Abstract:
:The aim of this work was to determine the role of intraperitoneally-administered vitamin E and selenium on the biochemical and haematological parameters in the blood of rats. Thirty-two adult male Wistar rats were used in this study. All rats were randomly divided into four groups. The first group was used as the control. The second group was intraperitoneally administered with vitamin E (+/-(-)alpha-tocopheroryl acetate, 10 mg day-1), the third group with Se (Na2SeO3 0.2 mg over a day), and the fourth group with vitamin E and Se (vitamin E 10 mg + Na2SeO3 0.2 mg over a day). This administration was done for 5 weeks. Blood samples were taken from animals at the end of the dosage period and biochemical parameters in serum samples and haematological parameters in total blood were determined. The levels of total cholesterol (p < 0.01) and number of white blood cell (p < 0.001) in blood were significantly higher in the vitamin E group than in the control group. The levels of ALP, total cholesterol (p < 0.01) and number of white blood cells (p < 0.01) in blood were significantly higher in the selenium group than in the controls. The levels of glucose (p < 0.05), ALP (p < 0.01), total cholesterol (p < 0.001) and number of white blood cells (p < 0.01) were higher in the vitamin E and selenium combined group than in the controls. Other parameters considered within this trial (ALT, LDH, creatinine, albumin, total protein, amylase, creatine kinase, HDL triglycerides, total lipid, sodium, chloride, uric acids, red blood cell, haemoglobin, packed cell volume, MCV, MCH, MCHC) did not show statistically significant differences between the control and injected groups. The results indicated that blood glucose and total cholesterol levels, ALP activity and white blood cell counts were significantly increased by intraperitoneal administration of vitamin E and selenium in rats.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Cay M,Naziroğlu Mdoi
10.1002/(SICI)1099-0844(199906)17:2<143::AID-CBF80subject
Has Abstractpub_date
1999-06-01 00:00:00pages
143-8issue
2eissn
0263-6484issn
1099-0844pii
10.1002/(SICI)1099-0844(199906)17:2<143::AID-CBF80journal_volume
17pub_type
杂志文章abstract::Rat liver mitochondria were stored at 0-4 degrees C for several days using an appropriate medium and energy source. The elimination of the majority of microsomes and lysosomes, that normally contaminate isolated mitochondria, had a positive effect in preservation of respiratory control, P:O ratio, and monoamine oxidas...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290030407
更新日期:1985-10-01 00:00:00
abstract::Proliferating-cell nuclear antigen (PCNA), also known as cyclin, is synthesized in proliferative cells and recently was identified as DNA polymerase-delta auxiliary protein. In this paper, the association of PCNA to the proliferative cells of plants was analysed using both autoantibodies to PCNA obtained from a patien...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290100209
更新日期:1992-06-01 00:00:00
abstract::Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2933
更新日期:2013-10-01 00:00:00
abstract::Lipopolysaccharide (LPS)-induced inflammatory factors production by the cerebral cortical glial cells in two sides of the murine brain are different. To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1β (IL-1β) and nitric oxide (NO) resp...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1718
更新日期:2011-01-01 00:00:00
abstract::Uptake of polyamines has been investigated extensively in many cells, but not in placenta, where the polyamine-polyamine oxidase system is supposed to have an immunoregulatory function in pregnancy. Due to the importance of the transfer in this tissue, we have started this study. JAR human placental choriocarcinoma ce...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.664
更新日期:1996-09-01 00:00:00
abstract::Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.2847
更新日期:2012-10-01 00:00:00
abstract::Reduced and oxidized glutathione (GSH and GSSG), protein-bound glutathione, lipid peroxidation and antioxidant enzyme activities were determined in the erythrocyte lysates and membranes of type I and II alcoholics in order to clarify the effect of age-of-onset and the duration of the alcohol consumption on erythrocyte...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1125
更新日期:2005-01-01 00:00:00
abstract::A method for the quantification of energy consuming processes described by Siems et al. for reticulocytes and by Müller et al. for ascites tumour cells was applied to balance the ATP-consumption of isolated rat hepatocytes. On the basis of decreased coupled respiration rates following the specific inhibition of energy...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290080407
更新日期:1990-10-01 00:00:00
abstract::Ovarian cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely used in locally advanced ovarian cancer patients. Acquired or de novo cisplatin resistance remains the barrier to patient survival, and the mechanisms of cisplatin resistance are still not well understood. In th...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3319
更新日期:2018-03-01 00:00:00
abstract::Hyperglycemia induces overproduction of superoxide and it is related to diabetic complications. In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1683
更新日期:2010-08-01 00:00:00
abstract::While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3350
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1294
更新日期:2006-11-01 00:00:00
