Abstract:
:Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The intracellular calcium level was significantly reduced, whereas the cAMP level was significantly augmented in RCC as compared with adjacent grossly normal renal parenchyma.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Sharma U,Singh SK,Rajendra Pdoi
10.1002/cbf.2913subject
Has Abstractpub_date
2012-12-01 00:00:00pages
619-22issue
8eissn
0263-6484issn
1099-0844journal_volume
30pub_type
杂志文章abstract:OBJECTIVE:Hydrogen peroxide (H(2)O(2)) is a potent reactive oxygen species that causes cardiomyocytes injury. As an important cytokine, interleukin 6 (IL-6) has cardioprotective effects as it plays an essential role in the late phase of preconditioning. Our work is to investigate if IL-6 preconditioning has protective ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2820
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of artemisinin on the proliferation and apoptosis of rat vascular smooth muscle cells (VSMCs). METHOD:Primary rat VSMCs were treated with various doses of artemisinin. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2995
更新日期:2014-03-01 00:00:00
abstract::Diabetes is associated with increased reactivity of the renal vascular bed to endothelin-1 (ET-1). It has been observed that diabetes is associated with over-expression of ET(A)- and ET(B)-receptors in the rat renal cortex. However it is not known if these receptors are over-expressed in the renal artery. The objectiv...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1253
更新日期:2006-09-01 00:00:00
abstract::WIN55,212-2, a cannabinoid receptor agonist, can activate cannabinoid receptors, which has proven anti-tumour effects in several tumour types. Studies showed that WIN can inhibit tumour cell proliferation and induce apoptosis in diverse cancers. However, the role and mechanism of WIN in osteosarcoma are still unclear....
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3194
更新日期:2016-07-01 00:00:00
abstract::The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1310
更新日期:2007-07-01 00:00:00
abstract::Reactive oxygen metabolites play an important role in ischemia-reperfusion related gastric injury. Primary sources of reactive oxygen metabolites seem to be the xanthine/xanthine oxidase system and neutrophils accumulating within the reperfused tissue. Tissue myeloperoxidase activity is an important index of neutrophi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1251
更新日期:2006-09-01 00:00:00
abstract::Sexually-transmitted diseases (STD) can facilitate the progression of HIV-1 infection. Among them, as we have previously demonstrated, cervico-vaginal dysplasia-papillomavirus (HPV)-induced, together with HSV-2 co-infection, seems to be correlated with a more evident immunodepression in HIV-positive women, compared wi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.950
更新日期:2002-09-01 00:00:00
abstract::The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3058
更新日期:2014-10-01 00:00:00
abstract::Rat liver nonparenchymal cells (NPC) were prepared by pronase digestion and purified on discontinuous gradients on Nycodenz. Morphological and biochemical characterization of cell suspensions showed that they were free of contamination by hepatocytes. We have confirmed the usefulness of pyruvate kinase activity in mon...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290070406
更新日期:1989-10-01 00:00:00
abstract::Analysis of free nucleotide composition of both avian thrombocytes and pig platelets showed quantitative differences in the level of adenine nucleotides. 3H-adenine taken up by turkey thrombocytes was metabolized mainly to adenine nucleotides was not released after thrombin action. Thrombin liberated non-radioactive a...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290020310
更新日期:1984-07-01 00:00:00
abstract::The aim of this work was to determine the role of intraperitoneally-administered vitamin E and selenium on the biochemical and haematological parameters in the blood of rats. Thirty-two adult male Wistar rats were used in this study. All rats were randomly divided into four groups. The first group was used as the cont...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199906)17:2<143::AID-CBF80
更新日期:1999-06-01 00:00:00
abstract::Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture o...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1517
更新日期:2008-12-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a common complication of premature birth that seriously affects the survival rate and quality of life among preterm neonates. Long non-coding RNAs (lncRNAs) have been implicated in many human diseases. However, the role of lncRNAs in the pathogenesis of BPD remains poorly understood...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3190
更新日期:2016-07-01 00:00:00
abstract::The phospholipid profiles of the myocardium (from 10- and 18-day old chick embryos and 13-day old chick) and their in vitro response to the endogenous lipolytic enzymes (mainly of the phospholipase group) at pH 7.4 and 38 degrees C for 60 min were analyzed by TLC technology and densitometry. Cardiolipin (CL) was shown...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1422
