Abstract:
:Retinopathy of prematurity, a leading cause of visual impairment in low birth-weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. Ciliary neurotrophic factor expression is regulated by many factors such as all-trans retinoic acid (ATRA). In this study, we found that ATRA increased CNTF expression in mouse retinal pigment epithelial (RPE) cells in a dose- and time-dependent manner, and PKA signaling pathway is necessary for ATRA-induced CNTF upregulation. Furthermore, we showed that ATRA promoted CNTF expression through CREB binding to its promoter region. In addition, CNTF levels were decreased in serum of retinopathy of prematurity children and in retinal tissue of oxygen-induced retinopathy mice. In mouse RPE cells cultured with high oxygen, CNTF expression and secretion were decreased, but could be recovered after treatment with ATRA. In conclusion, our data suggest that ATRA administration upregulates CNTF expression in RPE cells.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Zhou WD,Wang LL,Zhou LB,Bin W,Bao TP,Zhang Y,Shu J,Yang WX,Hui LL,Jin R,Zhuang LL,Zhou GPdoi
10.1002/cbf.3264subject
Has Abstractpub_date
2017-06-01 00:00:00pages
202-208issue
4eissn
0263-6484issn
1099-0844journal_volume
35pub_type
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