Interleukin-18 and gestosis: correlation with Helicobacter pylori seropositivity.

Abstract:

:The aim of this brief communication was to determine the correlation between pre-eclampsia (PE), Helicobacter pylori pathogenic strains seropositivity, and interleukin-18 (IL-18) levels. To this purpose 25 pre-eclamptic women and 25 healthy parturient women of similar age were evaluated for: IL-18 levels, by ELISAH. pylori seropositivity, by anti-IgG ELISAAnti-Cag-A antibodies using a commercial immunoblot assay.We report similar values of IL-18 in our pre-eclamptic patients and in healthy parturient women (respectively 350 +/- 150 vs. 399 +/- 132 pg ml(-1); p = 0.23). However the seropositivity for H. pylori was 84 and 32% (p < 0.001), and anti-Cag-A antibodies were present respectively in 80 and 28% of the two populations. On the basis of our data we hypothesize that H. pylori infection from Cag-A strains can be involved in some cases of PE and that the microorganism could modulate IL-18 release. In fact, differences on IL-18 production have been described by different authors between pre-eclamptic and healthy pregnant women, independently from infective pathology.

journal_name

Cell Biochem Funct

authors

Pugliese A,Beltramo T,Todros T,Cardaropoli S,Ponzetto A

doi

10.1002/cbf.1503

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

817-9

issue

7

eissn

0263-6484

issn

1099-0844

journal_volume

26

pub_type

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