Cloturin: effect on energy-producing processes in Ehrlich ascites and P388 murine leukaemia cells.

Abstract:

:The main purpose of the present investigation was to study the effect of cloturin on aerobic glycolysis, endogenous and exogenous respiration and the level of ATP in both Ehrlich ascites carcinoma (EAC) and P388 murine leukaemia cells incubated in vitro. Also its effect on the level of total (T-SH) and non-protein (NP-SH) thiol groups was investigated. A significant inhibition of aerobic glycolysis was found only in P388 cells after 60 min of cloturin action. Cloturin inhibited both endogenous and exogenous respiration of EAC with succinate as substrate. Cloturin decreased the level of ATP after 2 h incubation in both types of tumour cell. The level of NP-SH was decreased more than that of T-SH in both types of cell.

journal_name

Cell Biochem Funct

authors

Miko M,Krepelka J,Melka M

doi

10.1002/cbf.290100208

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

115-22

issue

2

eissn

0263-6484

issn

1099-0844

journal_volume

10

pub_type

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