Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells.

abstract：:Functional irregularities due to damage after ischaemia-reperfusion vary depending upon the organs affected. High energy phosphates such as ATP and ADP are destroyed after ischaemia-reperfusion damage. Subsequently, protons and inorganic phosphates accumulate within the cells and the proton pumps such as adenosine tri...

journal_title：Cell biochemistry and function

authors： Ilhan N,Halifeoglu I,Ozercan HI,Ilhan N

更新日期：2001-09-01 00:00:00

abstract：:The object was to determine the influence of dietary vitamin E, selenium and their combination on the fatty acid content of erythrocytes, bone marrow and spleen lipids of Akkaraman lambs. After supplementation for 15 days, the amount of all fatty acids was slightly higher (p < 0.05) in the vitamin E as compared to the...

journal_title：Cell biochemistry and function

authors： Yilmaz O,Celik S,Naziroğlu M,Cay M,Dilsiz N

更新日期：1997-03-01 00:00:00

abstract：:The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin c...

journal_title：Cell biochemistry and function

authors： Nephan G,Coskun ZM,Bolkent S

更新日期：2018-06-01 00:00:00

abstract：:Regulation of extracellular matrix (ECM) components is essential for tissue homeostasis and function. We screened a small peptide that induces ECM protein synthesis for its usefulness in protecting keratinocytes. In this report, we demonstrate that myristoyl tetrapeptide Ala-Ala-Pro-Val (mAAPV) stimulates the expressi...

journal_title：Cell biochemistry and function

authors： Kwon H,Lee YS,Kim MO,Chang MY,Won BM,Jin BS,Park S

更新日期：2014-12-01 00:00:00

abstract：:Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in p...

journal_title：Cell biochemistry and function

authors： Kiliçaslan SM,Ayvali C,Taştan H

更新日期：2007-07-01 00:00:00

abstract：:The effects of Alpinia protocatechuic acid (PCA) on spleen and liver antioxidant system in aged rats have been studied. Alpinia PCA, a phenolic compound, was first isolated from the dried fruits of Alpinia Oxyphylla Miq. in our laboratory. Young and aged rats were injected intraperitoneally with Alpinia PCA at single ...

journal_title：Cell biochemistry and function

authors： Zhang X,Shi GF,Liu XZ,An LJ,Guan S

更新日期：2011-06-01 00:00:00

abstract：:Sexually-transmitted diseases (STD) can facilitate the progression of HIV-1 infection. Among them, as we have previously demonstrated, cervico-vaginal dysplasia-papillomavirus (HPV)-induced, together with HSV-2 co-infection, seems to be correlated with a more evident immunodepression in HIV-positive women, compared wi...

journal_title：Cell biochemistry and function

authors： Pugliese A,Andronico L,Gennero L,Pagliano G,Gallo G,Torre D

更新日期：2002-09-01 00:00:00

abstract：:MicroRNA (miRNAs) are short non-coding RNA molecules that downregulate gene expression at post-transcriptional level. miRNAs are post-transcriptional regulators of gene expression important for neuron development and function. This report demonstrated that a putative and chemically synthesized miRNA rno-mir-541 played...

journal_title：Cell biochemistry and function

authors： Zhang J,Zhang J,Liu LH,Zhou Y,Li YP,Shao ZH,Wu YJ,Li MJ,Fan YY,Shi HJ

更新日期：2011-06-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a common complication of premature birth that seriously affects the survival rate and quality of life among preterm neonates. Long non-coding RNAs (lncRNAs) have been implicated in many human diseases. However, the role of lncRNAs in the pathogenesis of BPD remains poorly understood...

journal_title：Cell biochemistry and function

authors： Bao TP,Wu R,Cheng HP,Cui XW,Tian ZF

更新日期：2016-07-01 00:00:00

abstract：:The effect of citrinin on Ca2+ transport was studied in isolated kidney cortex and liver mitochondria, and baby hamster kidney cultured cells. The mycotoxin significantly inhibited the activity of 2-oxoglutarate and pyruvate dehydrogenases in both kidney cortex and liver mitochondria. Citrinin promoted a decrease in t...

journal_title：Cell biochemistry and function

authors： Chagas GM,Oliveira MA,Campello AP,Kluppel ML

更新日期：1995-03-01 00:00:00

abstract：:It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR-2909 has emerged to regulate genes involve...

