Methotrexate: studies on cellular metabolism. II--Effects on mitochondrial oxidative metabolism and ion transport.

abstract：:The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine at three different doses (10, 50 and 100 mg kg(-1) bw) for five consecutive days. On the fifth day of treatment, mice ...

journal_title：Cell biochemistry and function

authors： Naghshvar F,Abianeh SM,Ahmadashrafi S,Hosseinimehr SJ

更新日期：2012-10-01 00:00:00

abstract：:Sexually-transmitted diseases (STD) can facilitate the progression of HIV-1 infection. Among them, as we have previously demonstrated, cervico-vaginal dysplasia-papillomavirus (HPV)-induced, together with HSV-2 co-infection, seems to be correlated with a more evident immunodepression in HIV-positive women, compared wi...

journal_title：Cell biochemistry and function

authors： Pugliese A,Andronico L,Gennero L,Pagliano G,Gallo G,Torre D

更新日期：2002-09-01 00:00:00

abstract：:During remodelling of pulmonary artery, marked proliferation of pulmonary artery smooth muscle cells (PASMCs) occurs, which contributes to pulmonary hypertension. Thromboxane A2 (TxA2) has been shown to produce pulmonary hypertension. The present study investigates the inhibitory effect of epigallocatechin-3-gallate (...

journal_title：Cell biochemistry and function

authors： Chowdhury A,Sarkar J,Chakraborti T,Chakraborti S

更新日期：2015-10-01 00:00:00

abstract：:Proliferating-cell nuclear antigen (PCNA), also known as cyclin, is synthesized in proliferative cells and recently was identified as DNA polymerase-delta auxiliary protein. In this paper, the association of PCNA to the proliferative cells of plants was analysed using both autoantibodies to PCNA obtained from a patien...

journal_title：Cell biochemistry and function

authors： Daidoji H,Takasaki Y,Nakane PK

更新日期：1992-06-01 00:00:00

abstract：:The biochemical and quantitative cytochemical assays of the activity of uridine diphosphoglucose dehydrogenase (UDPG-D) have produced perplexing results. It is now shown that the perplexity may be due to the possibility that the coenzyme (NAD) required for UDPG-D activity, may be acting as a substrate for a second deh...

journal_title：Cell biochemistry and function

authors： Mehdizadeh S,Bitensky L,Chayen J

更新日期：1991-04-01 00:00:00

abstract：:The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage measure. Indeed, before any investigation on the mechanism of action of different molecules, it is important to perform a cytotoxicity assay. Among the different...

journal_title：Cell biochemistry and function

authors： Pagano M,Faggio C

更新日期：2015-08-01 00:00:00

abstract：:Extracellular acylglycerols are hydrolysed by lipases active at the surface of intact fat cells isolated from rat or human adipose tissue. During short-term incubation, rat fat cells hydrolyse di-[3H]oleyl-[14C]glycerol at a rate of 70 +/- 7.7 mU/10(6) cells (mean +/- S.E.) versus 440 +/- 62 mU/10(6) cells for the hyd...

journal_title：Cell biochemistry and function

authors： Verine A,Boyer J

更新日期：1987-07-01 00:00:00

abstract：:Cyclophilin A (Cyp A), a member of the peptidyl-prolyl isomerase (PPI) family, may function as a molecular signalling switch. Comparative proteomic studies have identified Cyp A as a potential downstream target of protein kinase B (Akt). This study confirmed that Cyp A is a downstream effector of the phosphatidylinosi...

journal_title：Cell biochemistry and function

authors： Lin ZL,Wu HJ,Chen JA,Lin KC,Hsu JH

更新日期：2015-12-01 00:00:00

abstract：:The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(...

journal_title：Cell biochemistry and function

authors： Coskun ZM,Bolkent S

更新日期：2014-10-01 00:00:00

abstract：:Specific binding of a fully biologically active 125I-gonadotrophin releasing hormone (GnRH) to isolated anterior pituitary cells is time dependent, saturable and the concentration dependent binding curves exhibit positive cooperativity. Binding to intact or solubilized plasma membranes and an affinity purified GnRH re...

journal_title：Cell biochemistry and function

authors： Zolman JC,Theodoropoulos TJ

更新日期：1984-10-01 00:00:00

abstract：:This study was designed to investigate the role of HO-1 induction in prevention of thioacetamide (TAA)-induced oxidative stress, inflammation and liver damage. The changes in hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well as plasma arginine and asymmetric dimethylarginine (ADMA) levels were al...

