Stimulation of human platelets with concanavalin A involves phospholipase C activation.

abstract：:Sperm associated antigen 8 (SPAG8), a testis-specific protein produced during male germ cell differentiation, was isolated from a human testis expression library using antibodies found in the serum obtained from an infertile woman. It was found to have a close functional relationship with microtubules. In this study, ...

journal_title：Cell biochemistry and function

authors： Li R,Tang XL,Miao SY,Zong SD,Wang LF

更新日期：2009-07-01 00:00:00

abstract：:A method for the quantification of energy consuming processes described by Siems et al. for reticulocytes and by Müller et al. for ascites tumour cells was applied to balance the ATP-consumption of isolated rat hepatocytes. On the basis of decreased coupled respiration rates following the specific inhibition of energy...

journal_title：Cell biochemistry and function

authors： Schneider W,Siems W,Grune T

更新日期：1990-10-01 00:00:00

abstract：:Although techniques for purifying epidermal stem cells (ESCs) have been established, enriching a pure population of viable ESCs is still a challenging task. One approach toward enhancing the purity and viability of ESCs involves cell markers. While evidence suggests that p63 plays a role in maintaining the population ...

journal_title：Cell biochemistry and function

authors： Tao Q,Qiao B,Lv B,Zheng C,Chen Z,Huang H

更新日期：2009-12-01 00:00:00

abstract：:Ras-GTPases regulate many central signalling pathways in the cell. Hypoxia induces nitrosative/oxidative stress and dysregulates Ras-dependent downstream processes. H-Ras possesses two cysteine residues (C181 and C184) in the C-termini, which are palmitoylated once or twice. Palmitoylation is sufficient for promoting ...

journal_title：Cell biochemistry and function

authors： Goloshvili G,Barbakadze T,Mikeladze D

更新日期：2019-10-01 00:00:00

abstract：:Corneal scarring is the result of a disease, infection or injury. The resulting scars cause significant loss of vision or even blindness. To-date, the most successful treatment is corneal transplantation, but it does not come without side effects. One of the corneal dystrophies that are correlated with corneal scarrin...

journal_title：Cell biochemistry and function

authors： McKay TB,Sarker-Nag A,Lyon D,Asara JM,Karamichos D

更新日期：2015-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, to investigate the effects of IDO in carbon tetrachloride (CCl(4) )-induced hepatitis model, the levels of IDO enzymic activities in the...

journal_title：Cell biochemistry and function

authors： Li D,Cai H,Hou M,Fu D,Ma Y,Luo Q,Yuan X,Lv M,Zhang X,Cong X,Lv Z

更新日期：2012-06-01 00:00:00

abstract：:The molecular mechanisms involved in GPCR-initiated signaling cascades where the two receptors share the same signaling cascade, such as thyrotropin-releasing hormone (TRH) and angiotensin II (ANG II), are still far from being understood. Here, we analyzed hormone-induced Ca(2+) responses and the process of desensitiz...

journal_title：Cell biochemistry and function

authors： Ostasov P,Krusek J,Durchankova D,Svoboda P,Novotny J

更新日期：2008-03-01 00:00:00

abstract：:Glaucoma is optic neuropathy that is characterized by progressive neurodegeneration of the retinal ganglion cells (RGCs) and axons. This condition will lead to visual impairment and bring glaucoma to become the second cause of blindness globally. Neuroprotection in glaucoma is needed to prevent the progression of opti...

journal_title：Cell biochemistry and function

authors： Ko JA,Komatsu K,Okumichi H,Kiuchi Y

更新日期：2021-01-01 00:00:00

abstract：:The modification of myeloperoxidase and lactoperoxidase with 2-(O-methoxypolethylene glycol)-4, 6-dichloro-s-triazine, an activated polyethylene glycol (PEG1), was investigated. The modification caused a shift of the Soret band in the light absorption spectrum, from 430 nm to 418 nm in the case of myeloperoxidase (nat...