abstract::The subcellular distribution of newly absorbed iron in isolated mouse duodenal enterocytes was investigated by analytical subcellular fractionation using sucrose density gradient centifugation. Two major peaks of mucosal 59Fe activity were observed: one soluble and one particulate (density 1.18-1.20 g ml-1). The latte...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290080205
更新日期:1990-04-01 00:00:00
abstract::The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3333
更新日期:2018-06-01 00:00:00
abstract::Rat liver nonparenchymal cells (NPC) were prepared by pronase digestion and purified on discontinuous gradients on Nycodenz. Morphological and biochemical characterization of cell suspensions showed that they were free of contamination by hepatocytes. We have confirmed the usefulness of pyruvate kinase activity in mon...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290070406
更新日期:1989-10-01 00:00:00
abstract::Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1512
更新日期:2008-10-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an endothelium-specific mitogen and a promising inducer of angiogenesis and lymphangiogenesis. The VEGF receptors on endothelial cell membrane include the tyrosine kinases VEGFR-1 (Flt-1), VEGFR-2 (Flk-1/KDR) and VEGFR-3 (Flt-4). KDR is a major mediator of mitogenic, angiog...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1829
更新日期:2012-03-01 00:00:00
abstract::Glioma is one of the most common brain tumors and one of the most aggressive cancers. Although extensive progress has been made regarding to the diagnosis and treatment, the mortality in glioma patients is still high. Therefore, finding new therapeutic targets to the glioma is critical to the advancement in cancer tre...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3225
更新日期:2016-10-01 00:00:00
abstract::Sprouty1 protein belongs to a family of receptor tyrosine kinase-mediated signaling inhibitors, whose members are usually regulated by growth factors to form a negative feedback loop. Correspondingly fluctuations of Sprouty1 mRNA in response to single growth factors have been observed. In this report, we investigate S...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2976
更新日期:2014-01-01 00:00:00
abstract::Retinopathy of prematurity, a leading cause of visual impairment in low birth-weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3264
更新日期:2017-06-01 00:00:00
abstract::Nuclear T3 specific binding sites were characterized by Scatchard analyses of L-125I-T3 binding to nuclei extracted from freshly isolated and 1, 2 and 6 day-cultured hepatocytes. The results demonstrate a marked decrease in T3 binding capacity of nuclei extracted from 1 day-cultured cells followed by an almost complet...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290030203
更新日期:1985-04-01 00:00:00
abstract::The time-course of incorporation of NBD-cholesterol by macrophages (Ma) and lymphocytes (LY) obtained from untreated and thioglycollate-injected (thio) rats was investigated. NBD-cholesterol incorporation was also examined in Ma obtained from untreated rats and stimulated in vitro by lipopolysaccharide (LPS) and phorb...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1048
更新日期:2004-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC-MSCs ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2843
更新日期:2012-12-01 00:00:00
abstract::UFD1L is the human homologue of the yeast ubiquitin fusion degradation 1 (Ufd1) gene and maps on chromosome 22q11.2 in the typically deleted region (TDR) for DiGeorge/velocardiofacial syndromes (DGS/VCFS). In yeast, Ufd1 protein is involved in a degradation pathway for ubiquitin fused products (UFD pathway). Several s...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1021
更新日期:2003-09-01 00:00:00
abstract::The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.976
更新日期:2002-12-01 00:00:00
abstract::We have shown previously the intercalation geometry of a series of acenaphtho [1,2-b] pyrrole derivatives with DNA double helix in vitro. In this report we chose a couple of intercalating analogues and a Chinese traditional medicine Tanshinone IIA as probes to investigate the response of DNA damage sensor ataxia-telan...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1510
更新日期:2008-10-01 00:00:00
abstract::Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF-beta is a pluripotent cytokine in a wide range of cell types. In parti...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1649
更新日期:2010-06-01 00:00:00
abstract::MicroRNA (miRNAs) are short non-coding RNA molecules that downregulate gene expression at post-transcriptional level. miRNAs are post-transcriptional regulators of gene expression important for neuron development and function. This report demonstrated that a putative and chemically synthesized miRNA rno-mir-541 played...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1747
更新日期:2011-06-01 00:00:00
abstract::The protective effects of betaine in ethanol hepatotoxicity were investigated in 24 female wistar albino rats. Animals were divided into three groups: control, ethanol and ethanol + betaine group. Animals were fed liquid diets and consumed approximately 60 diet per day. Rats were fed ethanol 8 kg(- 1) day(- 1). The et...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.926
更新日期:2001-12-01 00:00:00
abstract::Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is consid...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(200001/03)18:1<23::AID-CBF
更新日期:2000-03-01 00:00:00