Lipopolysaccharide enhances asymmetrical production of cytokines and nitric oxide by left and right cerebral cortical microglial cells in BALB/C mice.

Abstract:

:Lipopolysaccharide (LPS)-induced inflammatory factors production by the cerebral cortical glial cells in two sides of the murine brain are different. To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1β (IL-1β) and nitric oxide (NO) responses to LPS by microglial cells in the right and left cerebral cortices were examined. Primary microglial cells were isolated from BALB/C neonatal mice, treated with LPS (10 µg ml(-1) ) for 24 h and examined for IL-6, IL-1β and NO production. At untreated state, the levels of IL-6, IL-1β and NO showed no statistical difference between left and right. However, after LPS treatment, the levels of IL-6, IL-1β and NO for the right microglial cells was statistically significant higher than the left (P < 0·05). Our results denote that enhanced production of IL-6, IL-1β and NO after LPS treatment in microglia is directly proportional to their basal-state levels, and right cortical microglia produce higher levels of IL-6, IL-1β and NO than left cortical microglia.

journal_name

Cell Biochem Funct

authors

Xin G,Su Y,Gao YL,Zhang H,Wang GF,Li KS

doi

10.1002/cbf.1718

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

50-4

issue

1

eissn

0263-6484

issn

1099-0844

journal_volume

29

pub_type

杂志文章
  • The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes.

    abstract::While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3350

    authors: Muto A,Sugihara Y,Shibakawa M,Oshima K,Matsuda T,Nadano D

    更新日期:2018-08-01 00:00:00

  • Studies on the endogenous phospholipids of chick embryo myocardium and their in vitro hydrolysis by endogenous phospholipases during embryogenesis.

    abstract::The phospholipid profiles of the myocardium (from 10- and 18-day old chick embryos and 13-day old chick) and their in vitro response to the endogenous lipolytic enzymes (mainly of the phospholipase group) at pH 7.4 and 38 degrees C for 60 min were analyzed by TLC technology and densitometry. Cardiolipin (CL) was shown...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1422

    authors: Helmy FM,Aikins A,Hughes J,Belfield C,Juracka A

    更新日期:2007-09-01 00:00:00

  • Induction of differentiation by radiation and hyperthermia in neuroblastoma-glioma hybrid cells.

    abstract::The effects of either radiation or hyperthermia on the differentiation potential of NG108-15, a neuroblastoma-glioma hybrid cell line, were studied. After radiation and hyperthermia, the outgrowth of neurites from NG108-15 cells was potentiated, and polarizing current and voltage pulses induced a distinct action poten...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290120209

    authors: Sugihara M,Fujita Y,Enomoto K,Maeno T,Ishida T

    更新日期:1994-06-01 00:00:00

  • Effects of L-carnitine on neutrophil-mediated ischemia-reperfusion injury in rat stomach.

    abstract::Reactive oxygen metabolites play an important role in ischemia-reperfusion related gastric injury. Primary sources of reactive oxygen metabolites seem to be the xanthine/xanthine oxidase system and neutrophils accumulating within the reperfused tissue. Tissue myeloperoxidase activity is an important index of neutrophi...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1251

    authors: Derin N,Agac A,Bayram Z,Asar M,Izgut-Uysal VN

    更新日期:2006-09-01 00:00:00

  • C-MET-dependent signal transduction mediates retinoblastoma growth by regulating PKM2 nuclear translocation.

    abstract::Mesenchymal epithelial transition (C-MET) factor overexpression has been found in many types of cancer and has served as an important molecular target for therapeutic intervention. However, the role of C-MET in retinoblastoma remains largely unclear. The present study aimed to investigate the potential role and mechan...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3464

    authors: Dai H,Zeng W,Luo H

    更新日期:2020-03-01 00:00:00

  • Isocitrate dehydrogenase activity and its regulation by estradiol in tissues of rats of various ages.

