PTH induces modification of transductive events in otosclerotic bone cell cultures.

Abstract:

:We studied the effect of PTH (10-100 nM) on transductive mechanisms (adenylate cyclase activity, Ca2+ metabolism, IP3 levels) in cell cultures derived from normal and otosclerotic human bone fragments. The cultured cells were osteoblast-like but with calcitonin-receptors still present and with PTH receptors coupled with the adenylate cyclase system. The results showed that PTH activated adenylate cyclase and increased the intracellular Ca2+ levels with qualitative and quantitative differences between the two cellular populations. In particular, otosclerotic cells responded less to hormone stimulation, which is in accord with the current hypothesis of a desensitization of the receptor/enzyme complex associated with the pathological status.

journal_name

Cell Biochem Funct

authors

Fanó G,Venti-Donti G,Belia S,Paludetti G,Antonica A,Donti E,Maurizi M

doi

10.1002/cbf.290110406

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

257-61

issue

4

eissn

0263-6484

issn

1099-0844

journal_volume

11

pub_type

杂志文章
  • Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats.

    abstract::Cyclophosphamide (CP) has potential urotoxicity such as hemorrhagic cystitis (HC). 2-Mercaptoethane sulfonate (mesna) has been widely used as an effective agent against CP-induced cystitis, but significant HC has still been encountered clinically. In recent studies, mesna was shown to be more effective if combined wit...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1347

    authors: Sadir S,Deveci S,Korkmaz A,Oter S

    更新日期:2007-09-01 00:00:00

  • Gender depended potentiality of differentiation of human umbilical cord mesenchymal stem cells into oocyte-Like cells in vitro.

    abstract::Recent studies have demonstrated that germ-like cells could be differentiated from human umbilical cord mesenchymal stem cells (hUC-MSCs) in vitro. Whether the sexuality of hUC-MSCs affects the formation efficiency of germ-like cells derived from hUC-MSCs is still unclear. To clearly test the formation efficiency of o...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2981

    authors: Qiu P,Bai Y,Pan S,Li W,Liu W,Hua J

    更新日期:2013-07-01 00:00:00

  • Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer.

    abstract::The effects of 1,25-dihydroxyvitamin D3 are mediated by binding to a specific intracellular vitamin D receptor (VDR), which has been identified in a variety of tissues. Certain polymorphisms in the VDR gene have been associated with various neoplasms. For this purpose, we studied whether VDR TaqI or FokI genotype are ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1386

    authors: Yaylim-Eraltan I,Arzu Ergen H,Arikan S,Okay E,Oztürk O,Bayrak S,Isbir T

    更新日期:2007-11-01 00:00:00

  • Regulation of the G2/M phase of the cell cycle by sperm associated antigen 8 (SPAG8) protein.

    abstract::Sperm associated antigen 8 (SPAG8), a testis-specific protein produced during male germ cell differentiation, was isolated from a human testis expression library using antibodies found in the serum obtained from an infertile woman. It was found to have a close functional relationship with microtubules. In this study, ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1574

    authors: Li R,Tang XL,Miao SY,Zong SD,Wang LF

    更新日期:2009-07-01 00:00:00

  • Effects of intraperitoneally-administered vitamin E and selenium on the blood biochemical and haematological parameters in rats.

    abstract::The aim of this work was to determine the role of intraperitoneally-administered vitamin E and selenium on the biochemical and haematological parameters in the blood of rats. Thirty-two adult male Wistar rats were used in this study. All rats were randomly divided into four groups. The first group was used as the cont...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0844(199906)17:2<143::AID-CBF80

    authors: Cay M,Naziroğlu M

    更新日期:1999-06-01 00:00:00

  • Ceranib-2-induced suicidal erythrocyte death.

    abstract::Ceramide is known to trigger apoptosis of nucleated cells and eryptosis of erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Besides ceramide, stimulators of eryptosis include increase of cytosolic Ca(2+) -activity ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3196

    authors: Signoretto E,Zierle J,Bhuyan AA,Castagna M,Lang F

    更新日期:2016-07-01 00:00:00

  • Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert-butyl hydroperoxide-induced erythrocyte haemolysis.

    abstract::Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2933

    authors: Adesanoye OA,Molehin OR,Delima AA,Adefegha AS,Farombi EO

    更新日期:2013-10-01 00:00:00

  • A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment.

    abstract::Cardiovascular diseases are known to be the most fatal diseases worldwide. Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common cardiovascular diseases. According to the World Health Organization estimates, ischaemic heart disease is the leading global cause of death, causing more th...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章,评审

    doi:10.1002/cbf.3587

    authors: Gunata M,Parlakpinar H

    更新日期:2020-09-06 00:00:00

  • The study of renin-angiotensin-aldosterone in experimental diabetes mellitus.

    abstract::It is generally accepted that hypertension and other vascular pathologies increase in diabetes mellitus (DM) patients as a result of the renin-angiotensin-aldosterone (RAA) system. In this study, changes in the renin-angiotensin-aldosterone (RAA) system level was determined in Streptozotocin (STZ)-injected rats. A tot...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0844(199909)17:3<193::AID-CBF82

    authors: Ustündag B,Cay M,Naziroglu M,Dilsiz N,Crabbe MJ,Ilhan N

    更新日期:1999-09-01 00:00:00

  • The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.