journal_title：Cell biochemistry and function

authors： Odajima T,Onishi M

更新日期：1998-06-01 00:00:00

abstract：:The MCF-7 human breast carcinoma cell line is widely used as a model system by breast cancer researchers and cell biologists investigating apoptosis. Since its establishment 30 years ago, from a patient with metastatic breast cancer, the original MCF-7 cell population has undergone genetic drift to such an extent that...

journal_title：Cell biochemistry and function

authors： Rintala-Maki ND,Abrasonis V,Burd M,Sutherland LC

更新日期：2004-09-01 00:00:00

abstract：:This study was designed to investigate the role of HO-1 induction in prevention of thioacetamide (TAA)-induced oxidative stress, inflammation and liver damage. The changes in hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well as plasma arginine and asymmetric dimethylarginine (ADMA) levels were al...

journal_title：Cell biochemistry and function

authors： Develi-Is S,Bekpinar S,Kalaz EB,Evran B,Unlucerci Y,Gulluoglu M,Uysal M

更新日期：2013-03-01 00:00:00

abstract：:The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose...

journal_title：Cell biochemistry and function

authors： Pitsillides AA,Blake SM,Glynn LE,Bitensky L,Chayen J

更新日期：1990-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties ...

journal_title：Cell biochemistry and function

authors： Adesanoye OA,Molehin OR,Delima AA,Adefegha AS,Farombi EO

更新日期：2013-10-01 00:00:00

abstract：:Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on biochemical and hematologic...

journal_title：Cell biochemistry and function

authors： dos Santos Lacerda D,de Oliveira Castro V,Mascarenhas M,Guerra RB,Dani C,Coitinho A,Gomez R,Funchal C

更新日期：2012-06-01 00:00:00

abstract：:Reduced and oxidized glutathione (GSH and GSSG), protein-bound glutathione, lipid peroxidation and antioxidant enzyme activities were determined in the erythrocyte lysates and membranes of type I and II alcoholics in order to clarify the effect of age-of-onset and the duration of the alcohol consumption on erythrocyte...

journal_title：Cell biochemistry and function

authors： Uçar G,Demir B,Uluğ B

更新日期：2005-01-01 00:00:00

abstract：:To determine the temporal roles of phosphatidylinositol 3-kinase (PI3-kinase) and phospholipase D (PLD) during human neutrophil activation stimulated by a chemotactic peptide, we examined the kinetics of these enzymes and related them to a neutrophil function (superoxide production). Both wortmannin and 2-(4-morpholin...

journal_title：Cell biochemistry and function

authors： Yasui K,Komiyama A

更新日期：2001-03-01 00:00:00

abstract：:The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...

journal_title：Cell biochemistry and function

authors： Muscari C,Bonafè F,Gamberini C,Giordano E,Lenaz G,Caldarera CM

更新日期：2006-11-01 00:00:00

abstract：:Beta-glucosidase activity was evaluated in situ by means of fluorogenic probes in normal human fibroblasts and fibroblasts from homozygous carriers of the Gaucher trait. Probe internalization, targeting to lysosomes and post-cleavage probe retention were the primary concerns. Internalization and targeting were attempt...

journal_title：Cell biochemistry and function

authors： Kohen E,Kohen C,Hirschberg JG,Santus R,Grabowski G,Mangel W,Gatt S,Prince J

更新日期：1993-09-01 00:00:00

abstract：:Effects of methotrexate (MTX) on mitochondrial oxidative metabolism and ion transport were studied. MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarat...

journal_title：Cell biochemistry and function

authors： Yamamoto N,Lopes LC,Campello AP,Klüppel ML

更新日期：1989-04-01 00:00:00

abstract：:The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This ...

journal_title：Cell biochemistry and function

authors： Irmak MK,Fadillioğlu E,Güleç M,Erdoğan H,Yağmurca M,Akyol O

更新日期：2002-12-01 00:00:00

abstract：:1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and 1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) are structural analogues of ceramide; inhibiting UDP-glucose : ceramide glucosyltransferase. After treatment with these synthetic ceramide analogues the expression of glucosphingolipid decreases, while ...

