Environmental modulation of the inhibitory action of D-mannoheptulose upon D-glucose metabolism in isolated rat pancreatic islets.

Abstract:

:In pancreatic islets prepared from fed rats and incubated at a low concentration (1.7 mM) of D-glucose, D-mannoheptulose (10.0 mM) virtually fails to affect the metabolism of the hexose. Likewise, in islets from starved rats, the relative extent of the inhibitory action of D-mannoheptulose upon D-glucose metabolism is much more marked at high (16.7 mM) than low (1.7 mM) hexose concentration. Nevertheless, despite decreasing the metabolism of D-glucose, starvation augments the sensitivity to D-mannoheptulose in the islets incubated at a low concentration of the hexose, D-galactose, but not D-fructose, also augments the inhibitory action of D-mannoheptulose upon D-glucose metabolism in islets prepared from fed rats and exposed to the low concentration of D-glucose. A comparable situation prevails in islets exposed to 2-ketoisocaproate. Forskolin, however, which decreases D-glucose catabolism in the islets from fed rats exposed to 1.7 mM D-glucose, fails to affect significantly the inhibitory action of D-mannoheptulose on D-glucose metabolism. It is proposed that hexoses transported by the same carrier as D-glucose and non-glucidic nutrient secretagogues somehow increase D-mannoheptulose uptake by the islet cells. The latter two conditions may be operative in islets exposed to a high concentration of D-glucose, this accounting for the exquisite sensitivity to D-mannoheptulose of glucose-stimulated islets.

journal_name

Cell Biochem Funct

authors

Picton S,Malaisse WJ

doi

10.1002/(SICI)1099-0844(199903)17:1<65::AID-CBF812

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

65-71

issue

1

eissn

0263-6484

issn

1099-0844

pii

10.1002/(SICI)1099-0844(199903)17:1<65::AID-CBF812

journal_volume

17

pub_type

杂志文章
  • Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells.

    abstract::The aim of the present study is to evaluate the proliferation- and migration-enhancing effects of ginseng and its component, ginsenoside (Rg1) on RSC96 Schwann cells. We investigated the molecular signaling pathways, which include: (1) survival signaling, IGFs-IGFIR-Akt-Bcl2 and proliferative signaling, cell cycle fac...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1554

    authors: Lu MC,Lai TY,Hwang JM,Chen HT,Chang SH,Tsai FJ,Wang HL,Lin CC,Kuo WW,Huang CY

    更新日期:2009-06-01 00:00:00

  • Inositol lipid phosphorylation and breakdown in rat liver nuclei is affected by hydrocortisone blood levels.

    abstract::The possibility that inositol lipid metabolism is related to nuclear events accompanying steroid hormone action has been investigated by comparing lipid phosphorylation and breakdown in normal rat liver nuclei and in hypo- and hypercortisolemic conditions. Lipid phosphorylation in vitro showed the presence of diacylgl...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290120308

    authors: Santi P,Marmiroli S,Falcieri E,Bertagnolo V,Capitani S

    更新日期:1994-09-01 00:00:00

  • Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat.

    abstract::This study was designed to investigate the effect of L-carnitine in ischaemia and reperfusion of the rat kidney. Rats were randomly allocated into three groups. Group I (control group; n = 6) received no treatment. Group II (isotonic saline group; n = 6), received 2 ml of isotonic saline 15 min before the renal ischae...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1159

    authors: Görür S,Bağdatoğlu OT,Polat G

    更新日期:2005-05-01 00:00:00

  • Different progress of MDCK cell death after infection by two different influenza virus isolates.

    abstract::The effect of influenza strains A (H3N2) and B, isolated during the seasons of 1994 and 1995 in the Czech Republic, on MDCK cells was studied. Various concentrations of virus and conditions of nutrition were used during the cell culture. The virus replication and consequently fragmentation of genomic DNA together with...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0844(19970601)15:2<87::AID-CBF7

    authors: Hornícková Z

    更新日期:1997-06-01 00:00:00

  • Triiodothyronine receptor sites in serum-free cultured hepatocytes from adult rat liver.

