Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance.

abstract：:Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell-fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development....

journal_title：Cell biochemistry and function

authors： Li X,Li Y,Li S,Li H,Yang C,Lin J

更新日期：2020-08-25 00:00:00

abstract：:Analysis of free nucleotide composition of both avian thrombocytes and pig platelets showed quantitative differences in the level of adenine nucleotides. 3H-adenine taken up by turkey thrombocytes was metabolized mainly to adenine nucleotides was not released after thrombin action. Thrombin liberated non-radioactive a...

journal_title：Cell biochemistry and function

authors： Wachowicz B

更新日期：1984-07-01 00:00:00

abstract：:While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of...

journal_title：Cell biochemistry and function

authors： Muto A,Sugihara Y,Shibakawa M,Oshima K,Matsuda T,Nadano D

更新日期：2018-08-01 00:00:00

abstract：:The present investigation focused, firstly, on the effects of oral administration of thymoquinone (TQ) on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase activity in hepatic, cardiac and kidney tissues of normal mice. Superoxide dismutase (SOD; E.C:1.15.1.1), catalase (CAT; E.C:1.11.1.6), glutathio...

journal_title：Cell biochemistry and function

authors： Mansour MA,Nagi MN,El-Khatib AS,Al-Bekairi AM

更新日期：2002-06-01 00:00:00

abstract：:The acute effects of isolated and combined L-alanine (L-Ala) and L-glutamine (L-Gln) on liver gluconeogenesis, ureagenesis and glycaemic recovery during short-term insulin-induced hypoglycaemia (IIH) were investigated. For this purpose, 24-h fasted rats that received intraperitoneal injection of regular insulin (1.0 U...

journal_title：Cell biochemistry and function

authors： Gazola VA,Garcia RF,Curi R,Pithon-Curi TC,Mohamad MS,Hartmann EM,Barrena HC,Bazotte RB

更新日期：2007-03-01 00:00:00

abstract：:The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 1...

journal_title：Cell biochemistry and function

authors： Yildirim A,Altinkaynak K,Aksoy H,Sahin YN,Akcay F

更新日期：2004-07-01 00:00:00

abstract：:Rat liver mitochondria were stored at 0-4 degrees C for several days using an appropriate medium and energy source. The elimination of the majority of microsomes and lysosomes, that normally contaminate isolated mitochondria, had a positive effect in preservation of respiratory control, P:O ratio, and monoamine oxidas...

journal_title：Cell biochemistry and function

authors： Higuti IH,Murata LY,Stencel M,De Paiva Campello A,Do Nascimento AJ

更新日期：1985-10-01 00:00:00

abstract：:Mesenchymal epithelial transition (C-MET) factor overexpression has been found in many types of cancer and has served as an important molecular target for therapeutic intervention. However, the role of C-MET in retinoblastoma remains largely unclear. The present study aimed to investigate the potential role and mechan...

journal_title：Cell biochemistry and function

authors： Dai H,Zeng W,Luo H

更新日期：2020-03-01 00:00:00

abstract：:The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...

journal_title：Cell biochemistry and function

authors： Coskun ZM,Bolkent S

更新日期：2014-10-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a common complication of premature birth that seriously affects the survival rate and quality of life among preterm neonates. Long non-coding RNAs (lncRNAs) have been implicated in many human diseases. However, the role of lncRNAs in the pathogenesis of BPD remains poorly understood...

journal_title：Cell biochemistry and function

authors： Bao TP,Wu R,Cheng HP,Cui XW,Tian ZF

更新日期：2016-07-01 00:00:00

abstract：:Mitochondrial, endoplasmic reticular and plasma membrane fractions were isolated by a new method from control male Fischer 344 rats and rats given CCl4 by gavage. After 1 h of CCl4 treatment, rats were in glucose and pancreatic hormone balance but plasma levels of T3 and T4 were decreased 29 and 22%, respectively. Aft...

journal_title：Cell biochemistry and function

authors： Hemmings SJ,Pulga VB,Tran ST,Uwiera RR

更新日期：2002-03-01 00:00:00

abstract：:The biochemical and quantitative cytochemical assays of the activity of uridine diphosphoglucose dehydrogenase (UDPG-D) have produced perplexing results. It is now shown that the perplexity may be due to the possibility that the coenzyme (NAD) required for UDPG-D activity, may be acting as a substrate for a second deh...

journal_title：Cell biochemistry and function

authors： Mehdizadeh S,Bitensky L,Chayen J

更新日期：1991-04-01 00:00:00

abstract：:Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti-inflammatory effect of trikatu, a herbal compound in monosodium urate crystal-induced inflammation in rats, an experimental model f...

journal_title：Cell biochemistry and function

authors： Murunikkara V,Rasool M

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have demonstrated that germ-like cells could be differentiated from human umbilical cord mesenchymal stem cells (hUC-MSCs) in vitro. Whether the sexuality of hUC-MSCs affects the formation efficiency of germ-like cells derived from hUC-MSCs is still unclear. To clearly test the formation efficiency of o...

journal_title：Cell biochemistry and function

authors： Qiu P,Bai Y,Pan S,Li W,Liu W,Hua J

更新日期：2013-07-01 00:00:00

abstract：:The heart responds to an increased demand arising due to physiological stimuli or pathological insults by hypertrophy of myocytes. Reactive oxygen species (ROS) have recently been identified as the molecular intermediates in the translation of mechanical stimuli to cellular response. Different signal transduction path...

journal_title：Cell biochemistry and function

authors： Adiga IK,Nair RR

更新日期：2008-04-01 00:00:00

abstract：:Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is consid...

