Abstract:
:Nuclear T3 specific binding sites were characterized by Scatchard analyses of L-125I-T3 binding to nuclei extracted from freshly isolated and 1, 2 and 6 day-cultured hepatocytes. The results demonstrate a marked decrease in T3 binding capacity of nuclei extracted from 1 day-cultured cells followed by an almost complete recovery within 6 days. The affinity constant value of nuclear receptor sites is significantly decreased in 1 day-cultured cells with a subsequent partial recovery. The affinity and capacity pattern of nuclear T3 binding sites appears to be in line with the delayed responses of hepatocyte primary cultures to T3.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Goglia F,Gallo G,Palmero S,Voci A,Fugassa Edoi
10.1002/cbf.290030203subject
Has Abstractpub_date
1985-04-01 00:00:00pages
91-4issue
2eissn
0263-6484issn
1099-0844journal_volume
3pub_type
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