解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Melanin plays an important role in determining skin colour. Apoptosis of melanocytes and defect in melanin production cause vitiligo. Various studies have been conducted to treat the disease, but its treatment is still difficult. Therefore, this study aimed to investigate the effect of spermidine, which is known as an...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3619
更新日期:2021-01-25 00:00:00
abstract::Human adipose-derived stromal/stem cells (ASC) have immunomodulatory properties and the potential to differentiate into several cell lines, important for application in regenerative medicine. However, the contamination with dermal fibroblasts (FIB) can impair the beneficial effects of ASC in cell therapy. It is then e...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3610
更新日期:2021-01-03 00:00:00
abstract::Glaucoma is optic neuropathy that is characterized by progressive neurodegeneration of the retinal ganglion cells (RGCs) and axons. This condition will lead to visual impairment and bring glaucoma to become the second cause of blindness globally. Neuroprotection in glaucoma is needed to prevent the progression of opti...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3567
更新日期:2021-01-01 00:00:00
abstract::Incidence and mortality rates of cancer continue to increase greatly despite the improved diagnostic and therapeutic methods. Based on GLOBOCAN estimates, the numbers of new cancer cases reported in 2018 were ~18.1 million, while the numbers of cancer mortalities were ~9.6 million. It remains difficult to diagnose mos...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3601
更新日期:2020-11-06 00:00:00
abstract::Cardiovascular diseases are known to be the most fatal diseases worldwide. Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common cardiovascular diseases. According to the World Health Organization estimates, ischaemic heart disease is the leading global cause of death, causing more th...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3587
更新日期:2020-09-06 00:00:00
abstract::Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell-fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development....
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3582
更新日期:2020-08-25 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, and thymidine phosphorylase (TP) is a regulator of angiogenesis. To investigate the biological activities of TP in ICC, we established human cholangiocarcinoma RBE cell lines overexpressing TP or silencing TP. Overexpression of TP en...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3541
更新日期:2020-08-01 00:00:00
abstract::Glioblastoma is one of the most malignant tumors and causes the high mortality in cancer patients. Currently, there is no highly efficient therapy against glioblastoma. Therefore, searching for a new molecular target to anti-glioblastoma therapy is urgent and necessary. In this study, we elucidated the role of Signal ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3518
更新日期:2020-07-01 00:00:00
abstract::Because of limited treatment options, preeclampsia (PE) is the leading cause of perinatal morbidity and mortality worldwide. Recently, lncRNA TDRG1 is reported to be aberrantly down-regulated in PE placenta, and the abnormal expression of TDRG1 might play a key or partial role in PE development. In this study, we foun...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3480
更新日期:2020-06-01 00:00:00
abstract::Current studies have shown that circular RNAs (circRNAs) and microRNAs (miRNAs) are closely related in acute myocardial infarction (AMI). Previous studies have shown that miR-125b promotes fibrosis and up-regulates in cardiac fibroblasts (CFs), and further experiments showed that circ_LAS1L had multiple binding sites ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3486
更新日期:2020-06-01 00:00:00
abstract::Based on central dogma of genetics, protein is the embodiment and executor of genetic function, post-translational modifications (PTMs) of protein are particularly important and involved in almost all aspects of cell biology and pathogenesis. Studies have shown that ionizing radiation (IR) alters gene expression much ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3467
更新日期:2020-04-01 00:00:00
abstract::Endometrial cancer (EC) is the most common gynaecologic malignancy in western countries and has been reported to account for about 7% of female malignant tumours and 20% to 30% of female genital system malignant tumours. Accumulating evidence showed the expression of human trophoblast cell surface antigen 2 (Trop2) wa...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3450
更新日期:2020-03-01 00:00:00