journal_title：Cell biochemistry and function

authors： Wani S,Kaul D

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present work was to investigate the mechanisms of oxidative damage of the liver mitochondria under diabetes and intoxication in rats as well as to evaluate the possibility of corrections of mitochondrial disorders by pharmacological doses of melatonin. The experimental (30 days) streptozotocin-induced d...

journal_title：Cell biochemistry and function

authors： Cheshchevik VT,Dremza IK,Lapshina EA,Zabrodskaya SV,Kujawa J,Zavodnik IB

更新日期：2011-08-01 00:00:00

abstract：:Diabetes induces oxidative stress in aged human and rat, although daily supplementation of vitamins C and E (VCE) can be beneficial to aged diabetic rats by reducing free radical production. The aim of the present study was to evaluate whether dietary VCE supplementation relieves oxidative stress in streptozotocin (ST...

journal_title：Cell biochemistry and function

authors： Özkaya D,Naziroğlu M,Armağan A,Demirel A,Köroglu BK,Çolakoğlu N,Kükner A,Sönmez TT

更新日期：2011-06-01 00:00:00

abstract：:The new glass ionomer dental cement, ChemFil, was found to be moderately cytotoxic when freshly mixed in vitro. This was assessed by a reduction in fibroblast and macrophage counts following 24 h exposure to the material, and by alterations in enzyme levels and enzyme staining kinetics relative to control cultures. Te...

journal_title：Cell biochemistry and function

authors： Meryon SD,Browne RM

更新日期：1984-01-01 00:00:00

abstract：:The effects of several novel monosaccharides upon thymidine incorporation into both normal and tumour cells were investigated. The monosaccharide 2-deoxy-3-[1-(R)-(ethoxycarbonyl)ethyl]- alpha-D-allo-pyranose had the most inhibitory effect on proliferation, with the (S)-enantiomer having less inhibitory effects. The c...

journal_title：Cell biochemistry and function

authors： Colquhoun A,Alaluf S,Bradley A,Gemmell N,Gibbs G,Osborn HM,Harwood LM,Newsholme EA

更新日期：1997-12-01 00:00:00

abstract：:The use of Nigerian bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders, burns, foot ulcers and reproductive capacity is a common practice in the southern part of Nigeria. Towards understanding the mechanism and the reversibility of hepatotoxicity induced by BLCO, adult male Wistar rats were or...

journal_title：Cell biochemistry and function

authors： Adedara IA,Farombi EO

更新日期：2012-08-01 00:00:00

abstract：:The main purpose of the present investigation was to study the effect of cloturin on aerobic glycolysis, endogenous and exogenous respiration and the level of ATP in both Ehrlich ascites carcinoma (EAC) and P388 murine leukaemia cells incubated in vitro. Also its effect on the level of total (T-SH) and non-protein (NP...

journal_title：Cell biochemistry and function

authors： Miko M,Krepelka J,Melka M

更新日期：1992-06-01 00:00:00

abstract：:Mitochondrial, endoplasmic reticular and plasma membrane fractions were isolated by a new method from control male Fischer 344 rats and rats given CCl4 by gavage. After 1 h of CCl4 treatment, rats were in glucose and pancreatic hormone balance but plasma levels of T3 and T4 were decreased 29 and 22%, respectively. Aft...

journal_title：Cell biochemistry and function

authors： Hemmings SJ,Pulga VB,Tran ST,Uwiera RR

更新日期：2002-03-01 00:00:00

abstract：:The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This ...

journal_title：Cell biochemistry and function

authors： Irmak MK,Fadillioğlu E,Güleç M,Erdoğan H,Yağmurca M,Akyol O

更新日期：2002-12-01 00:00:00

abstract：:Cardiovascular diseases are known to be the most fatal diseases worldwide. Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common cardiovascular diseases. According to the World Health Organization estimates, ischaemic heart disease is the leading global cause of death, causing more th...

journal_title：Cell biochemistry and function

authors： Gunata M,Parlakpinar H

更新日期：2020-09-06 00:00:00

abstract：:Although techniques for purifying epidermal stem cells (ESCs) have been established, enriching a pure population of viable ESCs is still a challenging task. One approach toward enhancing the purity and viability of ESCs involves cell markers. While evidence suggests that p63 plays a role in maintaining the population ...

