Abstract:
:Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in patients with FMF who suffer from renal disease. Renal biopsies obtained from two patients who were diagnosed with FMF renal disease complications were examined. Examination of renal tissue by light and electron microscopy identified degenerations both in tubules and the filtration barrier. Foot processes were partly effaced. Amorphous material was found in thickened glomerular basement membranes. Fibrous material deposits in thick Bowman's capsule wall were also seen. Finally, degeneration in the form of folding of plasma membrane and vacuolization as well as fusion in mitochondria cristae, was observed. Accumulation of tissue remnants in the lumen was also found in tubules.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Kiliçaslan SM,Ayvali C,Taştan Hdoi
10.1002/cbf.1286subject
Has Abstractpub_date
2007-07-01 00:00:00pages
363-7issue
4eissn
0263-6484issn
1099-0844journal_volume
25pub_type
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