    abstract::This study was designed to investigate the role of HO-1 induction in prevention of thioacetamide (TAA)-induced oxidative stress, inflammation and liver damage. The changes in hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well as plasma arginine and asymmetric dimethylarginine (ADMA) levels were al...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2866

    authors: Develi-Is S,Bekpinar S,Kalaz EB,Evran B,Unlucerci Y,Gulluoglu M,Uysal M

    更新日期:2013-03-01 00:00:00

  • Post-translational modifications of protein in response to ionizing radiation.

    abstract::Based on central dogma of genetics, protein is the embodiment and executor of genetic function, post-translational modifications (PTMs) of protein are particularly important and involved in almost all aspects of cell biology and pathogenesis. Studies have shown that ionizing radiation (IR) alters gene expression much ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章,评审

    doi:10.1002/cbf.3467

    authors: Liu X,Liu R,Bai Y,Jiang H,Fu X,Ma S

    更新日期:2020-04-01 00:00:00

  • Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil.

    abstract::The use of Nigerian bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders, burns, foot ulcers and reproductive capacity is a common practice in the southern part of Nigeria. Towards understanding the mechanism and the reversibility of hepatotoxicity induced by BLCO, adult male Wistar rats were or...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2823

    authors: Adedara IA,Farombi EO

    更新日期:2012-08-01 00:00:00

  • Localization of biotransformational enzymes along the crypt-villus axis of the rat intestine. Evaluation of two cell isolation procedures.

    abstract::Rat intestinal epithelial cells were isolated by EDTA-chelation, combined with gentle shaking (modified Weiser procedure) or with strong longitudinal vibration (Harrison/Webster procedure). Both methods yield large numbers of viable cells and are relatively easy to use. Electronmicroscopical and biochemical data indic...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290020208

    authors: Koster AS,Borm PJ,Dohmen MR,Noordhoek J

    更新日期:1984-04-01 00:00:00

  • Subcellular localization of recently-absorbed iron in mouse duodenal enterocytes: identification of a basolateral membrane iron-binding site.

    abstract::The subcellular distribution of newly absorbed iron in isolated mouse duodenal enterocytes was investigated by analytical subcellular fractionation using sucrose density gradient centifugation. Two major peaks of mucosal 59Fe activity were observed: one soluble and one particulate (density 1.18-1.20 g ml-1). The latte...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290080205

    authors: Snape S,Simpson RJ,Peters TJ

    更新日期:1990-04-01 00:00:00

  • The effect of taurine supplementation on oxidative stress in experimental hypothyroidism.

    abstract::The purpose of this study was to investigate the oxidative status in experimental hypothyroidism and the antioxidant effect of taurine supplementation. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + taurine; group 3, propylthiouracil (PTU); group 4, PTU + ta...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1198

    authors: Taş S,Dirican M,Sarandöl E,Serdar Z

    更新日期:2006-03-01 00:00:00

  • Inositol lipid phosphorylation and breakdown in rat liver nuclei is affected by hydrocortisone blood levels.

    abstract::The possibility that inositol lipid metabolism is related to nuclear events accompanying steroid hormone action has been investigated by comparing lipid phosphorylation and breakdown in normal rat liver nuclei and in hypo- and hypercortisolemic conditions. Lipid phosphorylation in vitro showed the presence of diacylgl...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290120308

    authors: Santi P,Marmiroli S,Falcieri E,Bertagnolo V,Capitani S

    更新日期:1994-09-01 00:00:00

  • Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.

    abstract::The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulati...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2905

    authors: Yang Y,Wolfram J,Boom K,Fang X,Shen H,Ferrari M

    更新日期:2013-07-01 00:00:00

  • Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise.

    abstract::In moderate physical exercise, the transition from predominantly anaerobic towards predominantly aerobic metabolism is a key step to improve performance. Increase in the supply of oxygen and nutrients, such as free fatty acids (FFA) and glucose, which accompanies high blood flow, is required for this transition. The m...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章,评审

    doi:10.1002/cbf.1327

    authors: Hirabara SM,Silveira LR,Abdulkader FR,Alberici LC,Procopio J,Carvalho CR,Pithon-Curi TC,Curi R

    更新日期:2006-11-01 00:00:00

  • Adaptation to phosphate deprivation in osteoblast-like cells.

    abstract::The rat osteosarcoma cell line UMR-106-01 has an osteoblast-like phenotype. When grown in monolayer culture these cells transport inorganic phosphate and L-alanine via Na(+)-dependent transport systems. Exposure of these cells to a low phosphate medium for 4 h produced a 60-70 per cent increase in Na(+)-dependent phos...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290110207

    authors: Ha R,Steenbergen DK,Kempson SA

    更新日期:1993-06-01 00:00:00

  • Effect of glucosphingolipid synthesis inhibitor (PPMP and PDMP) treatment on Tetrahymena pyriformis: data on the evolution of the signaling system.