    abstract::Nuclear T3 specific binding sites were characterized by Scatchard analyses of L-125I-T3 binding to nuclei extracted from freshly isolated and 1, 2 and 6 day-cultured hepatocytes. The results demonstrate a marked decrease in T3 binding capacity of nuclei extracted from 1 day-cultured cells followed by an almost complet...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290030203

    authors: Goglia F,Gallo G,Palmero S,Voci A,Fugassa E

    更新日期:1985-04-01 00:00:00

  • Localization of putative gonadotrophin releasing hormone receptor protein in the anterior pituitary.

    abstract::Specific binding of a fully biologically active 125I-gonadotrophin releasing hormone (GnRH) to isolated anterior pituitary cells is time dependent, saturable and the concentration dependent binding curves exhibit positive cooperativity. Binding to intact or solubilized plasma membranes and an affinity purified GnRH re...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290020405

    authors: Zolman JC,Theodoropoulos TJ

    更新日期:1984-10-01 00:00:00

  • The matrix protein CCN1/CYR61 is required for α(V)β5-mediated cancer cell migration.

    abstract::CYR61 is one of the six proteins of the CCN family of proteins known to play diverse roles in angiogenesis, cellular proliferation, survival, migration and wound healing. However, the specific function of CYR61 in cancer is unclear, and the literature remains controversial. We used quantitative real-time PCR to establ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2853

    authors: Jandova J,Beyer TE,Meuillet EJ,Watts GS

    更新日期:2012-12-01 00:00:00

  • Cyclical mechanical stretch enhances degranulation and IL-4 secretion in RBL-2H3 mast cells.

    abstract::Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2973

    authors: Komiyama H,Miyake K,Asai K,Mizuno K,Shimada T

    更新日期:2014-01-01 00:00:00

  • Age-dependent changes in in vivo ethanol metabolism and in the activity of hepatic enzymes involved in ethanol oxidation and microsomal functions.

    abstract::The study of the influence of the age of the animals (13 to 53 weeks) on the rate of ethanol metabolism in vivo and the total activity of liver alcohol dehydrogenase and microsomal ethanol oxidizing system showed a progressive decline with age. These effects were observed concomitantly with a diminution in the content...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290060103

    authors: Fernandez V,Kriz A,Videla LA

    更新日期:1988-01-01 00:00:00

  • Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells.

    abstract::The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine at three different doses (10, 50 and 100 mg kg(-1) bw) for five consecutive days. On the fifth day of treatment, mice ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2834

    authors: Naghshvar F,Abianeh SM,Ahmadashrafi S,Hosseinimehr SJ

    更新日期:2012-10-01 00:00:00

  • Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.

    abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, and thymidine phosphorylase (TP) is a regulator of angiogenesis. To investigate the biological activities of TP in ICC, we established human cholangiocarcinoma RBE cell lines overexpressing TP or silencing TP. Overexpression of TP en...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3541

    authors: Li S,Yang H,Li K,Fan G,Deng L,Xu C

    更新日期:2020-08-01 00:00:00

  • Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread.

    abstract::Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章,评审

    doi:10.1002/cbf.2847

    authors: Farooqi AA,Naqi A,Qureshi MZ,Rana A,Khan A,Riaz AM,Afzal SM,Rasheed N,Bhatti S

    更新日期:2012-10-01 00:00:00

  • Proliferating cell nuclear antigen (PCNA/cyclin) in plant proliferating cells: immunohistochemical and quantitative analysis using autoantibody and murine monoclonal antibodies to PCNA.

    abstract::Proliferating-cell nuclear antigen (PCNA), also known as cyclin, is synthesized in proliferative cells and recently was identified as DNA polymerase-delta auxiliary protein. In this paper, the association of PCNA to the proliferative cells of plants was analysed using both autoantibodies to PCNA obtained from a patien...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290100209

    authors: Daidoji H,Takasaki Y,Nakane PK

    更新日期:1992-06-01 00:00:00

  • Cytochrome P450 in highly purified suspension of nonparenchymal liver cells.

