Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells.

abstract：:Mitochondrial, endoplasmic reticular and plasma membrane fractions were isolated by a new method from control male Fischer 344 rats and rats given CCl4 by gavage. After 1 h of CCl4 treatment, rats were in glucose and pancreatic hormone balance but plasma levels of T3 and T4 were decreased 29 and 22%, respectively. Aft...

journal_title：Cell biochemistry and function

authors： Hemmings SJ,Pulga VB,Tran ST,Uwiera RR

更新日期：2002-03-01 00:00:00

abstract：:Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardi...

journal_title：Cell biochemistry and function

authors： Pupure J,Fernandes MA,Santos MS,Moreno AJ,Kalvinsh I,Klusa V,Oliveira CR

更新日期：2008-09-01 00:00:00

abstract：:Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is consid...

journal_title：Cell biochemistry and function

authors： Ustündağ B,Canatan H,Cinkilinç N,Halifeoğlu I,Bahçecioğlu IH

更新日期：2000-03-01 00:00:00

abstract：:The aim of this experimental study was to investigate the possible role of adenosine deaminase (AD) and xanthine oxidase (XO) in the pathogenesis of cisplatin-induced nephrotoxicity and the effect of erdosteine in decreasing the toxicity. The intraperitoneal injection of cisplatin (7 mg kg(-1) body weight) induced a s...

journal_title：Cell biochemistry and function

authors： Söğüt S,Kotuk M,Yilmaz HR,Ulu R,Ozyurt H,Yildirim Z

更新日期：2004-05-01 00:00:00

abstract：:Reduced and oxidized glutathione (GSH and GSSG), protein-bound glutathione, lipid peroxidation and antioxidant enzyme activities were determined in the erythrocyte lysates and membranes of type I and II alcoholics in order to clarify the effect of age-of-onset and the duration of the alcohol consumption on erythrocyte...

journal_title：Cell biochemistry and function

authors： Uçar G,Demir B,Uluğ B

更新日期：2005-01-01 00:00:00

abstract：:A method for the quantification of energy consuming processes described by Siems et al. for reticulocytes and by Müller et al. for ascites tumour cells was applied to balance the ATP-consumption of isolated rat hepatocytes. On the basis of decreased coupled respiration rates following the specific inhibition of energy...

journal_title：Cell biochemistry and function

authors： Schneider W,Siems W,Grune T

更新日期：1990-10-01 00:00:00

abstract：:Beta-glucosidase activity was evaluated in situ by means of fluorogenic probes in normal human fibroblasts and fibroblasts from homozygous carriers of the Gaucher trait. Probe internalization, targeting to lysosomes and post-cleavage probe retention were the primary concerns. Internalization and targeting were attempt...

journal_title：Cell biochemistry and function

authors： Kohen E,Kohen C,Hirschberg JG,Santus R,Grabowski G,Mangel W,Gatt S,Prince J

更新日期：1993-09-01 00:00:00

abstract：:Mesenchymal epithelial transition (C-MET) factor overexpression has been found in many types of cancer and has served as an important molecular target for therapeutic intervention. However, the role of C-MET in retinoblastoma remains largely unclear. The present study aimed to investigate the potential role and mechan...

journal_title：Cell biochemistry and function

authors： Dai H,Zeng W,Luo H

更新日期：2020-03-01 00:00:00

abstract：:During remodelling of pulmonary artery, marked proliferation of pulmonary artery smooth muscle cells (PASMCs) occurs, which contributes to pulmonary hypertension. Thromboxane A2 (TxA2) has been shown to produce pulmonary hypertension. The present study investigates the inhibitory effect of epigallocatechin-3-gallate (...

journal_title：Cell biochemistry and function

authors： Chowdhury A,Sarkar J,Chakraborti T,Chakraborti S

更新日期：2015-10-01 00:00:00

abstract：:Human adipose-derived stromal/stem cells (ASC) have immunomodulatory properties and the potential to differentiate into several cell lines, important for application in regenerative medicine. However, the contamination with dermal fibroblasts (FIB) can impair the beneficial effects of ASC in cell therapy. It is then e...