journal_title：Cell biochemistry and function

authors： Develi-Is S,Bekpinar S,Kalaz EB,Evran B,Unlucerci Y,Gulluoglu M,Uysal M

更新日期：2013-03-01 00:00:00

abstract：:The activity and hormonal regulation of NAD- and NADP-linked isocitrate dehydrogenase (EC.1.1.1.41 and EC.1.1.1.42, respectively) in the brain, liver and kidney cortex of female rats of various ages was investigated. The activity of NAD-ICDH of brain was greater than extramitochondrial (-c) or intramitochondrial (-m) ...

journal_title：Cell biochemistry and function

authors： Yadav RN

更新日期：1988-07-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) receptors are present in pancreatic islets, though their regulation is unknown except for homologous desensitization. The modulation of binding of GRP to mouse pancreatic islets and INS-1 cells was studied. At 60 min (steady-state), total binding of [(125)I-Tyr(15)] GRP was 1.62 per cen...

journal_title：Cell biochemistry and function

authors： Kloss H,Wahl MA,Neye H,Verspohl EJ

更新日期：1999-12-01 00:00:00

abstract：:Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture o...

journal_title：Cell biochemistry and function

authors： Miranda DT,Batista VG,Grando FC,Paula FM,Felício CA,Rubbo GF,Fernandes LC,Curi R,Nishiyama A

更新日期：2008-12-01 00:00:00

abstract：:Several studies have highlighted the potential of leucine supplementation for the treatment of metabolic diseases including type 2 diabetes and obesity. Caloric restriction is a common approach to improve the health in diabetic and obese subjects. However, very few studies assessed the effects of leucine supplementati...

journal_title：Cell biochemistry and function

authors： Pedroso JA,Nishimura LS,de Matos-Neto EM,Donato J Jr,Tirapegui J

更新日期：2014-06-01 00:00:00

abstract：:A method for the quantification of energy consuming processes described by Siems et al. for reticulocytes and by Müller et al. for ascites tumour cells was applied to balance the ATP-consumption of isolated rat hepatocytes. On the basis of decreased coupled respiration rates following the specific inhibition of energy...

journal_title：Cell biochemistry and function

authors： Schneider W,Siems W,Grune T

更新日期：1990-10-01 00:00:00

abstract：:Diabetes induces oxidative stress in aged human and rat, although daily supplementation of vitamins C and E (VCE) can be beneficial to aged diabetic rats by reducing free radical production. The aim of the present study was to evaluate whether dietary VCE supplementation relieves oxidative stress in streptozotocin (ST...

journal_title：Cell biochemistry and function

authors： Özkaya D,Naziroğlu M,Armağan A,Demirel A,Köroglu BK,Çolakoğlu N,Kükner A,Sönmez TT

更新日期：2011-06-01 00:00:00

abstract：:The phospholipid profiles of the myocardium (from 10- and 18-day old chick embryos and 13-day old chick) and their in vitro response to the endogenous lipolytic enzymes (mainly of the phospholipase group) at pH 7.4 and 38 degrees C for 60 min were analyzed by TLC technology and densitometry. Cardiolipin (CL) was shown...

journal_title：Cell biochemistry and function

authors： Helmy FM,Aikins A,Hughes J,Belfield C,Juracka A

更新日期：2007-09-01 00:00:00

abstract：:Deficiency in neutrophils (neutropenia) caused by mutations in neutrophil elastase (NE, ELA2) has been extensively investigated. Monocytes and neutrophils are derived from a common myeloid progenitor; therefore, ELA2 mutations can also influence monocyte development. These effects have not been well described. In this...

journal_title：Cell biochemistry and function

authors： Lee HH,Sung MH

更新日期：2013-06-01 00:00:00

abstract：:Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardi...

journal_title：Cell biochemistry and function

authors： Pupure J,Fernandes MA,Santos MS,Moreno AJ,Kalvinsh I,Klusa V,Oliveira CR

更新日期：2008-09-01 00:00:00

abstract：:CD36, a multifunctional adhesion receptor e.g. for thrombospondin and collagen, as well as a scavenger receptor for oxidized low density lipoprotein, is expressed e.g. on platelets and monocytes. By this dual role it might be involved in early steps of atherosclerosis like the recruitment of monocytes and formation of...