更新日期:2007-09-01 00:00:00
abstract::Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on biochemical and hematologic...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2806
更新日期:2012-06-01 00:00:00
abstract::Retinopathy of prematurity, a leading cause of visual impairment in low birth-weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3264
更新日期:2017-06-01 00:00:00
abstract::We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were rando...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1469
更新日期:2008-06-01 00:00:00
abstract::Lipopolysaccharide (LPS)-induced inflammatory factors production by the cerebral cortical glial cells in two sides of the murine brain are different. To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1β (IL-1β) and nitric oxide (NO) resp...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1718
更新日期:2011-01-01 00:00:00
abstract::Aberrant innate and adaptive immune responsed to allergens and environmental pollutants lead to respiratory allergic disease such as asthma. In this study, we focused on toll-like receptor-4 (TLR4) expressed on airway epithelium to identify house dust mite (HDM)-regulated allergic inflammation via TLR4 signaling pathw...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1697
更新日期:2010-10-01 00:00:00
abstract::The present investigation focused, firstly, on the effects of oral administration of thymoquinone (TQ) on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase activity in hepatic, cardiac and kidney tissues of normal mice. Superoxide dismutase (SOD; E.C:1.15.1.1), catalase (CAT; E.C:1.11.1.6), glutathio...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.968
更新日期:2002-06-01 00:00:00
abstract::One of the most damaging effects of reactive oxygen species (ROS) is lipid peroxidation, the end-product of which is malondialdehyde (MDA). This study was aimed to evaluate erythrocyte MDA levels during fracture healing in rats. Thirty male rats were used and the rats were divided into two groups to serve as controls ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1199
更新日期:2005-03-01 00:00:00
abstract::Glaucoma is optic neuropathy that is characterized by progressive neurodegeneration of the retinal ganglion cells (RGCs) and axons. This condition will lead to visual impairment and bring glaucoma to become the second cause of blindness globally. Neuroprotection in glaucoma is needed to prevent the progression of opti...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3567
更新日期:2021-01-01 00:00:00
abstract::The vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease. Howeve...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1781
更新日期:2011-10-01 00:00:00
abstract::Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.2847
更新日期:2012-10-01 00:00:00
abstract::The modification of myeloperoxidase and lactoperoxidase with 2-(O-methoxypolethylene glycol)-4, 6-dichloro-s-triazine, an activated polyethylene glycol (PEG1), was investigated. The modification caused a shift of the Soret band in the light absorption spectrum, from 430 nm to 418 nm in the case of myeloperoxidase (nat...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199806)16:2<123::AID-CBF77
更新日期:1998-06-01 00:00:00
abstract::The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower costs and/or increase efficacies for using BMP-2. In this study, we de...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1615
更新日期:2009-12-01 00:00:00
abstract::Hyperglycemia induces overproduction of superoxide and it is related to diabetic complications. In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1683
更新日期:2010-08-01 00:00:00
abstract::A previous study showing that ethanol (ETOH) blocked [3H]choline incorporation into phosphatidylcholine (PC) suggested an inhibition of PC biosynthesis in human leukemic monocyte-like U937 cells. The mechanism of the inhibitory action of ETOH was investigated. Cells were pulsed with [3H]choline for 30 min and chased i...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290120107
更新日期:1994-01-01 00:00:00
abstract::Free radicals are now well known to damage cellular components. To investigate whether age and thyroid level affect peroxidation speed, we examined the levels of malondialdehyde and antioxidant enzyme activities in different age groups of hypothyroid rats. Hypothyroidism was induced in 30- and 60-day-old Wistar Albino...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1031
更新日期:2003-12-01 00:00:00
abstract::Cyclophosphamide (CP) has potential urotoxicity such as hemorrhagic cystitis (HC). 2-Mercaptoethane sulfonate (mesna) has been widely used as an effective agent against CP-induced cystitis, but significant HC has still been encountered clinically. In recent studies, mesna was shown to be more effective if combined wit...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1347
更新日期:2007-09-01 00:00:00