    abstract::The activity and hormonal regulation of NAD- and NADP-linked isocitrate dehydrogenase (EC.1.1.1.41 and EC.1.1.1.42, respectively) in the brain, liver and kidney cortex of female rats of various ages was investigated. The activity of NAD-ICDH of brain was greater than extramitochondrial (-c) or intramitochondrial (-m) ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290060308

    authors: Yadav RN

    更新日期:1988-07-01 00:00:00

  • CrkI and p130(Cas) complex regulates the migration and invasion of prostate cancer cells.

    abstract::Prostate cancer metastasis is often associated with poor prognosis. The molecular coupling of the adaptor protein Crk to the docking protein p130(Cas) serves as a switch that regulates cell migration in several invasive cancer cells and Ack appears to act upstream of CrkII to modulate the cell motility. However, the p...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1797

    authors: Dai Y,Qi L,Zhang X,Li Y,Chen M,Zu X

    更新日期:2011-12-01 00:00:00

  • Proliferating cell nuclear antigen (PCNA/cyclin) in plant proliferating cells: immunohistochemical and quantitative analysis using autoantibody and murine monoclonal antibodies to PCNA.

    abstract::Proliferating-cell nuclear antigen (PCNA), also known as cyclin, is synthesized in proliferative cells and recently was identified as DNA polymerase-delta auxiliary protein. In this paper, the association of PCNA to the proliferative cells of plants was analysed using both autoantibodies to PCNA obtained from a patien...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290100209

    authors: Daidoji H,Takasaki Y,Nakane PK

    更新日期:1992-06-01 00:00:00

  • Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis.

    abstract::The MCF-7 human breast carcinoma cell line is widely used as a model system by breast cancer researchers and cell biologists investigating apoptosis. Since its establishment 30 years ago, from a patient with metastatic breast cancer, the original MCF-7 cell population has undergone genetic drift to such an extent that...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1106

    authors: Rintala-Maki ND,Abrasonis V,Burd M,Sutherland LC

    更新日期:2004-09-01 00:00:00

  • Myricetin ameliorates high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells.

    abstract::Endothelial dysfunction is recognized as the initial detectable stage of cardiovascular disease, a serious complication of diabetes. In this study, we evaluated effects of myricetin on high glucose (HG)-elicited oxidative damage in human umbilical vein endothelial cells (HUVECs). The cells were pre-incubated with myri...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3442

    authors: Aminzadeh A,Bashiri H

    更新日期:2020-01-01 00:00:00

  • Ethanol-induced hepatotoxicity and protective effect of betaine.

    abstract::The protective effects of betaine in ethanol hepatotoxicity were investigated in 24 female wistar albino rats. Animals were divided into three groups: control, ethanol and ethanol + betaine group. Animals were fed liquid diets and consumed approximately 60 diet per day. Rats were fed ethanol 8 kg(- 1) day(- 1). The et...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.926

    authors: Kanbak G,Inal M,Bayçu C

    更新日期:2001-12-01 00:00:00

  • Amelioration by menadione of the experimental chronic immune arthritis in the rabbit.

    abstract::The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290080406

    authors: Pitsillides AA,Blake SM,Glynn LE,Bitensky L,Chayen J

    更新日期:1990-10-01 00:00:00

  • Effect of serotonin-acting agents on the serotonin content of immune cells. A peculiar observation.

    abstract::The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentra...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1329

    authors: Pállinger E,Csaba G

    更新日期:2007-09-01 00:00:00

  • Histological changes in the liver of fetuses of alcohol-treated pregnant rats.

    abstract::In this study, immunolocalization of tenascin (TN), type IV collagen and histopathological changes in the liver of fetuses of pregnant Wistar albino rats treated with two doses of alcohol (1 and 5 g kg(-1) day(-1)) were determined. The samples of liver obtained from fetuses of rats on day 21 of gestation were evaluate...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1215

    authors: Koçkaya EA,Akay MT

    更新日期:2006-05-01 00:00:00

  • Localization of putative gonadotrophin releasing hormone receptor protein in the anterior pituitary.

