STAT1 determines aggressiveness of glioblastoma both in vivo and in vitro through wnt/β-catenin signalling pathway.

abstract：:Proteins destined for degradation by the ubiquitin-proteasome system are labelled with a 76-amino acid peptide, ubiquitin, through a series of conjugation steps by the E1, E2 and E3 enzymes respectively. Ubiquitin carboxy-terminal hydrolase 37 (UCH37) belongs to the UCH proteases family that deubiquitinates ubiquitin-...

journal_title：Cell biochemistry and function

authors： Chen Z,Niu X,Li Z,Yu Y,Ye X,Lu S,Chen Z

更新日期：2011-03-01 00:00:00

abstract：:The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower costs and/or increase efficacies for using BMP-2. In this study, we de...

journal_title：Cell biochemistry and function

authors： Okada M,Sangadala S,Liu Y,Yoshida M,Reddy BV,Titus L,Boden SD

更新日期：2009-12-01 00:00:00

abstract：:We have shown previously the intercalation geometry of a series of acenaphtho [1,2-b] pyrrole derivatives with DNA double helix in vitro. In this report we chose a couple of intercalating analogues and a Chinese traditional medicine Tanshinone IIA as probes to investigate the response of DNA damage sensor ataxia-telan...

journal_title：Cell biochemistry and function

authors： Zhang Z,Wang Y,Zhang J,Song T,Qian X

更新日期：2008-10-01 00:00:00

abstract：:1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and 1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) are structural analogues of ceramide; inhibiting UDP-glucose : ceramide glucosyltransferase. After treatment with these synthetic ceramide analogues the expression of glucosphingolipid decreases, while ...

journal_title：Cell biochemistry and function

authors： Kovács P,Pintér M,Csaba G

更新日期：2000-12-01 00:00:00

abstract：:In moderate physical exercise, the transition from predominantly anaerobic towards predominantly aerobic metabolism is a key step to improve performance. Increase in the supply of oxygen and nutrients, such as free fatty acids (FFA) and glucose, which accompanies high blood flow, is required for this transition. The m...

journal_title：Cell biochemistry and function

authors： Hirabara SM,Silveira LR,Abdulkader FR,Alberici LC,Procopio J,Carvalho CR,Pithon-Curi TC,Curi R

更新日期：2006-11-01 00:00:00

abstract：:MicroRNA (miRNAs) are short non-coding RNA molecules that downregulate gene expression at post-transcriptional level. miRNAs are post-transcriptional regulators of gene expression important for neuron development and function. This report demonstrated that a putative and chemically synthesized miRNA rno-mir-541 played...

journal_title：Cell biochemistry and function

authors： Zhang J,Zhang J,Liu LH,Zhou Y,Li YP,Shao ZH,Wu YJ,Li MJ,Fan YY,Shi HJ

更新日期：2011-06-01 00:00:00

abstract：:The time-course of incorporation of NBD-cholesterol by macrophages (Ma) and lymphocytes (LY) obtained from untreated and thioglycollate-injected (thio) rats was investigated. NBD-cholesterol incorporation was also examined in Ma obtained from untreated rats and stimulated in vitro by lipopolysaccharide (LPS) and phorb...

journal_title：Cell biochemistry and function

authors： Portioli Silva EP,Peres CM,Roberto Mendonça J,Curi R

更新日期：2004-01-01 00:00:00

abstract：:Beta-glucosidase activity was evaluated in situ by means of fluorogenic probes in normal human fibroblasts and fibroblasts from homozygous carriers of the Gaucher trait. Probe internalization, targeting to lysosomes and post-cleavage probe retention were the primary concerns. Internalization and targeting were attempt...

journal_title：Cell biochemistry and function

authors： Kohen E,Kohen C,Hirschberg JG,Santus R,Grabowski G,Mangel W,Gatt S,Prince J

更新日期：1993-09-01 00:00:00

abstract：:The influence of the 1,4-dihydropyridines (DHPs), water-soluble glutapyrone available as sodium, potassium and ammonium salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-DHP-4-carboxamide)glutaric acid, from one side, and a lipophylic cerebrocrast, 2-propoxyethyl 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-DHP-3,5-di...

journal_title：Cell biochemistry and function

authors： Velena A,Skujiņs A,Svirskis S,Bisenieks E,Uldriķis J,Poikans J,Duburs G,Klusa V