    abstract::Rat liver nonparenchymal cells (NPC) were prepared by pronase digestion and purified on discontinuous gradients on Nycodenz. Morphological and biochemical characterization of cell suspensions showed that they were free of contamination by hepatocytes. We have confirmed the usefulness of pyruvate kinase activity in mon...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290070406

    authors: Rich K,Lodola A

    更新日期:1989-10-01 00:00:00

  • Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells.

    abstract::Ras-GTPases regulate many central signalling pathways in the cell. Hypoxia induces nitrosative/oxidative stress and dysregulates Ras-dependent downstream processes. H-Ras possesses two cysteine residues (C181 and C184) in the C-termini, which are palmitoylated once or twice. Palmitoylation is sufficient for promoting ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3431

    authors: Goloshvili G,Barbakadze T,Mikeladze D

    更新日期:2019-10-01 00:00:00

  • Dietary influence of selenium on the incidence of N-nitrosodiethylamine-induced hepatoma with reference to drug and glutathione metabolizing enzymes.

    abstract::The dietary administration of selenium (sodium selenite; 4 p.p.m.) daily has been found to be highly effective in reducing the incidence of cancer induced by N-nitrosodiethylamine (DEN) in Wistar strain rats. Selenium treatment either before initiation, during initiation and selection/phenobarbital promotion phases of...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.979

    authors: Thirunavukkarasu C,Prince Vijeya Singh J,Thangavel M,Selvendiran K,Sakthisekaran D

    更新日期:2002-12-01 00:00:00

  • Influence of culture conditions on monoamine oxidase A and B activity in rat astrocytes.

    abstract::Astroglial cells dispersed from newborn rat hemispheres were established in medium supplemented with 20 per cent fetal calf serum (FBS) and then grown to a confluent monolayer in the presence of 10 per cent FBS or charcoal-stripped FBS (CS). Type 1 astrocytes were subcultured and either maintained under the same condi...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.645

    authors: Carlo P,Del Rio M,Violani E,Sciaba L,Picotti GB

    更新日期:1996-03-01 00:00:00

  • Effects of vitamin A and insulin on the antioxidative state of diabetic rat heart: a comparison study with combination treatment.

    abstract::Because elevated oxidative stress may exacerbate cardiovascular complications of diabetes mellitus, the current study aimed to investigate the effects of treatment with either vitamin A, an antioxidant, or with insulin on lipid peroxidation products and antioxidant enzyme activities of diabetic rat heart. Also to eval...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.957

    authors: Zobali F,Avci A,Canbolat O,Karasu C

    更新日期:2002-06-01 00:00:00

  • Localization of biotransformational enzymes along the crypt-villus axis of the rat intestine. Evaluation of two cell isolation procedures.

    abstract::Rat intestinal epithelial cells were isolated by EDTA-chelation, combined with gentle shaking (modified Weiser procedure) or with strong longitudinal vibration (Harrison/Webster procedure). Both methods yield large numbers of viable cells and are relatively easy to use. Electronmicroscopical and biochemical data indic...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290020208

    authors: Koster AS,Borm PJ,Dohmen MR,Noordhoek J

    更新日期:1984-04-01 00:00:00

  • Tissue malondialdehyde and adenosine triphosphatase level after experimental liver ischaemia-reperfusion damage.

    abstract::Functional irregularities due to damage after ischaemia-reperfusion vary depending upon the organs affected. High energy phosphates such as ATP and ADP are destroyed after ischaemia-reperfusion damage. Subsequently, protons and inorganic phosphates accumulate within the cells and the proton pumps such as adenosine tri...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.912

    authors: Ilhan N,Halifeoglu I,Ozercan HI,Ilhan N

    更新日期:2001-09-01 00:00:00

  • Roles for VEGF-C/NRP-2 axis in regulating renal tubular epithelial cell survival and autophagy during serum deprivation.

    abstract::Vascular endothelial growth factor C (VEGF-C) is an angiogenic and lymphangiogenic growth factor. Recent research has revealed the role for VEGF-C in regulating autophagy by interacting with a nontyrosine kinase receptor, neuropilin-2 (NRP-2). However, whether VEGF-C participates in regulating cell survival and autoph...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3402

    authors: Chang X,Yang Q,Zhang C,Zhang Y,Liang X,Liu Y,Xu G

    更新日期:2019-06-01 00:00:00

  • Analysis of transforming growth factor beta 1 (TGF-beta1) gene polymorphisms in Turkish patients with scleroderma.