    abstract::Specific binding of a fully biologically active 125I-gonadotrophin releasing hormone (GnRH) to isolated anterior pituitary cells is time dependent, saturable and the concentration dependent binding curves exhibit positive cooperativity. Binding to intact or solubilized plasma membranes and an affinity purified GnRH re...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.290020405

    authors: Zolman JC,Theodoropoulos TJ

    更新日期:1984-10-01 00:00:00

  • The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.

    abstract::This study was designed to investigate the role of HO-1 induction in prevention of thioacetamide (TAA)-induced oxidative stress, inflammation and liver damage. The changes in hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well as plasma arginine and asymmetric dimethylarginine (ADMA) levels were al...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2866

    authors: Develi-Is S,Bekpinar S,Kalaz EB,Evran B,Unlucerci Y,Gulluoglu M,Uysal M

    更新日期:2013-03-01 00:00:00

  • Modulation of gastrin-releasing peptide (GRP) receptors in insulin secreting cells.

    abstract::Gastrin-releasing peptide (GRP) receptors are present in pancreatic islets, though their regulation is unknown except for homologous desensitization. The modulation of binding of GRP to mouse pancreatic islets and INS-1 cells was studied. At 60 min (steady-state), total binding of [(125)I-Tyr(15)] GRP was 1.62 per cen...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0844(199912)17:4<229::AID-CBF83

    authors: Kloss H,Wahl MA,Neye H,Verspohl EJ

    更新日期:1999-12-01 00:00:00

  • Knockdown of Trop2 inhibits proliferation and migration and induces apoptosis of endometrial cancer cells via AKT/β-catenin pathway.

    abstract::Endometrial cancer (EC) is the most common gynaecologic malignancy in western countries and has been reported to account for about 7% of female malignant tumours and 20% to 30% of female genital system malignant tumours. Accumulating evidence showed the expression of human trophoblast cell surface antigen 2 (Trop2) wa...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3450

    authors: Sun X,Xing G,Zhang C,Lu K,Wang Y,He X

    更新日期:2020-03-01 00:00:00

  • Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes.

    abstract::Cardiac hypertrophy is characterized by remodeling of the extracellular matrix (ECM). Integrins are cell-surface molecules that link the ECM to the cellular cytoskeleton where they play roles as signaling molecules and transducers of mechanical force. To clarify the possible roles of integrins in cardiac myocyte hyper...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.988

    authors: Kim DJ,Park SH,Lim CS,Chun JS,Kim JK,Song WK

    更新日期:2003-03-01 00:00:00

  • Roles of phosphatidylinositol 3-kinase and phospholipase D in temporal activation of superoxide production in FMLP-stimulated human neutrophils.

    abstract::To determine the temporal roles of phosphatidylinositol 3-kinase (PI3-kinase) and phospholipase D (PLD) during human neutrophil activation stimulated by a chemotactic peptide, we examined the kinetics of these enzymes and related them to a neutrophil function (superoxide production). Both wortmannin and 2-(4-morpholin...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.898

    authors: Yasui K,Komiyama A

    更新日期:2001-03-01 00:00:00

  • Interleukin 6 protects H(2)O(2)-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation.

    abstract:OBJECTIVE:Hydrogen peroxide (H(2)O(2)) is a potent reactive oxygen species that causes cardiomyocytes injury. As an important cytokine, interleukin 6 (IL-6) has cardioprotective effects as it plays an essential role in the late phase of preconditioning. Our work is to investigate if IL-6 preconditioning has protective ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2820

    authors: Jia Y,Zhou F,Deng P,Fan Q,Li C,Liu Y,Fu X,Zhou Y,Xu X,Sun X

    更新日期:2012-07-01 00:00:00

  • Serum lipid profile paraoxonase and arylesterase activities in psoriasis.

