Abstract:
:It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR-2909 has emerged to regulate genes involved in oncogenesis and immunity, the present study was addressed to reveal the nature of miR-2909 expression within cancer cells of different tissue origin and its incorporation into exosomes secreted by these cells. Post-transcriptional modification, especially 3'-end adenylation and uridylation of miR-2909, exerts opposing effects that may contribute to direct its sorting into exosomes secreted by cancer cells. Our study also revealed that selective partitioning of adenosine kinase, between cancer cells and their secreted exosomes, may be responsible for the nature of post-transcriptional modification of miR-2909 observed within these cells.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Wani S,Kaul Ddoi
10.1002/cbf.3323subject
Has Abstractpub_date
2018-03-01 00:00:00pages
106-111issue
2eissn
0263-6484issn
1099-0844journal_volume
36pub_type
杂志文章abstract::Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2973
更新日期:2014-01-01 00:00:00
abstract::The aim of this work was to determine the role of intraperitoneally-administered vitamin E and selenium on the biochemical and haematological parameters in the blood of rats. Thirty-two adult male Wistar rats were used in this study. All rats were randomly divided into four groups. The first group was used as the cont...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199906)17:2<143::AID-CBF80
更新日期:1999-06-01 00:00:00
abstract::Ovarian cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely used in locally advanced ovarian cancer patients. Acquired or de novo cisplatin resistance remains the barrier to patient survival, and the mechanisms of cisplatin resistance are still not well understood. In th...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3319
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of artemisinin on the proliferation and apoptosis of rat vascular smooth muscle cells (VSMCs). METHOD:Primary rat VSMCs were treated with various doses of artemisinin. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2995
更新日期:2014-03-01 00:00:00
abstract::The effects of Alpinia protocatechuic acid (PCA) on spleen and liver antioxidant system in aged rats have been studied. Alpinia PCA, a phenolic compound, was first isolated from the dried fruits of Alpinia Oxyphylla Miq. in our laboratory. Young and aged rats were injected intraperitoneally with Alpinia PCA at single ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1757
更新日期:2011-06-01 00:00:00
abstract::The time-course of incorporation of NBD-cholesterol by macrophages (Ma) and lymphocytes (LY) obtained from untreated and thioglycollate-injected (thio) rats was investigated. NBD-cholesterol incorporation was also examined in Ma obtained from untreated rats and stimulated in vitro by lipopolysaccharide (LPS) and phorb...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1048
更新日期:2004-01-01 00:00:00
abstract::Ceramide is known to trigger apoptosis of nucleated cells and eryptosis of erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Besides ceramide, stimulators of eryptosis include increase of cytosolic Ca(2+) -activity ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3196
更新日期:2016-07-01 00:00:00
abstract::We studied the effect of PTH (10-100 nM) on transductive mechanisms (adenylate cyclase activity, Ca2+ metabolism, IP3 levels) in cell cultures derived from normal and otosclerotic human bone fragments. The cultured cells were osteoblast-like but with calcitonin-receptors still present and with PTH receptors coupled wi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290110406
更新日期:1993-12-01 00:00:00
abstract::In pancreatic islets prepared from fed rats and incubated at a low concentration (1.7 mM) of D-glucose, D-mannoheptulose (10.0 mM) virtually fails to affect the metabolism of the hexose. Likewise, in islets from starved rats, the relative extent of the inhibitory action of D-mannoheptulose upon D-glucose metabolism is...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199903)17:1<65::AID-CBF812
更新日期:1999-03-01 00:00:00
abstract::The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage measure. Indeed, before any investigation on the mechanism of action of different molecules, it is important to perform a cytotoxicity assay. Among the different...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.3135
更新日期:2015-08-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C) is an angiogenic and lymphangiogenic growth factor. Recent research has revealed the role for VEGF-C in regulating autophagy by interacting with a nontyrosine kinase receptor, neuropilin-2 (NRP-2). However, whether VEGF-C participates in regulating cell survival and autoph...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3402
更新日期:2019-06-01 00:00:00
abstract::In moderate physical exercise, the transition from predominantly anaerobic towards predominantly aerobic metabolism is a key step to improve performance. Increase in the supply of oxygen and nutrients, such as free fatty acids (FFA) and glucose, which accompanies high blood flow, is required for this transition. The m...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.1327
更新日期:2006-11-01 00:00:00
abstract::WIN55,212-2, a cannabinoid receptor agonist, can activate cannabinoid receptors, which has proven anti-tumour effects in several tumour types. Studies showed that WIN can inhibit tumour cell proliferation and induce apoptosis in diverse cancers. However, the role and mechanism of WIN in osteosarcoma are still unclear....