abstract::Regeneration remains a major challenge in skeletal muscle repair after injury. Recently, transforming growth factor-β (TGF-β)/Smad pathway was found to play an important role in inhibiting myogenesis, a crucial stage in skeletal muscle regeneration. In our previous study, microRNA-122-5p (miR-122) was proved to have t...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3460
更新日期:2020-03-01 00:00:00
abstract::Mesenchymal epithelial transition (C-MET) factor overexpression has been found in many types of cancer and has served as an important molecular target for therapeutic intervention. However, the role of C-MET in retinoblastoma remains largely unclear. The present study aimed to investigate the potential role and mechan...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3464
更新日期:2020-03-01 00:00:00
abstract::Dexmedetomidine (DEX) is a highly selective α2 adrenoceptor agonist. In this study, we evaluated the antalgic effect of DEX on acetic acid-induced acute inflammatory visceral pain (AIVP) in rats. Additionally, we evaluated the role of Nrf2 signalling in antinociception. We administered acetic acid to male Sprague Dawl...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3456
更新日期:2020-01-01 00:00:00
abstract::Endothelial dysfunction is recognized as the initial detectable stage of cardiovascular disease, a serious complication of diabetes. In this study, we evaluated effects of myricetin on high glucose (HG)-elicited oxidative damage in human umbilical vein endothelial cells (HUVECs). The cells were pre-incubated with myri...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3442
更新日期:2020-01-01 00:00:00
abstract::Ras-GTPases regulate many central signalling pathways in the cell. Hypoxia induces nitrosative/oxidative stress and dysregulates Ras-dependent downstream processes. H-Ras possesses two cysteine residues (C181 and C184) in the C-termini, which are palmitoylated once or twice. Palmitoylation is sufficient for promoting ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3431
更新日期:2019-10-01 00:00:00
abstract::Chemotherapeutic drugs that induce DNA damage have the potential to kill cancer cells, but DNA repair protects cells from damage-induced cell death. Thus, eliminating DNA repair is a potential approach to overcome cell drug resistance. In this study, we observed that the gene expression of C-terminal binding protein i...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3430
更新日期:2019-10-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C) is an angiogenic and lymphangiogenic growth factor. Recent research has revealed the role for VEGF-C in regulating autophagy by interacting with a nontyrosine kinase receptor, neuropilin-2 (NRP-2). However, whether VEGF-C participates in regulating cell survival and autoph...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3402
更新日期:2019-06-01 00:00:00
abstract::The ataxia-telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy. We focused on the functions of AT...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3385
更新日期:2019-04-01 00:00:00
abstract::While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3350
更新日期:2018-08-01 00:00:00
abstract::The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3333
更新日期:2018-06-01 00:00:00
abstract::Ovarian cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely used in locally advanced ovarian cancer patients. Acquired or de novo cisplatin resistance remains the barrier to patient survival, and the mechanisms of cisplatin resistance are still not well understood. In th...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3319
更新日期:2018-03-01 00:00:00
abstract::It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR-2909 has emerged to regulate genes involve...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3323
更新日期:2018-03-01 00:00:00
abstract::The p53 protein plays a critical role in suppression of tumour growth; its regulation is not fully understood. Leukaemia/lymphoma-related factor (LRF) promotes tumour cell growth. This study tests a hypothesis that LRF inhibits p53 expression in colon cancer cells. In this study, human colon cancer cell lines, LIM1215...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3287
更新日期:2017-10-01 00:00:00
abstract::Glucocorticoids are important for skeletal muscle energy metabolism, regulating glucose utilization, insulin sensitivity, and muscle mass. Nicotinamide adenine dinucleotide phosphate-dependent 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)-mediated glucocorticoid activation in the sarcoplasmic reticulum (SR) is in...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3272
更新日期:2017-07-01 00:00:00
abstract::Bisphenol A (BPA) can be accumulated into the human body via food intake and inhalation. Numerous studies indicated that BPA can trigger the tumorigenesis and progression of cancer cells. Laryngeal cancer cells can be exposed to BPA directly via food digestion, while there were very limited data concerning the effect ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3265
更新日期:2017-06-01 00:00:00
