Abstract:
:The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web). A proximal localisation/association of tetraspanins with Fc receptors (FcR) has been implied by the repeated rediscoveries of tetraspanins as the targets of antibodies which activate platelets and other blood cells through co-ligation of FcR. Direct evidence of tetraspanin-FcR interactions has come from immunoprecipitation and co-immunofluorescence studies. The functional effects of this interaction remain unclear, but tetraspanins have been identified as negative regulators of FcR signalling independently of co-ligation, indicating potential roles in modulating FcR function in co-ordination with the activity of other signalling/adhesion molecules in the tetraspanin web. Given their capacity to influence FcR signalling, tetraspanins could provide specific therapeutic targets for immune disorders including rheumatoid arthritis, asthma and allergies.
journal_name
Plateletsjournal_title
Plateletsauthors
Moseley GWdoi
10.1080/09537100400004363subject
Has Abstractpub_date
2005-02-01 00:00:00pages
3-12issue
1eissn
0953-7104issn
1369-1635pii
GUKHC1VA638TVRLVjournal_volume
16pub_type
杂志文章,评审相关文献
PLATELETS文献大全abstract::It has recently been demonstrated that both initiators and inhibitors (viz iloprost) of aggregation stimulate the uptake of [(45)Ca(2+)] by human platelets. Since it was postulated that this calcium uptake reflects changes associated with signal transduction, we investigated the role of cAMP-dependent protein kinases ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109309013234
更新日期:1993-01-01 00:00:00
abstract::The aim of this survey was to describe drug-induced immune thrombocytopenia (ITP) reported in the French PharmacoVigilance database (FPVD) and to discuss the drugs involved. The request to the FPVD used the seven most accurate diagnosis codes to identify ITP. The study was restricted to cases reported from 2007 to 201...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.633179
更新日期:2012-01-01 00:00:00
abstract::Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2014.887668
更新日期:2015-01-01 00:00:00
abstract::Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Diso...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802010547
更新日期:2008-08-01 00:00:00
abstract::The distribution of some proteoglycan anionic sites and carbohydrate moieties on the diabetic platelet surface has been investigated by cytochemical methods. Human blood platelets obtained from either diabetic patients (serum glycaemia 9.6-19.2 mmol/L) or normal donors were labeled with specific stains (Ruthenium Red,...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109409006047
更新日期:1994-01-01 00:00:00
abstract::Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600757695
更新日期:2006-09-01 00:00:00
abstract::Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1850670
更新日期:2020-12-21 00:00:00
abstract::The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/02697450310001632597
更新日期:2003-11-01 00:00:00
abstract::Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expr...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100500140190
更新日期:2005-09-01 00:00:00
abstract::The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth muscle cell (ASMC) proliferation. Co-incubation of platelets and ASMC caused platelet activation as determined by morphological changes. Simultaneously, reactive oxygen species (ROS)-generation was de...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2013.783688
更新日期:2014-01-01 00:00:00
abstract::Adenosine diphosphate (ADP) is recognized as an important mediator of platelet aggregation. Transient aggregation at low (< or =1 microM), and sustained aggregation at higher ADP concentrations are consistently observed. Dissociation of platelet aggregates has been described and may explain the reversible component of...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100120071004
更新日期:2001-08-01 00:00:00
abstract::Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which is in line with a morning enhancement of platelet aggregation. We investigated whether platelet inhibition during clopidogrel and aspirin therapy varies during the day. Fifty-nine consecu...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.582900
更新日期:2011-01-01 00:00:00
abstract::Diabetic patients are at higher risk of development of cardiovascular complications than the general population. The role of platelets in the pathogenesis of these complications is still controversial, it being difficult to ascertain whether altered platelet function is a cause or consequence of vascular complications...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109309013203
更新日期:1993-01-01 00:00:00
abstract::Thrombocytopenia is common in the neonatal intensive care unit. Transfusion of platelets is often required. The purpose of our study was to determine changes in thrombopoietin (Tpo) following transfusion of platelets in preterm neonates. Preterm neonates undergoing platelet transfusion were randomized to receive a tra...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537100802220476
更新日期:2008-09-01 00:00:00
abstract::A number of hematopoietic growth factors and other cytokines are capable of altering platelet production and function. Enhancement of these processes may be exploited to ameliorate bleeding propensity in thrombocytopenic patients. Under certain circumstances, cytokines may have adverse effects on the hemostatic system...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109709169324
更新日期:1997-01-01 00:00:00
abstract::Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1478400
更新日期:2019-01-01 00:00:00
abstract::Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional labor...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903377584
更新日期:2010-01-01 00:00:00
abstract::Blood platelets, in analogy to other circulating blood cells, can generate reactive oxygen/nitrogen species (ROS/RNS) that may behave as second messengers and may regulate platelet functions. Accumulating evidence suggest a role of ROS/RNS in platelet activation. On the other hand, an increased production of ROS/RNS c...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100701504087
更新日期:2007-12-01 00:00:00
abstract::Erythropoietin (EPO) enhances formation of red blood cells and also affects thrombopoiesis and platelet function. We hypothesized that the effect of EPO may be reflected by changes in thromboxane B2 (TXB2) and endothelial cell function. Six male and six female subjects received recombinant human epoetin alpha (Erypo®)...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.631621
更新日期:2012-01-01 00:00:00
abstract::D-glucono-1,4-lactone, sodium D-gluconate and calcium D-glucarate are non-toxic glucose derivatives occurring naturally in fruits and vegetables. Calcium D-glucarate is promoted as an orally bioavailability dietary supplement with potential chemopreventive activity without adverse effects. Despite many commercial appl...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.512210
更新日期:2010-01-01 00:00:00
abstract::Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903511448
更新日期:2010-01-01 00:00:00
abstract::In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1235686
更新日期:2017-06-01 00:00:00
abstract::Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2017.1319047
更新日期:2017-07-01 00:00:00
abstract::In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1609668
更新日期:2020-01-01 00:00:00
abstract::Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or '...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109609023587
更新日期:1996-01-01 00:00:00
abstract::To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were ...
journal_title:Platelets
pub_type: 杂志文章,多中心研究
doi:10.3109/09537104.2012.731111
更新日期:2013-01-01 00:00:00
abstract::In previous studies we have shown that relaxin (RLX), a peptide hormone produced predominantly during pregnancy, is a powerful inhibitor of platelet aggregation. The current study shows that RLX, given systemically to rats, also affects the number of circulating platelets and their release by spleen megakaryocytes. Ma...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109509078467
更新日期:1995-01-01 00:00:00
abstract::Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1780205
更新日期:2020-11-16 00:00:00
abstract::Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.724484
更新日期:2013-01-01 00:00:00
abstract::We previously reported that thrombin-induced Ca(2+) mobilization was enhanced in aged rat platelets. Since Ca(2+) mobilization in platelets is believed to be closely associated with platelet activation, we examined Ca(2+) mobilization and the aggregatory response to ADP and thrombin in young (3 months) and aged (24 mo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109509078477
更新日期:1995-01-01 00:00:00