journal_title：Cell biochemistry and function

authors： Abreu de Melo MI,da Silva Cunha P,Coutinho de Miranda M,Faraco CCF,Barbosa JL,da Fonseca Ferreira A,Kunrath Lima M,Faria JAQA,Rodrigues MÂ,de Goes AM,Gomes DA

更新日期：2021-01-03 00:00:00

abstract：:One of the most damaging effects of reactive oxygen species (ROS) is lipid peroxidation, the end-product of which is malondialdehyde (MDA). This study was aimed to evaluate erythrocyte MDA levels during fracture healing in rats. Thirty male rats were used and the rats were divided into two groups to serve as controls ...

journal_title：Cell biochemistry and function

authors： Yeler H,Tahtabas F,Candan F

更新日期：2005-03-01 00:00:00

abstract：:Glioblastoma is one of the most malignant tumors and causes the high mortality in cancer patients. Currently, there is no highly efficient therapy against glioblastoma. Therefore, searching for a new molecular target to anti-glioblastoma therapy is urgent and necessary. In this study, we elucidated the role of Signal ...

journal_title：Cell biochemistry and function

authors： Zhao L,Li X,Su J,Wang Gong F,Lu J,Wei Y

更新日期：2020-07-01 00:00:00

abstract：:We examined the influence of chronic treatment with KN-93 (an inhibitor of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), 5 mg/kg given every other day for 4 weeks) on mean arterial pressure (MAP), urine protein and vascular reactivity in streptozotocin (STZ)-induced diabetes in Wistar Kyoto (WKY) and spontan...

journal_title：Cell biochemistry and function

authors： Yousif MH,Akhtar S,Walther T,Benter IF

更新日期：2008-03-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The in...

journal_title：Cell biochemistry and function

authors： Sharma U,Singh SK,Rajendra P

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of ferulic acid at different doses (50 mg kg(-1) alternative day and 50 mg kg(-1) daily) on the streptozotocin (STZ)-induced post-diabetes rat testicular damage. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). Rats treated wit...

journal_title：Cell biochemistry and function

authors： Roy S,Metya SK,Rahaman N,Sannigrahi S,Ahmed F

更新日期：2014-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC-MSCs ...

journal_title：Cell biochemistry and function

authors： Zhang H,Zhang B,Tao Y,Cheng M,Hu J,Xu M,Chen H

更新日期：2012-12-01 00:00:00

abstract：:It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR-2909 has emerged to regulate genes involve...

journal_title：Cell biochemistry and function

authors： Wani S,Kaul D

更新日期：2018-03-01 00:00:00

abstract：:The time-course of incorporation of NBD-cholesterol by macrophages (Ma) and lymphocytes (LY) obtained from untreated and thioglycollate-injected (thio) rats was investigated. NBD-cholesterol incorporation was also examined in Ma obtained from untreated rats and stimulated in vitro by lipopolysaccharide (LPS) and phorb...

journal_title：Cell biochemistry and function

authors： Portioli Silva EP,Peres CM,Roberto Mendonça J,Curi R

更新日期：2004-01-01 00:00:00

abstract：:Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signalling pathways including cervical cancer. However, the underlying mechanisms are still not well elucidated. Here, we assessed the effect of silibinin...

journal_title：Cell biochemistry and function

authors： Zhang Y,Ge Y,Chen Y,Li Q,Chen J,Dong Y,Shi W

更新日期：2012-04-01 00:00:00

abstract：:Cyclophosphamide (CP) has potential urotoxicity such as hemorrhagic cystitis (HC). 2-Mercaptoethane sulfonate (mesna) has been widely used as an effective agent against CP-induced cystitis, but significant HC has still been encountered clinically. In recent studies, mesna was shown to be more effective if combined wit...