journal_title：Cell biochemistry and function

authors： Pietsch A,Weber C,Goretzki M,Weber PC,Lorenz RL

更新日期：1995-09-01 00:00:00

abstract：:Voltage-gated Ca(2+) channels regulate cardiac automaticity, rhythmicity and excitation-contraction coupling. Whereas L-type (Cav 1·2, Cav 1·3) and T-type (Cav 3·1, Cav 3·2) channels are widely accepted for their functional relevance in the heart, the role of Cav 2·3 Ca(2+) channels expressing R-type currents remains ...

journal_title：Cell biochemistry and function

authors： Galetin T,Tevoufouet EE,Sandmeyer J,Matthes J,Nguemo F,Hescheler J,Weiergräber M,Schneider T

更新日期：2013-07-01 00:00:00

abstract：:The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentra...

journal_title：Cell biochemistry and function

authors： Pállinger E,Csaba G

更新日期：2007-09-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a common complication of premature birth that seriously affects the survival rate and quality of life among preterm neonates. Long non-coding RNAs (lncRNAs) have been implicated in many human diseases. However, the role of lncRNAs in the pathogenesis of BPD remains poorly understood...

journal_title：Cell biochemistry and function

authors： Bao TP,Wu R,Cheng HP,Cui XW,Tian ZF

更新日期：2016-07-01 00:00:00

abstract：:Melanin plays an important role in determining skin colour. Apoptosis of melanocytes and defect in melanin production cause vitiligo. Various studies have been conducted to treat the disease, but its treatment is still difficult. Therefore, this study aimed to investigate the effect of spermidine, which is known as an...

journal_title：Cell biochemistry and function

authors： Kang SH,Kim MM

更新日期：2021-01-25 00:00:00

abstract：:Thyroid cells fall into the type of cells functioning during continuous production of high H(2)O(2) concentrations. We studied the effect of H(2)O(2)-induced oxidative stress (0.1, 1.0 and 10.0 mM) on the activities of the key steps of iodide metabolism (uptake, oxidation and organification) in thyrocytes cultivated i...

journal_title：Cell biochemistry and function

authors： Nadolnik LI,Niatsetskaya ZV,Lupachyk SV

更新日期：2008-04-01 00:00:00

abstract：:UFD1L is the human homologue of the yeast ubiquitin fusion degradation 1 (Ufd1) gene and maps on chromosome 22q11.2 in the typically deleted region (TDR) for DiGeorge/velocardiofacial syndromes (DGS/VCFS). In yeast, Ufd1 protein is involved in a degradation pathway for ubiquitin fused products (UFD pathway). Several s...

journal_title：Cell biochemistry and function

authors： Amati F,Condò I,Conti E,Sangiuolo F,Dallapiccola B,Testi R,Novelli G

更新日期：2003-09-01 00:00:00

abstract：:In this study, the antimicrobial effects of monophosphazenes such as SM ipemphos and amphos were examined on bacterial and yeast strains. In addition, the biological effects of these compounds were tested on the lipid level of Saccharomyces cerevisiae and Candida albicans cells. The SM has an antimicrobial effect on t...

journal_title：Cell biochemistry and function

authors： Oztürk AI,Yilmaz O,Kirbağ S,Arslan M

更新日期：2000-06-01 00:00:00

abstract：:The main purpose of the present investigation was to study the effect of cloturin on aerobic glycolysis, endogenous and exogenous respiration and the level of ATP in both Ehrlich ascites carcinoma (EAC) and P388 murine leukaemia cells incubated in vitro. Also its effect on the level of total (T-SH) and non-protein (NP...

journal_title：Cell biochemistry and function

authors： Miko M,Krepelka J,Melka M

更新日期：1992-06-01 00:00:00

abstract：:Development and homeostasis of multicellular organisms require interactions between neighbouring cells. We recently established an in vitro model of cell-cell interaction based on a collagen vitrigel membrane. We have now examined the role of neural cells in retinal homeostasis by coculture of human retinal pigment ep...

journal_title：Cell biochemistry and function

authors： Ko JA,Hirata J,Yamane K,Sonoda KH,Kiuchi Y

更新日期：2015-01-01 00:00:00