Abstract:
:The vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease. However, little is known about the effects of concurrent (aerobic + strength) training on that. For a comparison of the effects of aerobic and concurrent physical training on endothelial function, oxidative stress parameters and the immunoinflammatory activity of monocytes/macrophages, 20 adult male volunteers of middle age were divided into a concurrent training (CT) programme group and an aerobic training group. The glutathione disulphide to glutathione ratio (GSSG/GSH) and plasma lipoperoxide (LPO) levels, as well as flow-mediated dilation (FMD), monocyte/macrophage functional activity (zymosan phagocytosis), body lipid profiles, aerobic capacity (maximal oxygen uptake) and strength parameters (one-repetition maximum test), were measured before and after the exercise training programmes. The CT exhibited reduced acute effects of exercise on the GSSG/GSH ratio, plasma LPO levels and zymosan phagocytosis. The CT also displayed improved lipid profiles, glycaemic control, maximal oxygen uptake and one-repetition maximum test values. In both the aerobic training and the CT, training improved the acute responses to exercise, as inferred from a decrease in the GSSG/GSH ratios. The aerobic sessions did not alter basal levels of plasma LPO or macrophage phagocytic activity but improved FMD values as well as lipid profiles and glycaemic control. In summary, both training programmes improve systemic redox status and antioxidant defences. However, the aerobic training was more efficient in improving FMD in the individuals studied.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Schaun MI,Dipp T,Rossato Jda S,Wilhelm EN,Pinto R,Rech A,Plentz RD,Homem de Bittencourt PI,Reischak-Oliveira Adoi
10.1002/cbf.1781subject
Has Abstractpub_date
2011-10-01 00:00:00pages
534-42issue
7eissn
0263-6484issn
1099-0844journal_volume
29pub_type
杂志文章abstract::Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The in...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2913
更新日期:2012-12-01 00:00:00
abstract::Betulin is a principal component of birch bark and is known to possess a broad range of biological activities, including antiinflammatory, antiviral and anticancer actions. The present study was carried out in vitro to clarify the influence of betulin on melanocortin (MC) receptor-ergic signalling by using COS-7 cells...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1427
更新日期:2007-09-01 00:00:00
abstract::The object was to determine the influence of dietary vitamin E, selenium and their combination on the fatty acid content of erythrocytes, bone marrow and spleen lipids of Akkaraman lambs. After supplementation for 15 days, the amount of all fatty acids was slightly higher (p < 0.05) in the vitamin E as compared to the...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199703)15:1<1::AID-CBF694>
更新日期:1997-03-01 00:00:00
abstract::The phospholipid profiles of the myocardium (from 10- and 18-day old chick embryos and 13-day old chick) and their in vitro response to the endogenous lipolytic enzymes (mainly of the phospholipase group) at pH 7.4 and 38 degrees C for 60 min were analyzed by TLC technology and densitometry. Cardiolipin (CL) was shown...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1422
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of artemisinin on the proliferation and apoptosis of rat vascular smooth muscle cells (VSMCs). METHOD:Primary rat VSMCs were treated with various doses of artemisinin. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2995
更新日期:2014-03-01 00:00:00
abstract::Bone tumor incidence in women peaks at age 50-60, coinciding with the menopause. That estrogen (E2) and triiodothyronine (T3) interact in bone metabolism has been well established. However, few data on the action of these hormones are available. Our purpose was to determine the role of E2 and T3 in the expression of b...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1408
更新日期:2008-01-01 00:00:00
abstract::We studied the effect of PTH (10-100 nM) on transductive mechanisms (adenylate cyclase activity, Ca2+ metabolism, IP3 levels) in cell cultures derived from normal and otosclerotic human bone fragments. The cultured cells were osteoblast-like but with calcitonin-receptors still present and with PTH receptors coupled wi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290110406
更新日期:1993-12-01 00:00:00
abstract::Proliferating-cell nuclear antigen (PCNA), also known as cyclin, is synthesized in proliferative cells and recently was identified as DNA polymerase-delta auxiliary protein. In this paper, the association of PCNA to the proliferative cells of plants was analysed using both autoantibodies to PCNA obtained from a patien...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290100209
更新日期:1992-06-01 00:00:00
abstract::The time-course of incorporation of NBD-cholesterol by macrophages (Ma) and lymphocytes (LY) obtained from untreated and thioglycollate-injected (thio) rats was investigated. NBD-cholesterol incorporation was also examined in Ma obtained from untreated rats and stimulated in vitro by lipopolysaccharide (LPS) and phorb...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1048
更新日期:2004-01-01 00:00:00
abstract::The activity of glutathione reductase (GHSR) in extracts of kidney, liver and testis of rats infected with Trypanosoma congolense decreased with every wave of parasitemia. The implications of these observations as they relate to the risk of oxidative stress are discussed. ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290130212
更新日期:1995-06-01 00:00:00
abstract::The gene expression of heme oxygenase-1 (HO-1) was studied in mammalian cell lines exposed to hyperoxia. Northern blot analysis demonstrated that hyperoxic exposure increased the HO-1 mRNA levels in various types of cells, including human hepatoma (HepG2) cells. This increase was time- and dose-dependent, and reversib...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199809)16:3<183::AID-CBF78
更新日期:1998-09-01 00:00:00
abstract::The aim of this study was to investigate the possibility of enhancing the yield of tissue plasminogen activator (tPA) from two epithelial cell lines of normal (non-malignant) derivation grown in tissue culture. The three agents used in this investigation were chosen because of their proven enhancing effect on analogou...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290040109
