High-fat diet and hydrochlorothiazide increase oxidative stress in brain of rats.

Abstract:

:This study evaluated the effect of possible synergic interaction between high fat diet (HF) and hydrochlorothiazide (HCTZ) on biochemical parameters of oxidative stress in brain. Rats were fed for 16 weeks with a control diet or with an HF, both supplemented with different doses of HCTZ (0.4, 1.0, and 4.0 g kg(-1) of diet). HF associated with HCTZ caused a significant increase in lipid peroxidation and blood glucose levels. In addition, HF ingestion was associated with an increase in cerebral lipid peroxidation, vitamin C and non-protein thiol groups (NPSH) levels. There was an increase in vitamin C as well as NPSH levels in HCTZ (1.0 and 4.0 g kg(-1) of diet) and HF plus HCTZ groups. Na(+)-K(+)-ATPase activity of HCTZ (4.0 g kg(-1) of diet) and HCTZ plus HF-fed animals was significantly inhibited. Our data indicate that chronic intake of a high dose of HCTZ (4 g kg(-1) of diet) or HF change biochemical indexes of oxidative stress in rat brain. Furthermore, high-fat diets consumption and HCTZ treatment have interactive effects on brain, showing that a long-term intake of high-fat diets can aggravate the toxicity of HCTZ.

journal_name

Cell Biochem Funct

authors

Ribeiro MC,Barbosa NB,de Almeida TM,Parcianello LM,Perottoni J,de Avila DS,Rocha JB

doi

10.1002/cbf.1599

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

473-8

issue

7

eissn

0263-6484

issn

1099-0844

journal_volume

27

pub_type

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