journal_title：Cell biochemistry and function

authors： Tao Q,Qiao B,Lv B,Zheng C,Chen Z,Huang H

更新日期：2009-12-01 00:00:00

abstract：:The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower costs and/or increase efficacies for using BMP-2. In this study, we de...

journal_title：Cell biochemistry and function

authors： Okada M,Sangadala S,Liu Y,Yoshida M,Reddy BV,Titus L,Boden SD

更新日期：2009-12-01 00:00:00

abstract：:Glucocorticoids are important for skeletal muscle energy metabolism, regulating glucose utilization, insulin sensitivity, and muscle mass. Nicotinamide adenine dinucleotide phosphate-dependent 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)-mediated glucocorticoid activation in the sarcoplasmic reticulum (SR) is in...

journal_title：Cell biochemistry and function

authors： Zielinska AE,Fletcher RS,Sherlock M,Doig CL,Lavery GG

更新日期：2017-07-01 00:00:00

abstract：:The p53 protein plays a critical role in suppression of tumour growth; its regulation is not fully understood. Leukaemia/lymphoma-related factor (LRF) promotes tumour cell growth. This study tests a hypothesis that LRF inhibits p53 expression in colon cancer cells. In this study, human colon cancer cell lines, LIM1215...

journal_title：Cell biochemistry and function

authors： Zhu M,Wang P,Feng F,Li MY

更新日期：2017-10-01 00:00:00

abstract：:It is generally accepted that hypertension and other vascular pathologies increase in diabetes mellitus (DM) patients as a result of the renin-angiotensin-aldosterone (RAA) system. In this study, changes in the renin-angiotensin-aldosterone (RAA) system level was determined in Streptozotocin (STZ)-injected rats. A tot...

journal_title：Cell biochemistry and function

authors： Ustündag B,Cay M,Naziroglu M,Dilsiz N,Crabbe MJ,Ilhan N

更新日期：1999-09-01 00:00:00

abstract：:The microsomes from dehydroepiandrosterone (DHEA)-supplemented animals are good hydroxyl radical scavengers, as demonstrated through electron spin resonance and deoxyribose degradation. The ability of DHEA-supplemented microsomes to react with superoxide radical was also demonstrated through the inhibition of nitroblu...

journal_title：Cell biochemistry and function

authors： Tamagno E,Aragno M,Boccuzzi G,Gallo M,Parola S,Fubini B,Poli G,Danni O

更新日期：1998-03-01 00:00:00

abstract：:Because of limited treatment options, preeclampsia (PE) is the leading cause of perinatal morbidity and mortality worldwide. Recently, lncRNA TDRG1 is reported to be aberrantly down-regulated in PE placenta, and the abnormal expression of TDRG1 might play a key or partial role in PE development. In this study, we foun...

journal_title：Cell biochemistry and function

authors： Gong F,Cheng H,Shi Y,Cui L,Jia G

更新日期：2020-06-01 00:00:00

abstract：:Ras-GTPases regulate many central signalling pathways in the cell. Hypoxia induces nitrosative/oxidative stress and dysregulates Ras-dependent downstream processes. H-Ras possesses two cysteine residues (C181 and C184) in the C-termini, which are palmitoylated once or twice. Palmitoylation is sufficient for promoting ...

journal_title：Cell biochemistry and function

authors： Goloshvili G,Barbakadze T,Mikeladze D

更新日期：2019-10-01 00:00:00

abstract：:The consumption of protein supplements containing amino acids is increasing around the world. Aspartate (Asp) and asparagine (Asn) are amino acids metabolized by skeletal muscle. This metabolism involves biochemical pathways that are involved in increasing Krebs cycle activity via anaplerotic reactions, resulting in h...

journal_title：Cell biochemistry and function

authors： Lancha AH Jr,Poortmans JR,Pereira LO

更新日期：2009-12-01 00:00:00

abstract：:Retinopathy of prematurity, a leading cause of visual impairment in low birth-weight infants, remains a crucial therapeutic challenge. Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that promotes rod and cone photoreceptor survival and cone outer segment regeneration in the degenerating retina. ...

journal_title：Cell biochemistry and function

authors： Zhou WD,Wang LL,Zhou LB,Bin W,Bao TP,Zhang Y,Shu J,Yang WX,Hui LL,Jin R,Zhuang LL,Zhou GP

更新日期：2017-06-01 00:00:00