journal_title：Cell biochemistry and function

authors： Sadir S,Deveci S,Korkmaz A,Oter S

更新日期：2007-09-01 00:00:00

abstract：:The effects of either radiation or hyperthermia on the differentiation potential of NG108-15, a neuroblastoma-glioma hybrid cell line, were studied. After radiation and hyperthermia, the outgrowth of neurites from NG108-15 cells was potentiated, and polarizing current and voltage pulses induced a distinct action poten...

journal_title：Cell biochemistry and function

authors： Sugihara M,Fujita Y,Enomoto K,Maeno T,Ishida T

更新日期：1994-06-01 00:00:00

abstract：:The vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease. Howeve...

journal_title：Cell biochemistry and function

authors： Schaun MI,Dipp T,Rossato Jda S,Wilhelm EN,Pinto R,Rech A,Plentz RD,Homem de Bittencourt PI,Reischak-Oliveira A

更新日期：2011-10-01 00:00:00

abstract：:The protective effects of betaine in ethanol hepatotoxicity were investigated in 24 female wistar albino rats. Animals were divided into three groups: control, ethanol and ethanol + betaine group. Animals were fed liquid diets and consumed approximately 60 diet per day. Rats were fed ethanol 8 kg(- 1) day(- 1). The et...

journal_title：Cell biochemistry and function

authors： Kanbak G,Inal M,Bayçu C

更新日期：2001-12-01 00:00:00

abstract：:The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 1...

journal_title：Cell biochemistry and function

authors： Yildirim A,Altinkaynak K,Aksoy H,Sahin YN,Akcay F

更新日期：2004-07-01 00:00:00

abstract：:Differences in metabolism of drugs can lead to severe toxicity or therapeutic failure. In addition to cytochrome P450 2D6, which plays a critical role in drug metabolism, ABCB1 encoded P-glycoprotein (PGP) is also an important determinant in drug bioavailability. The genes encoding these molecules are highly variable ...

journal_title：Cell biochemistry and function

authors： Correia C,Santos P,Coutinho AM,Vicente AM

更新日期：2009-06-01 00:00:00

abstract：:The p53 protein plays a critical role in suppression of tumour growth; its regulation is not fully understood. Leukaemia/lymphoma-related factor (LRF) promotes tumour cell growth. This study tests a hypothesis that LRF inhibits p53 expression in colon cancer cells. In this study, human colon cancer cell lines, LIM1215...

journal_title：Cell biochemistry and function

authors： Zhu M,Wang P,Feng F,Li MY

更新日期：2017-10-01 00:00:00

abstract：:The ataxia-telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy. We focused on the functions of AT...

journal_title：Cell biochemistry and function

authors： Liang N,He Q,Liu X,Sun H

更新日期：2019-04-01 00:00:00

abstract：:Cardiac hypertrophy is not only an adaptational state before heart failure but also is an independent risk factor for ischemia, arrhythmia, and sudden death. However, the direct effects of hypercholesterolemia on the myocardium and mechanisms are not completely understood. It has been demonstrated that peroxisome prol...

journal_title：Cell biochemistry and function

authors： Ren L,Li Y,Li Y,Tang R,Hu D,Sheng Z,Liu N

更新日期：2010-01-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, and thymidine phosphorylase (TP) is a regulator of angiogenesis. To investigate the biological activities of TP in ICC, we established human cholangiocarcinoma RBE cell lines overexpressing TP or silencing TP. Overexpression of TP en...

journal_title：Cell biochemistry and function

authors： Li S,Yang H,Li K,Fan G,Deng L,Xu C

更新日期：2020-08-01 00:00:00

abstract：:The activity and hormonal regulation of NAD- and NADP-linked isocitrate dehydrogenase (EC.1.1.1.41 and EC.1.1.1.42, respectively) in the brain, liver and kidney cortex of female rats of various ages was investigated. The activity of NAD-ICDH of brain was greater than extramitochondrial (-c) or intramitochondrial (-m) ...

journal_title：Cell biochemistry and function

authors： Yadav RN

更新日期：1988-07-01 00:00:00