更新日期：1997-09-01 00:00:00

abstract：:Ras-GTPases regulate many central signalling pathways in the cell. Hypoxia induces nitrosative/oxidative stress and dysregulates Ras-dependent downstream processes. H-Ras possesses two cysteine residues (C181 and C184) in the C-termini, which are palmitoylated once or twice. Palmitoylation is sufficient for promoting ...

journal_title：Cell biochemistry and function

authors： Goloshvili G,Barbakadze T,Mikeladze D

更新日期：2019-10-01 00:00:00

abstract：:The effects of several novel monosaccharides upon thymidine incorporation into both normal and tumour cells were investigated. The monosaccharide 2-deoxy-3-[1-(R)-(ethoxycarbonyl)ethyl]- alpha-D-allo-pyranose had the most inhibitory effect on proliferation, with the (S)-enantiomer having less inhibitory effects. The c...

journal_title：Cell biochemistry and function

authors： Colquhoun A,Alaluf S,Bradley A,Gemmell N,Gibbs G,Osborn HM,Harwood LM,Newsholme EA

更新日期：1997-12-01 00:00:00

abstract：:Glioma is one of the most common brain tumors and one of the most aggressive cancers. Although extensive progress has been made regarding to the diagnosis and treatment, the mortality in glioma patients is still high. Therefore, finding new therapeutic targets to the glioma is critical to the advancement in cancer tre...

journal_title：Cell biochemistry and function

authors： Wu H,Li J,Xu D,Jv D,Meng X,Qiao P,Cui T,Shi B

更新日期：2016-10-01 00:00:00

abstract：:Mitochondrial proton leak can account for almost 20% of oxygen consumption and it is generally accepted that this process contributes to basal metabolism. In order to clarify the role of basal proton leak in testicular mitochondria, we performed a comparative study with kidney and liver mitochondrial fractions. Proton...

journal_title：Cell biochemistry and function

authors： Rodrigues AS,Lacerda B,Moreno AJ,Ramalho-Santos J

更新日期：2010-04-01 00:00:00

abstract：:Development and homeostasis of multicellular organisms require interactions between neighbouring cells. We recently established an in vitro model of cell-cell interaction based on a collagen vitrigel membrane. We have now examined the role of neural cells in retinal homeostasis by coculture of human retinal pigment ep...

journal_title：Cell biochemistry and function

authors： Ko JA,Hirata J,Yamane K,Sonoda KH,Kiuchi Y

更新日期：2015-01-01 00:00:00

abstract：:The effects of either radiation or hyperthermia on the differentiation potential of NG108-15, a neuroblastoma-glioma hybrid cell line, were studied. After radiation and hyperthermia, the outgrowth of neurites from NG108-15 cells was potentiated, and polarizing current and voltage pulses induced a distinct action poten...

journal_title：Cell biochemistry and function

authors： Sugihara M,Fujita Y,Enomoto K,Maeno T,Ishida T

更新日期：1994-06-01 00:00:00

abstract：:The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...

journal_title：Cell biochemistry and function

authors： Coskun ZM,Bolkent S

更新日期：2014-10-01 00:00:00

abstract：:Thyroid cells fall into the type of cells functioning during continuous production of high H(2)O(2) concentrations. We studied the effect of H(2)O(2)-induced oxidative stress (0.1, 1.0 and 10.0 mM) on the activities of the key steps of iodide metabolism (uptake, oxidation and organification) in thyrocytes cultivated i...

journal_title：Cell biochemistry and function

authors： Nadolnik LI,Niatsetskaya ZV,Lupachyk SV

更新日期：2008-04-01 00:00:00

abstract：:The aim of the present study is to evaluate the proliferation- and migration-enhancing effects of ginseng and its component, ginsenoside (Rg1) on RSC96 Schwann cells. We investigated the molecular signaling pathways, which include: (1) survival signaling, IGFs-IGFIR-Akt-Bcl2 and proliferative signaling, cell cycle fac...

journal_title：Cell biochemistry and function

authors： Lu MC,Lai TY,Hwang JM,Chen HT,Chang SH,Tsai FJ,Wang HL,Lin CC,Kuo WW,Huang CY

更新日期：2009-06-01 00:00:00

abstract：:Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant...