journal_title：Cell biochemistry and function

authors： Kovács P,Pintér M,Csaba G

更新日期：2000-12-01 00:00:00

abstract：:Functional irregularities due to damage after ischaemia-reperfusion vary depending upon the organs affected. High energy phosphates such as ATP and ADP are destroyed after ischaemia-reperfusion damage. Subsequently, protons and inorganic phosphates accumulate within the cells and the proton pumps such as adenosine tri...

journal_title：Cell biochemistry and function

authors： Ilhan N,Halifeoglu I,Ozercan HI,Ilhan N

更新日期：2001-09-01 00:00:00

abstract：:Endometrial cancer (EC) is the most common gynaecologic malignancy in western countries and has been reported to account for about 7% of female malignant tumours and 20% to 30% of female genital system malignant tumours. Accumulating evidence showed the expression of human trophoblast cell surface antigen 2 (Trop2) wa...

journal_title：Cell biochemistry and function

authors： Sun X,Xing G,Zhang C,Lu K,Wang Y,He X

更新日期：2020-03-01 00:00:00

abstract：:The dietary administration of selenium (sodium selenite; 4 p.p.m.) daily has been found to be highly effective in reducing the incidence of cancer induced by N-nitrosodiethylamine (DEN) in Wistar strain rats. Selenium treatment either before initiation, during initiation and selection/phenobarbital promotion phases of...

journal_title：Cell biochemistry and function

authors： Thirunavukkarasu C,Prince Vijeya Singh J,Thangavel M,Selvendiran K,Sakthisekaran D

更新日期：2002-12-01 00:00:00

abstract：:Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell-fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development....

journal_title：Cell biochemistry and function

authors： Li X,Li Y,Li S,Li H,Yang C,Lin J

更新日期：2020-08-25 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC-MSCs ...

journal_title：Cell biochemistry and function

authors： Zhang H,Zhang B,Tao Y,Cheng M,Hu J,Xu M,Chen H

更新日期：2012-12-01 00:00:00

abstract：:The levels of polyamines and their synthesizing enzymes in squamous cell carcinoma of prostate implanted in intact as well as castrated male rats were determined after certain hormonal manipulations. The tumour was found to grow with an identical rate in non-castrated and castrated rats. Polyamine content and activiti...

journal_title：Cell biochemistry and function

authors： Shukla GS,Singhal RL

更新日期：1985-07-01 00:00:00

abstract：:The p53 protein plays a critical role in suppression of tumour growth; its regulation is not fully understood. Leukaemia/lymphoma-related factor (LRF) promotes tumour cell growth. This study tests a hypothesis that LRF inhibits p53 expression in colon cancer cells. In this study, human colon cancer cell lines, LIM1215...

journal_title：Cell biochemistry and function

authors： Zhu M,Wang P,Feng F,Li MY

更新日期：2017-10-01 00:00:00

abstract：:Chemotherapeutic drugs that induce DNA damage have the potential to kill cancer cells, but DNA repair protects cells from damage-induced cell death. Thus, eliminating DNA repair is a potential approach to overcome cell drug resistance. In this study, we observed that the gene expression of C-terminal binding protein i...

journal_title：Cell biochemistry and function

authors： Yang L,Yang B,Wang Y,Liu T,He Z,Zhao H,Xie L,Mu H

更新日期：2019-10-01 00:00:00

abstract：:The new glass ionomer dental cement, ChemFil, was found to be moderately cytotoxic when freshly mixed in vitro. This was assessed by a reduction in fibroblast and macrophage counts following 24 h exposure to the material, and by alterations in enzyme levels and enzyme staining kinetics relative to control cultures. Te...

journal_title：Cell biochemistry and function

authors： Meryon SD,Browne RM

更新日期：1984-01-01 00:00:00