Abstract:
:The effects of either radiation or hyperthermia on the differentiation potential of NG108-15, a neuroblastoma-glioma hybrid cell line, were studied. After radiation and hyperthermia, the outgrowth of neurites from NG108-15 cells was potentiated, and polarizing current and voltage pulses induced a distinct action potential and a diphasic (inward following outward) current, respectively. An increase in the specific activity of acetylcholinesterase was also observed. In addition, both treatments induced an elevation of the concentration of intracellular calcium in some cells. The increase in intracellular calcium concentration caused by applying the calcium ionophore, A23187, induced differentiation. It is suggested that both the radiation- and the hyperthermia-induced increases of electrical excitability and acetylcholinesterase activity may have originated from an increase in intracellular Ca2+ concentration.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Sugihara M,Fujita Y,Enomoto K,Maeno T,Ishida Tdoi
10.1002/cbf.290120209subject
Has Abstractpub_date
1994-06-01 00:00:00pages
137-42issue
2eissn
0263-6484issn
1099-0844journal_volume
12pub_type
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