with non-ITP. There were four deaths in the cohort, three of which were related to pre-existing medical conditions. Otherwise adverse effects were in general mild. This Danish retrospective registration study has demonstrated that in the off-protocol setting, the use of TPO-ra is associated with response rates largely similar to those seen in previous protocol-monitored studies and no new adverse events were reported.

journal_name

Platelets

journal_title

Platelets

authors

Gudbrandsdottir S,Frederiksen H,Hasselbalch H

doi

10.3109/09537104.2011.634931

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

423-9

issue

6

eissn

0953-7104

issn

1369-1635

journal_volume

23

pub_type

杂志文章
  • The role of platelet activation in determining response to therapy in patients with primary nephrotic syndrome.

    abstract::To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were ...

    journal_title:Platelets

    pub_type: 杂志文章,多中心研究

    doi:10.3109/09537104.2012.731111

    authors: Kocyigit I,Yilmaz MI,Simşek Y,Unal A,Sipahioglu MH,Eroglu E,Dede F,Tokgoz B,Oymak O,Utas C

    更新日期:2013-01-01 00:00:00

  • Measuring soluble platelet glycoprotein VI in human plasma by ELISA.

    abstract::Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100802710286

    authors: Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

    更新日期:2009-05-01 00:00:00

  • Evaluating platelet function disorders in children with bleeding tendency - A single center study.

    abstract::Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), perf...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1257784

    authors: Tanous O,Steinberg Shemer O,Yacobovich J,Zoldan M,Horovitz Y,Yaniv I,Rabizadeh E,Tamary H,Nakav S,Lahav J

    更新日期:2017-11-01 00:00:00

  • Aspirin, platelet inhibition and cancer prevention.

    abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2018.1492105

    authors: Patrignani P,Patrono C

    更新日期:2018-12-01 00:00:00

  • New insights into thrombopoiesis in neonatal sepsis.

    abstract::Thrombocytopenia is one of the most frequent hematologic abnormalities in the neonatal period, affecting about 18-35% of all patients admitted to the Neonatal Intensive Care Unit (NICU), with sepsis being among the most common causes of severe neonatal thrombocytopenia. It is unclear whether decreased platelet product...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2012.696748

    authors: Eissa DS,El-Farrash RA

    更新日期:2013-01-01 00:00:00

  • Influence of a single dose of calcium channel blockers on platelet function.

    abstract::Calcium channel blockers are known to inhibit platelet aggregation in vitro and ex vivo. We studied the influence of a single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg) on ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109109005501

    authors: Weiss K,Fitscha P,Virgolini I,O'grady J,Sinzinger H

    更新日期:1991-01-01 00:00:00

  • Development of a high-yield expression and purification system for platelet factor 4.

    abstract::Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced ser...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2017.1378808

    authors: Huynh A,Arnold DM,Moore JC,Smith JW,Kelton JG,Nazy I

    更新日期:2018-05-01 00:00:00

  • Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage.

    abstract::We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with thrombocytopenia. Following inefficient treatment of four platelet transfusions, immunoglobulins, and corticosteroids, we initiated treatment with a thrombopoietin (TPO)...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1246717

    authors: Espitia O,Ternisien C,Agard C,Boisseau P,Denis CV,Fouassier M

    更新日期:2017-07-01 00:00:00

  • Predicting metabolic syndrome by using hematogram models in elderly women.

    abstract:BACKGROUND:Low-grade inflammatory status was thought to be a major underlying mechanism in MetS. White blood cell (WBC) count was one of the inflammatory markers identified to be associated with MetS. Moreover, not only WBC but also hemoglobin (Hb) and platelet (PLT) were all associated with MetS. OBJECTIVE:In this st...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2013.780017

    authors: Liu H,Hsu CH,Lin JD,Hsieh CH,Lian WC,Wu CZ,Pei D,Chen YL

    更新日期:2014-01-01 00:00:00

  • The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia.

    abstract::Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.642031

    authors: Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

    更新日期:2012-01-01 00:00:00

  • Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke.

    abstract::Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100310001644024

    authors: Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

    更新日期:2004-02-01 00:00:00

  • Platelet count and mortality of H7N9 infected patients in Guangdong, China.

    abstract::Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2019.1665639

    authors: Chen Y,Yang Y,Cheng J,Lu J,Hu W

    更新日期:2020-01-01 00:00:00

  • Brachial artery endothelial function predicts platelet function in control subjects and in patients with acute myocardial infarction.

    abstract::Platelet activation occurs in an endothelium-dependent flow-mediated dilation (FMD) impairment environment. The aim of this study was to explore the association between platelet reactivity and brachial artery FMD in individuals without established cardiovascular disease (controls) and acute myocardial infarction (AMI)...

    journal_title:Platelets

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/09537104.2011.604805

    authors: Shechter M,Shechter A,Hod H,Fefer P,Shenkman B,Koren-Morag N,Feinberg MS,Harats D,Ami Sela B,Savion N,Varon D,Matetzky S

    更新日期:2012-01-01 00:00:00

  • Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders.

    abstract::Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2018.1445839

    authors: Bath PM,May J,Heptinstall S

    更新日期:2018-07-01 00:00:00

  • Ginkgo biloba extract EGb761 protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of SAMP8 mice.

    abstract::Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537100903511448

    authors: Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

    更新日期:2010-01-01 00:00:00

  • The expression of IFN-gamma, IL-4, Foxp3 and perforin genes are not correlated with DNA methylation status in patients with immune thrombocytopenic purpura.