    abstract::Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF-beta is a pluripotent cytokine in a wide range of cell types. In parti...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1649

    authors: Büyük U,Ates O,Dalyan L,Müsellim B,Ongen G,Topal-Sarikaya A

    更新日期:2010-06-01 00:00:00

  • Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits.

    abstract::The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.976

    authors: Irmak MK,Fadillioğlu E,Güleç M,Erdoğan H,Yağmurca M,Akyol O

    更新日期:2002-12-01 00:00:00

  • Effect of oxidative stress on rat thyrocyte iodide metabolism.

    abstract::Thyroid cells fall into the type of cells functioning during continuous production of high H(2)O(2) concentrations. We studied the effect of H(2)O(2)-induced oxidative stress (0.1, 1.0 and 10.0 mM) on the activities of the key steps of iodide metabolism (uptake, oxidation and organification) in thyrocytes cultivated i...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1452

    authors: Nadolnik LI,Niatsetskaya ZV,Lupachyk SV

    更新日期:2008-04-01 00:00:00

  • Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes.

    abstract::Cardiac hypertrophy is characterized by remodeling of the extracellular matrix (ECM). Integrins are cell-surface molecules that link the ECM to the cellular cytoskeleton where they play roles as signaling molecules and transducers of mechanical force. To clarify the possible roles of integrins in cardiac myocyte hyper...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.988

    authors: Kim DJ,Park SH,Lim CS,Chun JS,Kim JK,Song WK

    更新日期:2003-03-01 00:00:00

  • Subcellular localization of recently-absorbed iron in mouse duodenal enterocytes: identification of a basolateral membrane iron-binding site.

    abstract::The subcellular distribution of newly absorbed iron in isolated mouse duodenal enterocytes was investigated by analytical subcellular fractionation using sucrose density gradient centifugation. Two major peaks of mucosal 59Fe activity were observed: one soluble and one particulate (density 1.18-1.20 g ml-1). The latte...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290080205

    authors: Snape S,Simpson RJ,Peters TJ

    更新日期:1990-04-01 00:00:00

  • STAT1 determines aggressiveness of glioblastoma both in vivo and in vitro through wnt/β-catenin signalling pathway.

    abstract::Glioblastoma is one of the most malignant tumors and causes the high mortality in cancer patients. Currently, there is no highly efficient therapy against glioblastoma. Therefore, searching for a new molecular target to anti-glioblastoma therapy is urgent and necessary. In this study, we elucidated the role of Signal ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3518

    authors: Zhao L,Li X,Su J,Wang Gong F,Lu J,Wei Y

    更新日期:2020-07-01 00:00:00

  • Ca2+ responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization.

    abstract::The molecular mechanisms involved in GPCR-initiated signaling cascades where the two receptors share the same signaling cascade, such as thyrotropin-releasing hormone (TRH) and angiotensin II (ANG II), are still far from being understood. Here, we analyzed hormone-induced Ca(2+) responses and the process of desensitiz...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1453

    authors: Ostasov P,Krusek J,Durchankova D,Svoboda P,Novotny J

    更新日期:2008-03-01 00:00:00

  • Isolation and characterization of mesenchymal stem cells from whole human umbilical cord applying a single enzyme approach.

    abstract::Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC-MSCs ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2843

    authors: Zhang H,Zhang B,Tao Y,Cheng M,Hu J,Xu M,Chen H

    更新日期:2012-12-01 00:00:00

  • Stimulation of growth factor synthesis in skin wounds using tissue extract (G-90) from the earthworm Eissenia foetida.

    abstract::Growth factors are biologically-active mediators that bind to specific receptors on target cells and regulate genes involved in cell growth, wound healing and regeneration. In the case of wound healing, a proper wound dressing is needed to cover the wound area, protect the damaged tissue, and if possible to activate c...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1121

    authors: Grdisa M,Popović M,Hrzenjak T

    更新日期:2004-11-01 00:00:00