journal_title：Cell biochemistry and function

authors： Takeshita H,Tsubota E,Takatsuka H,Kunito T,Fujihara J

更新日期：2008-10-01 00:00:00

abstract：:The p53 protein plays a critical role in suppression of tumour growth; its regulation is not fully understood. Leukaemia/lymphoma-related factor (LRF) promotes tumour cell growth. This study tests a hypothesis that LRF inhibits p53 expression in colon cancer cells. In this study, human colon cancer cell lines, LIM1215...

journal_title：Cell biochemistry and function

authors： Zhu M,Wang P,Feng F,Li MY

更新日期：2017-10-01 00:00:00

abstract：:The vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease. Howeve...

journal_title：Cell biochemistry and function

authors： Schaun MI,Dipp T,Rossato Jda S,Wilhelm EN,Pinto R,Rech A,Plentz RD,Homem de Bittencourt PI,Reischak-Oliveira A

更新日期：2011-10-01 00:00:00

abstract：:In response to concanavalin A, cytoplasmic calcium movement was observed in human platelets, both in the presence of 1 mM Ca2+ or 1 mM EGTA in the medium. Concanavalin A also caused the activation of inositide turnover and the production of inositol phosphates, suggesting that activation of phospholipase C occurs. The...

journal_title：Cell biochemistry and function

authors： Torti M,Balduini C,Ramaschi G,Sinigaglia F

更新日期：1992-03-01 00:00:00

abstract：:The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 1...

journal_title：Cell biochemistry and function

authors： Yildirim A,Altinkaynak K,Aksoy H,Sahin YN,Akcay F

更新日期：2004-07-01 00:00:00

abstract：:A method for the quantification of energy consuming processes described by Siems et al. for reticulocytes and by Müller et al. for ascites tumour cells was applied to balance the ATP-consumption of isolated rat hepatocytes. On the basis of decreased coupled respiration rates following the specific inhibition of energy...

journal_title：Cell biochemistry and function

authors： Schneider W,Siems W,Grune T

更新日期：1990-10-01 00:00:00

abstract：:The heart responds to an increased demand arising due to physiological stimuli or pathological insults by hypertrophy of myocytes. Reactive oxygen species (ROS) have recently been identified as the molecular intermediates in the translation of mechanical stimuli to cellular response. Different signal transduction path...

journal_title：Cell biochemistry and function

authors： Adiga IK,Nair RR

更新日期：2008-04-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of ferulic acid at different doses (50 mg kg(-1) alternative day and 50 mg kg(-1) daily) on the streptozotocin (STZ)-induced post-diabetes rat testicular damage. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). Rats treated wit...

journal_title：Cell biochemistry and function

authors： Roy S,Metya SK,Rahaman N,Sannigrahi S,Ahmed F

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effect of artemisinin on the proliferation and apoptosis of rat vascular smooth muscle cells (VSMCs). METHOD:Primary rat VSMCs were treated with various doses of artemisinin. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro...

journal_title：Cell biochemistry and function

authors： Wang HY,Huang RP,Han P,Xue DB,Li HB,Liu B,Shan P,Wang QS,Li KS,Li HL

更新日期：2014-03-01 00:00:00

abstract：:We constructed the significant low-expression P-glycoprotein (ABCB1) inhibited transport and signal network in chimpanzee compared with high-expression (fold change ≥2) the human left cerebrum in GEO data set, by using integration of gene regulatory activated and inhibited network inference method with gene ontology (...

journal_title：Cell biochemistry and function

authors： Lin H,Wang L,Jiang M,Huang J,Qi L

更新日期：2012-10-01 00:00:00

abstract：:Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...

journal_title：Cell biochemistry and function

authors： Komiyama H,Miyake K,Asai K,Mizuno K,Shimada T

更新日期：2014-01-01 00:00:00

abstract：:The microsomes from dehydroepiandrosterone (DHEA)-supplemented animals are good hydroxyl radical scavengers, as demonstrated through electron spin resonance and deoxyribose degradation. The ability of DHEA-supplemented microsomes to react with superoxide radical was also demonstrated through the inhibition of nitroblu...

journal_title：Cell biochemistry and function

authors： Tamagno E,Aragno M,Boccuzzi G,Gallo M,Parola S,Fubini B,Poli G,Danni O

更新日期：1998-03-01 00:00:00