    abstract::We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. Th...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537100903420277

    authors: Zhao H,Du W,Wang D,Gu D,Xue F,Ge J,Sui T,Yang R

    更新日期:2010-01-01 00:00:00

  • Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia.

    abstract::In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1235686

    authors: Unterberger U,Eichelberger B,Ulz A,Panzer S

    更新日期:2017-06-01 00:00:00

  • Cilostazol inhibits platelet-leukocyte interaction by suppression of platelet activation.

    abstract::The influence of three anti-platelet drugs, cilostazol, aspirin, and tirofiban, was investigated on platelet-leukocyte interaction by flow cytometry. When platelets and leukocytes were pre-incubated with anti-platelet drugs and stimulated by thrombin or collagen, cilostazol was found to inhibit platelet adhesion to mo...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100410001715583

    authors: Ito H,Miyakoda G,Mori T

    更新日期:2004-08-01 00:00:00

  • Selenium compounds inhibit the biological activity of blood platelets.

    abstract::The action of inorganic forms of selenium (Se) on blood platelet aggregation, secretion and the arachidonate pathway in vitro was studied. It was shown that sodium selenite, after 30 min preincubation, inhibited platelet aggregation induced by 0.1 U/ml of thrombin and by 10 microM ADP (about 30% inhibition of aggregat...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109976275

    authors: Zbikowska HM,Wachowicz B,Krajewski T

    更新日期:1999-01-01 00:00:00

  • Novel mutations in GP IIb gene in Glanzmann's thrombasthenia from India.

    abstract::The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100802434861

    authors: Vijapurkar M,Ghosh K,Shetty S

    更新日期:2009-02-01 00:00:00

  • The placenta: a site of platelet production?

    abstract::Stripping of cytoplasm from circulating megakaryocytes (MKs) in the pulmonary capillary bed implicates the lungs as an important site for platelet production in normal physiology. The placenta has been proposed as an alternative location for intrauterine platelet production as fetal lungs are essentially non-functioni...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109209013185

    authors: Woods MJ,Landon CR,Greaves M,Trowbridge EA

    更新日期:1992-01-01 00:00:00

  • Simultaneous genotyping of HPA-17w to -21w by PCR-SSP in Chinese Cantonese.

    abstract::Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2014.887668

    authors: Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

    更新日期:2015-01-01 00:00:00

  • Polysaccharide part of Proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen.

    abstract::Lipopolysaccharide (LPS, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. The action of LPS is related to the activation of many types of cells, including blood platelets. We examined the effects of different LPSs from Proteus mirabilis (smooth form LPS S1959 and r...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/0953710021000024385

    authors: Zielinski T,Wachowicz B,Saluk-Juszczak J,Kaca W

    更新日期:2002-11-01 00:00:00

  • Thrombocytopenia and GBA gene mutation in a patient with adult type 1 Gaucher disease.

    abstract::A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...

    journal_title:Platelets

    pub_type: 信件

    doi:10.1080/09537104.2017.1306044

    authors: Wan L,Wu H,Xie F,Nie Y

    更新日期:2017-12-01 00:00:00

  • Formation of PGD(2) Contributes to the Anti-aggregatory Efficacy of ZD1542, a Thromboxane A(2) Synthase Inhibitor and TP Receptor Antagonist, in Human Whole Blood.

    abstract::The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109409005529

    authors: Menys VC

    更新日期:1994-01-01 00:00:00

  • Platelet activation at the onset of human endotoxemia is undetectable in vivo.

    abstract::Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2015.1119814

    authors: Schrottmaier WC,Kral JB,Zeitlinger M,Salzmann M,Jilma B,Assinger A

    更新日期:2016-07-01 00:00:00

  • Frozen extracellular matrix preserves its thrombogenicity after thawing, while Matrigel induces a poor platelet response.

    abstract::Two putative substitutes for fresh endothelial cell (EC) extracellular matrix (ECM), frozen ECM and Matrigel, were studied using a parallel-plate perfusion system and platelet deposition was evaluated morphometrically. Coverslips covered with ECM were stored frozen at-30 C for 0 (fresh ECM), 1, 2, 3 or 4 weeks. The ab...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109876500

    authors: Bozzo J,Gómez-Ortiz G,Hernández MR,Garrido M,Ordinas A,Escolar G,Díaz-Ricart M

    更新日期:1998-01-01 00:00:00

  • The association between non-alcoholic hepatic steatosis and mean platelet volume in an obese Korean population.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease. Since the prevalence of NAFLD in overweight/obese people is rather high, there is a general concern about the possibility that NAFLD may have an association with cardiovascular risk factors and atherosclerosis. Mean platelet volume (MPV) i...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2010.540049

    authors: Shin WY,Jung DH,Shim JY,Lee HR

    更新日期:2011-01-01 00:00:00

  • Profile of reticulated platelets in the early, subacute and late phases after transient ischemic attack or ischemic stroke.

    abstract::Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2020.1850670

    authors: Lim ST,Tobin WO,Murphy S,Kinsella JA,Smith DR,Lim SY,Murphy SM,Coughlan T,Collins DR,O'Neill D,Egan B,Tierney S,McCabe D

    更新日期:2020-12-21 00:00:00

  • Ticlopidine does not reduce in vivo platelet thromboxane biosynthesis and metabolism in diabetic patients.

    abstract::Diabetic patients are at higher risk of development of cardiovascular complications than the general population. The role of platelets in the pathogenesis of these complications is still controversial, it being difficult to ascertain whether altered platelet function is a cause or consequence of vascular complications...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109309013203

    authors: Rotondo S,Cerletti C,Gaetano G,Tascione E

    更新日期:1993-01-01 00:00:00