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3194
更新日期:2016-07-01 00:00:00
abstract::The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1310
更新日期:2007-07-01 00:00:00
abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1294
更新日期:2006-11-01 00:00:00
abstract::The effect of exposure to, followed by consumption of, 10% flax chow from the 18th day of gestation to the 86th day after birth was examined in male and female Fischer 344 rats. Growth curves of the flax chow-fed rats were identical to those of regular chow-fed rats, as were such developmental milestones as pinna deve...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1058
更新日期:2004-03-01 00:00:00
abstract::This study was designed to investigate the effect of L-carnitine in ischaemia and reperfusion of the rat kidney. Rats were randomly allocated into three groups. Group I (control group; n = 6) received no treatment. Group II (isotonic saline group; n = 6), received 2 ml of isotonic saline 15 min before the renal ischae...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1159
更新日期:2005-05-01 00:00:00
abstract::The object was to determine the influence of dietary vitamin E, selenium and their combination on the fatty acid content of erythrocytes, bone marrow and spleen lipids of Akkaraman lambs. After supplementation for 15 days, the amount of all fatty acids was slightly higher (p < 0.05) in the vitamin E as compared to the...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(199703)15:1<1::AID-CBF694>
更新日期:1997-03-01 00:00:00
abstract::Endothelial dysfunction is recognized as the initial detectable stage of cardiovascular disease, a serious complication of diabetes. In this study, we evaluated effects of myricetin on high glucose (HG)-elicited oxidative damage in human umbilical vein endothelial cells (HUVECs). The cells were pre-incubated with myri...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3442
更新日期:2020-01-01 00:00:00
abstract::Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is consid...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0844(200001/03)18:1<23::AID-CBF
更新日期:2000-03-01 00:00:00
abstract::The new glass ionomer dental cement, ChemFil, was found to be moderately cytotoxic when freshly mixed in vitro. This was assessed by a reduction in fibroblast and macrophage counts following 24 h exposure to the material, and by alterations in enzyme levels and enzyme staining kinetics relative to control cultures. Te...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290020112
更新日期:1984-01-01 00:00:00
abstract::Voltage-gated Ca(2+) channels regulate cardiac automaticity, rhythmicity and excitation-contraction coupling. Whereas L-type (Cav 1·2, Cav 1·3) and T-type (Cav 3·1, Cav 3·2) channels are widely accepted for their functional relevance in the heart, the role of Cav 2·3 Ca(2+) channels expressing R-type currents remains ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2918
更新日期:2013-07-01 00:00:00
abstract::Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti-inflammatory effect of trikatu, a herbal compound in monosodium urate crystal-induced inflammation in rats, an experimental model f...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2979
更新日期:2014-01-01 00:00:00
abstract::Sexually-transmitted diseases (STD) can facilitate the progression of HIV-1 infection. Among them, as we have previously demonstrated, cervico-vaginal dysplasia-papillomavirus (HPV)-induced, together with HSV-2 co-infection, seems to be correlated with a more evident immunodepression in HIV-positive women, compared wi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.950
更新日期:2002-09-01 00:00:00
abstract::Thyroid cells fall into the type of cells functioning during continuous production of high H(2)O(2) concentrations. We studied the effect of H(2)O(2)-induced oxidative stress (0.1, 1.0 and 10.0 mM) on the activities of the key steps of iodide metabolism (uptake, oxidation and organification) in thyrocytes cultivated i...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1452
更新日期:2008-04-01 00:00:00
abstract::The activity of glutathione reductase (GHSR) in extracts of kidney, liver and testis of rats infected with Trypanosoma congolense decreased with every wave of parasitemia. The implications of these observations as they relate to the risk of oxidative stress are discussed. ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.290130212
更新日期:1995-06-01 00:00:00
abstract::The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin c...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3333
更新日期:2018-06-01 00:00:00
abstract::Liver-directed gene therapy has become a promising treatment for many liver diseases. In this study, we constructed a multi-functional targeting molecule, which maintains targeting, endosome-escaping, and DNA-binding abilities for gene delivery. Two single oligonucleotide chains of Melittin (M) were synthesized. The f...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.2958
更新日期:2013-12-01 00:00:00
abstract::We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were rando...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1469
更新日期:2008-06-01 00:00:00
abstract::Glioma is one of the most common brain tumors and one of the most aggressive cancers. Although extensive progress has been made regarding to the diagnosis and treatment, the mortality in glioma patients is still high. Therefore, finding new therapeutic targets to the glioma is critical to the advancement in cancer tre...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.3225
更新日期:2016-10-01 00:00:00