更新日期:1986-01-01 00:00:00
abstract::The influence of the 1,4-dihydropyridines (DHPs), water-soluble glutapyrone available as sodium, potassium and ammonium salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-DHP-4-carboxamide)glutaric acid, from one side, and a lipophylic cerebrocrast, 2-propoxyethyl 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-DHP-3,5-di...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199709)15:3<211::AID-CBF74
更新日期:1997-09-01 00:00:00
abstract::Metabolism of arabinose 5-P, ribose 5-P and glucose 6-P in permeabilized and resealed Morris hepatoma 5123TC cells was investigated by measuring the contribution of these compounds to nucleic acid biosynthesis. The level of [14C]-arabinose (non-phosphorylated) incorporation into nucleic acids was slight, presumably du...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290050408
更新日期:1987-10-01 00:00:00
abstract::Sperm associated antigen 8 (SPAG8), a testis-specific protein produced during male germ cell differentiation, was isolated from a human testis expression library using antibodies found in the serum obtained from an infertile woman. It was found to have a close functional relationship with microtubules. In this study, ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1574
更新日期:2009-07-01 00:00:00
abstract::Deficiency in neutrophils (neutropenia) caused by mutations in neutrophil elastase (NE, ELA2) has been extensively investigated. Monocytes and neutrophils are derived from a common myeloid progenitor; therefore, ELA2 mutations can also influence monocyte development. These effects have not been well described. In this...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2900
更新日期:2013-06-01 00:00:00
abstract::The protective effects of betaine in ethanol hepatotoxicity were investigated in 24 female wistar albino rats. Animals were divided into three groups: control, ethanol and ethanol + betaine group. Animals were fed liquid diets and consumed approximately 60 diet per day. Rats were fed ethanol 8 kg(- 1) day(- 1). The et...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.926
更新日期:2001-12-01 00:00:00
abstract::The aim of this brief communication was to determine the correlation between pre-eclampsia (PE), Helicobacter pylori pathogenic strains seropositivity, and interleukin-18 (IL-18) levels. To this purpose 25 pre-eclamptic women and 25 healthy parturient women of similar age were evaluated for: IL-18 levels, by ELISAH. p...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1503
更新日期:2008-10-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease that is characterized by selective destruction of insulin secreting pancreatic islets beta-cells. The formation of cytokines (IL-1beta, IL-6, TNF-alpha, etc.) leads to extensive morphological damage of beta-cells, DNA fragmentation, decrease of glucos...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1372
更新日期:2007-11-01 00:00:00
abstract::Hyperglycemia induces overproduction of superoxide and it is related to diabetic complications. In this study, we analyzed the antioxidant enzymatic defense and the lipid peroxidation of rat salivary glands in six different periods of diabetic condition. Ninety-six rats were divided into 12 groups: C7/14/21/28/45/60 (...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1683
更新日期:2010-08-01 00:00:00
abstract::Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Me...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1174
更新日期:2005-05-01 00:00:00
abstract::Endothelial dysfunction is recognized as the initial detectable stage of cardiovascular disease, a serious complication of diabetes. In this study, we evaluated effects of myricetin on high glucose (HG)-elicited oxidative damage in human umbilical vein endothelial cells (HUVECs). The cells were pre-incubated with myri...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3442
更新日期:2020-01-01 00:00:00
abstract::Sexually-transmitted diseases (STD) can facilitate the progression of HIV-1 infection. Among them, as we have previously demonstrated, cervico-vaginal dysplasia-papillomavirus (HPV)-induced, together with HSV-2 co-infection, seems to be correlated with a more evident immunodepression in HIV-positive women, compared wi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.950
更新日期:2002-09-01 00:00:00
abstract::The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3058
更新日期:2014-10-01 00:00:00
abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1294
更新日期:2006-11-01 00:00:00
abstract::The effects of either radiation or hyperthermia on the differentiation potential of NG108-15, a neuroblastoma-glioma hybrid cell line, were studied. After radiation and hyperthermia, the outgrowth of neurites from NG108-15 cells was potentiated, and polarizing current and voltage pulses induced a distinct action poten...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290120209
更新日期:1994-06-01 00:00:00
abstract::The aim of the present studies was to determine whether the mechanism of biological action of garlic-derived sulfur compounds in human hepatoma (HepG2) cells can be dependent on the presence of labile sulfane sulfur in their molecules. We investigated the effect of allyl sulfides from garlic: monosulfide, disulfide an...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1835
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Hydrogen peroxide (H(2)O(2)) is a potent reactive oxygen species that causes cardiomyocytes injury. As an important cytokine, interleukin 6 (IL-6) has cardioprotective effects as it plays an essential role in the late phase of preconditioning. Our work is to investigate if IL-6 preconditioning has protective ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2820
更新日期:2012-07-01 00:00:00
abstract::Voltage-gated Ca(2+) channels regulate cardiac automaticity, rhythmicity and excitation-contraction coupling. Whereas L-type (Cav 1·2, Cav 1·3) and T-type (Cav 3·1, Cav 3·2) channels are widely accepted for their functional relevance in the heart, the role of Cav 2·3 Ca(2+) channels expressing R-type currents remains ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2918
更新日期:2013-07-01 00:00:00
abstract::Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signalling pathways including cervical cancer. However, the underlying mechanisms are still not well elucidated. Here, we assessed the effect of silibinin...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1842
更新日期:2012-04-01 00:00:00