Abstract:
:Effects of methotrexate (MTX) on mitochondrial oxidative metabolism and ion transport were studied. MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate. MTX also has an inhibitory effect on the activities of the oxidation enzymes of NAD+-linked substrates without interfering with the oxidation systems of FAD-linked substrates. The effects of MTX could be interpreted as a consequence of a decrease in the ionic conductivity of the mitochondrial inner membrane.
journal_name
Cell Biochem Functjournal_title
Cell biochemistry and functionauthors
Yamamoto N,Lopes LC,Campello AP,Klüppel MLdoi
10.1002/cbf.290070208subject
Has Abstractpub_date
1989-04-01 00:00:00pages
129-34issue
2eissn
0263-6484issn
1099-0844journal_volume
7pub_type
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