Abstract:
:The main purpose of the present investigation was to study the effect of cloturin on aerobic glycolysis, endogenous and exogenous respiration and the level of ATP in both Ehrlich ascites carcinoma (EAC) and P388 murine leukaemia cells incubated in vitro. Also its effect on the level of total (T-SH) and non-protein (NP-SH) thiol groups was investigated. A significant inhibition of aerobic glycolysis was found only in P388 cells after 60 min of cloturin action. Cloturin inhibited both endogenous and exogenous respiration of EAC with succinate as substrate. Cloturin decreased the level of ATP after 2 h incubation in both types of tumour cell. The level of NP-SH was decreased more than that of T-SH in both types of cell.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Miko M,Krepelka J,Melka Mdoi
10.1002/cbf.290100208subject
Has Abstractpub_date
1992-06-01 00:00:00pages
115-22issue
2eissn
0263-6484issn
1099-0844journal_volume
10pub_type
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