    abstract::Psoriasis is a common chronic and recurrent inflammatory skin disease with unknown etiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.The aim of this work was to eva...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1553

    authors: Toker A,Kadi M,Yildirim AK,Aksoy H,Akçay F

    更新日期:2009-04-01 00:00:00

  • Cyclical mechanical stretch enhances degranulation and IL-4 secretion in RBL-2H3 mast cells.

    abstract::Mast cells are widely distributed in the body and affect their surrounding environment through degranulation and secretion of cytokines. Conversely, mast cells are influenced by environmental stimuli such as cyclical mechanical stretch (CMS), such as that induced by heartbeat and respiration. Peripherally distributed ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.2973

    authors: Komiyama H,Miyake K,Asai K,Mizuno K,Shimada T

    更新日期:2014-01-01 00:00:00

  • Up-regulation of semaphorin 4A expression in human retinal pigment epithelial cells by PACAP released from cocultured neural cells.

    abstract::Development and homeostasis of multicellular organisms require interactions between neighbouring cells. We recently established an in vitro model of cell-cell interaction based on a collagen vitrigel membrane. We have now examined the role of neural cells in retinal homeostasis by coculture of human retinal pigment ep...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.3082

    authors: Ko JA,Hirata J,Yamane K,Sonoda KH,Kiuchi Y

    更新日期:2015-01-01 00:00:00

  • Regulation of the G2/M phase of the cell cycle by sperm associated antigen 8 (SPAG8) protein.

    abstract::Sperm associated antigen 8 (SPAG8), a testis-specific protein produced during male germ cell differentiation, was isolated from a human testis expression library using antibodies found in the serum obtained from an infertile woman. It was found to have a close functional relationship with microtubules. In this study, ...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1574

    authors: Li R,Tang XL,Miao SY,Zong SD,Wang LF

    更新日期:2009-07-01 00:00:00

  • The use of erythrocyte fragility to assess xenobiotic cytotoxicity.

    abstract::The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage measure. Indeed, before any investigation on the mechanism of action of different molecules, it is important to perform a cytotoxicity assay. Among the different...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章,评审

    doi:10.1002/cbf.3135

    authors: Pagano M,Faggio C

    更新日期:2015-08-01 00:00:00

  • Pinealectomy increases oxidant damage in kidney and testis caused by hyperthyroidism in rats.

    abstract::Thyroid hormones regulate energy metabolism and act on mitochondria which are an important source of free radicals in the cell. The pineal gland activates antioxidant systems via melatonin secretion and thus has a protective function in body tissues. The present study was conducted to determine the oxidative damage ca...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1254

    authors: Mogulkoc R,Baltaci AK,Aydin L,Oztekin E,Tuncer I

    更新日期:2006-09-01 00:00:00

  • Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion.

    abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1294

    authors: Muscari C,Bonafè F,Gamberini C,Giordano E,Lenaz G,Caldarera CM

    更新日期:2006-11-01 00:00:00

  • House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells.

    abstract::Aberrant innate and adaptive immune responsed to allergens and environmental pollutants lead to respiratory allergic disease such as asthma. In this study, we focused on toll-like receptor-4 (TLR4) expressed on airway epithelium to identify house dust mite (HDM)-regulated allergic inflammation via TLR4 signaling pathw...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1697

    authors: Hongjia L,Qingling G,Meiying L,Weixuan W,Lihong Z,Yongsheng G,Yanli L,Jinxiang W,Liang D

    更新日期:2010-10-01 00:00:00

  • A microscopic study of kidney tissue in Familial Mediterranean Fever patients.

    abstract::Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in p...

    journal_title:Cell biochemistry and function

    pub_type: 杂志文章

    doi:10.1002/cbf.1286

    authors: Kiliçaslan SM,Ayvali C,Taştan H

    更新日期:2007-07-01 00:00:00