    abstract::1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and 1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) are structural analogues of ceramide; inhibiting UDP-glucose : ceramide glucosyltransferase. After treatment with these synthetic ceramide analogues the expression of glucosphingolipid decreases, while ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/1099-0844(200012)18:4<269::AID-CBF883>3.0.

    authors: Kovács P,Pintér M,Csaba G

    更新日期:2000-12-01 00:00:00

  • Ca2+ responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization.

    abstract::The molecular mechanisms involved in GPCR-initiated signaling cascades where the two receptors share the same signaling cascade, such as thyrotropin-releasing hormone (TRH) and angiotensin II (ANG II), are still far from being understood. Here, we analyzed hormone-induced Ca(2+) responses and the process of desensitiz...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1453

    authors: Ostasov P,Krusek J,Durchankova D,Svoboda P,Novotny J

    更新日期:2008-03-01 00:00:00

  • Anti-ageing effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice.

    abstract::The effects of Alpinia protocatechuic acid (PCA) on spleen and liver antioxidant system in aged rats have been studied. Alpinia PCA, a phenolic compound, was first isolated from the dried fruits of Alpinia Oxyphylla Miq. in our laboratory. Young and aged rats were injected intraperitoneally with Alpinia PCA at single ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1757

    authors: Zhang X,Shi GF,Liu XZ,An LJ,Guan S

    更新日期:2011-06-01 00:00:00

  • In vivo evidence suggesting a role for purine-catabolizing enzymes in the pathogenesis of cisplatin-induced nephrotoxicity in rats and effect of erdosteine against this toxicity.

    abstract::The aim of this experimental study was to investigate the possible role of adenosine deaminase (AD) and xanthine oxidase (XO) in the pathogenesis of cisplatin-induced nephrotoxicity and the effect of erdosteine in decreasing the toxicity. The intraperitoneal injection of cisplatin (7 mg kg(-1) body weight) induced a s...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1069

    authors: Söğüt S,Kotuk M,Yilmaz HR,Ulu R,Ozyurt H,Yildirim Z

    更新日期:2004-05-01 00:00:00

  • Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6.

    abstract::Bisphenol A (BPA) can be accumulated into the human body via food intake and inhalation. Numerous studies indicated that BPA can trigger the tumorigenesis and progression of cancer cells. Laryngeal cancer cells can be exposed to BPA directly via food digestion, while there were very limited data concerning the effect ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3265

    authors: Li S,Wang B,Tang Q,Liu J,Yang X

    更新日期:2017-06-01 00:00:00

  • Modulation of gastrin-releasing peptide (GRP) receptors in insulin secreting cells.

    abstract::Gastrin-releasing peptide (GRP) receptors are present in pancreatic islets, though their regulation is unknown except for homologous desensitization. The modulation of binding of GRP to mouse pancreatic islets and INS-1 cells was studied. At 60 min (steady-state), total binding of [(125)I-Tyr(15)] GRP was 1.62 per cen...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0844(199912)17:4<229::AID-CBF83

    authors: Kloss H,Wahl MA,Neye H,Verspohl EJ

    更新日期:1999-12-01 00:00:00

  • The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats.

    abstract::We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were rando...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1469

    authors: Kavak S,Ayaz L,Emre M,Inal T,Tamer L,Günay I

    更新日期:2008-06-01 00:00:00

  • Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits.

    abstract::The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.976

    authors: Irmak MK,Fadillioğlu E,Güleç M,Erdoğan H,Yağmurca M,Akyol O

    更新日期:2002-12-01 00:00:00

  • Spermidine promotes melanin production through an MITF signalling pathway.

    abstract::Melanin plays an important role in determining skin colour. Apoptosis of melanocytes and defect in melanin production cause vitiligo. Various studies have been conducted to treat the disease, but its treatment is still difficult. Therefore, this study aimed to investigate the effect of spermidine, which is known as an...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3619

    authors: Kang SH,Kim MM

    更新日期:2021-01-25 00:00:00

  • Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231).

    abstract::Epidermal growth factor plays a major role in breast cancer cell proliferation, survival, and metastasis. Quercetin, a bioactive flavonoid, is shown to exhibit anticarcinogenic effects against various cancers including breast cancer. Hence, the present study was designed to evaluate the effects of gold nanoparticles-c...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3266

    authors: Balakrishnan S,Mukherjee S,Das S,Bhat FA,Raja Singh P,Patra CR,Arunakaran J

    更新日期:2017-06-01 00:00:00

  • Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats.

    abstract::Indoleamine 2,3-dioxygenase (IDO) converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, to investigate the effects of IDO in carbon tetrachloride (CCl(4) )-induced hepatitis model, the levels of IDO enzymic activities in the...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2803

    authors: Li D,Cai H,Hou M,Fu D,Ma Y,Luo Q,Yuan X,Lv M,Zhang X,Cong X,Lv Z

    更新日期:2012-06-01 00:00:00