Abstract:
:Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF-beta is a pluripotent cytokine in a wide range of cell types. In particular it has been found to be a potent inducer of ECM protein synthesis and fibroblast migration. The TGF-beta1 gene is highly polymorphic and two signal sequence polymorphisms at codon 10 and codon 25 are linked to disease outcomes. In this study, we analysed two polymorphic sites of the TGF-beta1 gene, codon 10 and codon 25, in 43 Turkish SSc female patients with interstitial lung involvement and in 75 healty individuals by ARMS-PCR. In our study no significant difference was found in codon 10, codon 25 genotype frequencies between patient with SSc and the control group (p = 0.676, 0.375, respectively). Our findings suggest that codon 10 and 25 polymorphism cannot be related with SSc for Turkish population.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Büyük U,Ates O,Dalyan L,Müsellim B,Ongen G,Topal-Sarikaya Adoi
10.1002/cbf.1649subject
Has Abstractpub_date
2010-06-01 00:00:00pages
274-7issue
4eissn
0263-6484issn
1099-0844journal_volume
28pub_type
杂志文章abstract::The effect of influenza strains A (H3N2) and B, isolated during the seasons of 1994 and 1995 in the Czech Republic, on MDCK cells was studied. Various concentrations of virus and conditions of nutrition were used during the cell culture. The virus replication and consequently fragmentation of genomic DNA together with...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(19970601)15:2<87::AID-CBF7
更新日期:1997-06-01 00:00:00
abstract::The possibility that inositol lipid metabolism is related to nuclear events accompanying steroid hormone action has been investigated by comparing lipid phosphorylation and breakdown in normal rat liver nuclei and in hypo- and hypercortisolemic conditions. Lipid phosphorylation in vitro showed the presence of diacylgl...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290120308
更新日期:1994-09-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290040109
更新日期:1986-01-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290040307
更新日期:1986-07-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2820
更新日期:2012-07-01 00:00:00
abstract::Mitochondrial, endoplasmic reticular and plasma membrane fractions were isolated by a new method from control male Fischer 344 rats and rats given CCl4 by gavage. After 1 h of CCl4 treatment, rats were in glucose and pancreatic hormone balance but plasma levels of T3 and T4 were decreased 29 and 22%, respectively. Aft...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.934
更新日期:2002-03-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290110406
更新日期:1993-12-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3350
更新日期:2018-08-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290010304
更新日期:1983-10-01 00:00:00
abstract::The effects of several novel monosaccharides upon thymidine incorporation into both normal and tumour cells were investigated. The monosaccharide 2-deoxy-3-[1-(R)-(ethoxycarbonyl)ethyl]- alpha-D-allo-pyranose had the most inhibitory effect on proliferation, with the (S)-enantiomer having less inhibitory effects. The c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199712)15:4<243::AID-CBF74
更新日期:1997-12-01 00:00:00
abstract::Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is consid...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(200001/03)18:1<23::AID-CBF
更新日期:2000-03-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1553
更新日期:2009-04-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The in...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2913
更新日期:2012-12-01 00:00:00
abstract::Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2933
更新日期:2013-10-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1835
更新日期:2012-04-01 00:00:00
abstract::The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine at three different doses (10, 50 and 100 mg kg(-1) bw) for five consecutive days. On the fifth day of treatment, mice ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2834
更新日期:2012-10-01 00:00:00
abstract::Extracellular acylglycerols are hydrolysed by lipases active at the surface of intact fat cells isolated from rat or human adipose tissue. During short-term incubation, rat fat cells hydrolyse di-[3H]oleyl-[14C]glycerol at a rate of 70 +/- 7.7 mU/10(6) cells (mean +/- S.E.) versus 440 +/- 62 mU/10(6) cells for the hyd...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290050304
更新日期:1987-07-01 00:00:00
abstract::Growth factors are biologically-active mediators that bind to specific receptors on target cells and regulate genes involved in cell growth, wound healing and regeneration. In the case of wound healing, a proper wound dressing is needed to cover the wound area, protect the damaged tissue, and if possible to activate c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1121
更新日期:2004-11-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.1327
更新日期:2006-11-01 00:00:00
abstract::The object was to determine the influence of dietary vitamin E, selenium and their combination on the fatty acid content of erythrocytes, bone marrow and spleen lipids of Akkaraman lambs. After supplementation for 15 days, the amount of all fatty acids was slightly higher (p < 0.05) in the vitamin E as compared to the...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199703)15:1<1::AID-CBF694>
更新日期:1997-03-01 00:00:00
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journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1612
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1294
更新日期:2006-11-01 00:00:00
abstract::The levels of polyamines and their synthesizing enzymes in squamous cell carcinoma of prostate implanted in intact as well as castrated male rats were determined after certain hormonal manipulations. The tumour was found to grow with an identical rate in non-castrated and castrated rats. Polyamine content and activiti...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290030305
更新日期:1985-07-01 00:00:00
abstract::Chemotherapeutic drugs that induce DNA damage have the potential to kill cancer cells, but DNA repair protects cells from damage-induced cell death. Thus, eliminating DNA repair is a potential approach to overcome cell drug resistance. In this study, we observed that the gene expression of C-terminal binding protein i...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3430
更新日期:2019-10-01 00:00:00
abstract::Cyclophilin A (Cyp A), a member of the peptidyl-prolyl isomerase (PPI) family, may function as a molecular signalling switch. Comparative proteomic studies have identified Cyp A as a potential downstream target of protein kinase B (Akt). This study confirmed that Cyp A is a downstream effector of the phosphatidylinosi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3156
更新日期:2015-12-01 00:00:00
abstract::The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290080406
更新日期:1990-10-01 00:00:00
abstract::The modification of myeloperoxidase and lactoperoxidase with 2-(O-methoxypolethylene glycol)-4, 6-dichloro-s-triazine, an activated polyethylene glycol (PEG1), was investigated. The modification caused a shift of the Soret band in the light absorption spectrum, from 430 nm to 418 nm in the case of myeloperoxidase (nat...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199806)16:2<123::AID-CBF77
更新日期:1998-06-01 00:00:00
abstract::Deficiency in neutrophils (neutropenia) caused by mutations in neutrophil elastase (NE, ELA2) has been extensively investigated. Monocytes and neutrophils are derived from a common myeloid progenitor; therefore, ELA2 mutations can also influence monocyte development. These effects have not been well described. In this...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2900
更新日期:2013-06-01 00:00:00
abstract::The gene expression of heme oxygenase-1 (HO-1) was studied in mammalian cell lines exposed to hyperoxia. Northern blot analysis demonstrated that hyperoxic exposure increased the HO-1 mRNA levels in various types of cells, including human hepatoma (HepG2) cells. This increase was time- and dose-dependent, and reversib...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199809)16:3<183::AID-CBF78
更新日期:1998-09-01 00:00:00