abstract::Retinopathy of prematurity, a leading cause of visual impairment in low birth-weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3264
更新日期:2017-06-01 00:00:00
abstract::Epidermal growth factor plays a major role in breast cancer cell proliferation, survival, and metastasis. Quercetin, a bioactive flavonoid, is shown to exhibit anticarcinogenic effects against various cancers including breast cancer. Hence, the present study was designed to evaluate the effects of gold nanoparticles-c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3266
更新日期:2017-06-01 00:00:00
abstract::The goal of the study was to estimate the effect of a selective V-type H+ -ATPase inhibitor bafilomycin A1 and nicotinic acid adenine dinucleotide phosphate (NAADP) on energetic processes in NK/Ly cell by directly measuring the respiration of isolated mitochondria and ATPase activities. NAADP (7 μM) increased the acti...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3231
更新日期:2016-12-01 00:00:00
abstract::Glioma is one of the most common brain tumors and one of the most aggressive cancers. Although extensive progress has been made regarding to the diagnosis and treatment, the mortality in glioma patients is still high. Therefore, finding new therapeutic targets to the glioma is critical to the advancement in cancer tre...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3225
更新日期:2016-10-01 00:00:00
abstract::Ceramide is known to trigger apoptosis of nucleated cells and eryptosis of erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Besides ceramide, stimulators of eryptosis include increase of cytosolic Ca(2+) -activity ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3196
更新日期:2016-07-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a common complication of premature birth that seriously affects the survival rate and quality of life among preterm neonates. Long non-coding RNAs (lncRNAs) have been implicated in many human diseases. However, the role of lncRNAs in the pathogenesis of BPD remains poorly understood...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3190
更新日期:2016-07-01 00:00:00
abstract::WIN55,212-2, a cannabinoid receptor agonist, can activate cannabinoid receptors, which has proven anti-tumour effects in several tumour types. Studies showed that WIN can inhibit tumour cell proliferation and induce apoptosis in diverse cancers. However, the role and mechanism of WIN in osteosarcoma are still unclear....
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3194
更新日期:2016-07-01 00:00:00
abstract::Cyclophilin A (Cyp A), a member of the peptidyl-prolyl isomerase (PPI) family, may function as a molecular signalling switch. Comparative proteomic studies have identified Cyp A as a potential downstream target of protein kinase B (Akt). This study confirmed that Cyp A is a downstream effector of the phosphatidylinosi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3156
更新日期:2015-12-01 00:00:00
abstract::During remodelling of pulmonary artery, marked proliferation of pulmonary artery smooth muscle cells (PASMCs) occurs, which contributes to pulmonary hypertension. Thromboxane A2 (TxA2) has been shown to produce pulmonary hypertension. The present study investigates the inhibitory effect of epigallocatechin-3-gallate (...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3136
更新日期:2015-10-01 00:00:00
abstract::The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage measure. Indeed, before any investigation on the mechanism of action of different molecules, it is important to perform a cytotoxicity assay. Among the different...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3135
更新日期:2015-08-01 00:00:00
abstract::Corneal scarring is the result of a disease, infection or injury. The resulting scars cause significant loss of vision or even blindness. To-date, the most successful treatment is corneal transplantation, but it does not come without side effects. One of the corneal dystrophies that are correlated with corneal scarrin...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3122
更新日期:2015-07-01 00:00:00
abstract::Development and homeostasis of multicellular organisms require interactions between neighbouring cells. We recently established an in vitro model of cell-cell interaction based on a collagen vitrigel membrane. We have now examined the role of neural cells in retinal homeostasis by coculture of human retinal pigment ep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3082
更新日期:2015-01-01 00:00:00
abstract::Regulation of extracellular matrix (ECM) components is essential for tissue homeostasis and function. We screened a small peptide that induces ECM protein synthesis for its usefulness in protecting keratinocytes. In this report, we demonstrate that myristoyl tetrapeptide Ala-Ala-Pro-Val (mAAPV) stimulates the expressi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3070
更新日期:2014-12-01 00:00:00