Abstract:
:We studied the effect of PTH (10-100 nM) on transductive mechanisms (adenylate cyclase activity, Ca2+ metabolism, IP3 levels) in cell cultures derived from normal and otosclerotic human bone fragments. The cultured cells were osteoblast-like but with calcitonin-receptors still present and with PTH receptors coupled with the adenylate cyclase system. The results showed that PTH activated adenylate cyclase and increased the intracellular Ca2+ levels with qualitative and quantitative differences between the two cellular populations. In particular, otosclerotic cells responded less to hormone stimulation, which is in accord with the current hypothesis of a desensitization of the receptor/enzyme complex associated with the pathological status.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Fanó G,Venti-Donti G,Belia S,Paludetti G,Antonica A,Donti E,Maurizi Mdoi
10.1002/cbf.290110406subject
Has Abstractpub_date
1993-12-01 00:00:00pages
257-61issue
4eissn
0263-6484issn
1099-0844journal_volume
11pub_type
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