journal_title：Cell biochemistry and function

authors： Ustündağ B,Canatan H,Cinkilinç N,Halifeoğlu I,Bahçecioğlu IH

更新日期：2000-03-01 00:00:00

abstract：:Glucocorticoids are important for skeletal muscle energy metabolism, regulating glucose utilization, insulin sensitivity, and muscle mass. Nicotinamide adenine dinucleotide phosphate-dependent 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)-mediated glucocorticoid activation in the sarcoplasmic reticulum (SR) is in...

journal_title：Cell biochemistry and function

authors： Zielinska AE,Fletcher RS,Sherlock M,Doig CL,Lavery GG

更新日期：2017-07-01 00:00:00

abstract：:CYR61 is one of the six proteins of the CCN family of proteins known to play diverse roles in angiogenesis, cellular proliferation, survival, migration and wound healing. However, the specific function of CYR61 in cancer is unclear, and the literature remains controversial. We used quantitative real-time PCR to establ...

journal_title：Cell biochemistry and function

authors： Jandova J,Beyer TE,Meuillet EJ,Watts GS

更新日期：2012-12-01 00:00:00

abstract：:Rat liver nonparenchymal cells (NPC) were prepared by pronase digestion and purified on discontinuous gradients on Nycodenz. Morphological and biochemical characterization of cell suspensions showed that they were free of contamination by hepatocytes. We have confirmed the usefulness of pyruvate kinase activity in mon...

journal_title：Cell biochemistry and function

authors： Rich K,Lodola A

更新日期：1989-10-01 00:00:00

abstract：:Hyperglycemia induces overproduction of superoxide and it is related to diabetic complications. In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (...

journal_title：Cell biochemistry and function

authors： Ibuki FK,Simões A,Nogueira FN

更新日期：2010-08-01 00:00:00

abstract：:We constructed the significant low-expression P-glycoprotein (ABCB1) inhibited transport and signal network in chimpanzee compared with high-expression (fold change ≥2) the human left cerebrum in GEO data set, by using integration of gene regulatory activated and inhibited network inference method with gene ontology (...

journal_title：Cell biochemistry and function

authors： Lin H,Wang L,Jiang M,Huang J,Qi L

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Hydrogen peroxide (H(2)O(2)) is a potent reactive oxygen species that causes cardiomyocytes injury. As an important cytokine, interleukin 6 (IL-6) has cardioprotective effects as it plays an essential role in the late phase of preconditioning. Our work is to investigate if IL-6 preconditioning has protective ...

journal_title：Cell biochemistry and function

authors： Jia Y,Zhou F,Deng P,Fan Q,Li C,Liu Y,Fu X,Zhou Y,Xu X,Sun X

更新日期：2012-07-01 00:00:00

abstract：:In murine thymocytes cyclic nucleotide phosphodiesterase is represented by cAMP- and cGMP-specific forms. cAMP and cGMP phosphodiesterase activities showed anomalous kinetic behaviour indicative of 'low' and 'high' affinity enzyme forms. Sucrose density gradient centrifugation resolved only 'low' affinity forms of cAM...

journal_title：Cell biochemistry and function

authors： Sobolev AS,Rybalkin SD

更新日期：1986-07-01 00:00:00

abstract：:Incidence and mortality rates of cancer continue to increase greatly despite the improved diagnostic and therapeutic methods. Based on GLOBOCAN estimates, the numbers of new cancer cases reported in 2018 were ~18.1 million, while the numbers of cancer mortalities were ~9.6 million. It remains difficult to diagnose mos...

journal_title：Cell biochemistry and function

authors： El-Ashmawy NE,Al-Ashmawy GM,Hamouda SM

更新日期：2020-11-06 00:00:00

abstract：:Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant...

journal_title：Cell biochemistry and function

authors： Takeshita H,Tsubota E,Takatsuka H,Kunito T,Fujihara J

更新日期：2008-10-01 00:00:00

abstract：:The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose...

journal_title：Cell biochemistry and function

authors： Pitsillides AA,Blake SM,Glynn LE,Bitensky L,Chayen J

更新日期：1990-10-01 00:00:00

abstract：:Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...

journal_title：Cell biochemistry and function

authors： Komiyama H,Miyake K,Asai K,Mizuno K,Shimada T

更新日期：2014-01-01 00:00:00

abstract：:The main purpose of the present investigation was to study the effect of cloturin on aerobic glycolysis, endogenous and exogenous respiration and the level of ATP in both Ehrlich ascites carcinoma (EAC) and P388 murine leukaemia cells incubated in vitro. Also its effect on the level of total (T-SH) and non-protein (NP...

journal_title：Cell biochemistry and function

authors： Miko M,Krepelka J,Melka M

更新日期：1992-06-01 00:00:00

abstract：:Pi depletion of proximal tubule cells isolated from mouse kidney results in a decrease in the cell content of fructose-2,6-bisphosphate and an increase in the rate of gluconeogenesis from pyruvate, malate and succinate. Gluconeogenesis from glycerol is unaffected by Pi depletion. Introduction of fructose-2,6-bisphosph...

journal_title：Cell biochemistry and function

authors： Nakagawa T,Butterworth PJ

更新日期：1990-01-01 00:00:00

abstract：:Nuclear T3 specific binding sites were characterized by Scatchard analyses of L-125I-T3 binding to nuclei extracted from freshly isolated and 1, 2 and 6 day-cultured hepatocytes. The results demonstrate a marked decrease in T3 binding capacity of nuclei extracted from 1 day-cultured cells followed by an almost complet...

journal_title：Cell biochemistry and function

authors： Goglia F,Gallo G,Palmero S,Voci A,Fugassa E

更新日期：1985-04-01 00:00:00