Molecular biology of smooth muscle.

abstract：:Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

journal_title：Journal of hypertension

authors： Williams B

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:To discuss changes during the past decades in the prevalence and in the patterns of detection, treatment and control of arterial hypertension in the general Belgian population aged 25-64 years. DESIGN:Data from two cross-sectional cardiovascular disease risk factor surveys of the general population aged 25-...

journal_title：Journal of hypertension

authors： De Henauw S,De Bacquer D,Fonteyne W,Stam M,Kornitzer M,De Backer G

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-dependent stiffening leads to reduced nitric oxide release, which...

journal_title：Journal of hypertension

authors： Lenders M,Hofschröer V,Schmitz B,Kasprzak B,Rohlmann A,Missler M,Pavenstädt H,Oberleithner H,Brand SM,Kusche-Vihrog K,Brand E

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

journal_title：Journal of hypertension

authors： Almoosawi S,Prynne CJ,Hardy R,Stephen AM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- ...

journal_title：Journal of hypertension

authors： Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Y

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:Strong evidence has secured aging as a powerful predictor of both cardiovascular risk and endothelial dysfunction, yet specific treatment is not available. We tested the hypothesis that vascular responsiveness to flavanol-rich cocoa increases with advancing age. We have previously shown that flavanol-rich co...

journal_title：Journal of hypertension

authors： Fisher ND,Hollenberg NK

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...

journal_title：Journal of hypertension

authors： Peters R,Booth A,Peters J

更新日期：2014-10-01 00:00:00

abstract：:Two formulations of felodipine, conventional and extended release (ER) tablets, were compared in a double-blind, crossover study of patients whose blood pressure was not being controlled using metoprolol 100 mg once daily. Nineteen patients with a supine diastolic blood pressure greater than or equal to 95 mmHg after ...

journal_title：Journal of hypertension

authors： McGrath BP,Langton D,Matthews PG,Syme S,Treloar K,McNeil JJ

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Orthostatic hypotension, postprandial hypotension, and carotid sinus hypersensitivity are hypotensive syndromes with high prevalence in older people. However, their pathophysiology and prognostic significance remain largely unknown. METHODS:In a retrospective cohort study of 313 consecutive patients visitin...

journal_title：Journal of hypertension

authors： Lagro J,Laurenssen NC,Schalk BW,Schoon Y,Claassen JA,Olde Rikkert MG

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:Several genome-wide scans recently accomplished in the ethnic Chinese revealed a number of candidate loci possibly contributing to essential hypertension, and some appeared to be replicable in 2q14-q23 and 5q32. The current study aimed to examine the linkage of qualitative and blood pressure quantitative tra...

journal_title：Journal of hypertension

authors： Ge D,Yang W,Huang J,Yao C,Xu X,Gan W,Zhao J,Liu D,Wang X,Duan X,Hui R,Shen Y,Yao Z,Qiang B,Gu D

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Patients with type-2 diabetes have a high prevalence of hypertension and show an elevated incidence of cardiovascular events and nephropathy. OBJECTIVES:Recent randomized trials of antihypertensive therapy providing information about cardiovascular and renal risk in diabetes, blood pressure goals and best s...

journal_title：Journal of hypertension

authors： Zanchetti A,Ruilope LM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To examine in a population with a high prevalence of hypertension, the association between six cardiovascular polymorphisms, arterial stiffness and medication use. METHODS:In this cross-sectional study (Hypertension: Interaction and Prevalence of POlymorphisms related to Cardiovascular Risk and the Associati...

journal_title：Journal of hypertension

authors： Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

更新日期：2009-01-01 00:00:00

abstract：:: Hypertension is a growing health concern worldwide. Established hypertension is a causative factor of heart failure, which is characterized by increased vascular resistance and intractable uncontrolled blood pressure. Hypertension and heart failure have multiple causes and complex pathophysiology but cellular immuni...

journal_title：Journal of hypertension

authors： Rai A,Narisawa M,Li P,Piao L,Li Y,Yang G,Cheng XW

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...

journal_title：Journal of hypertension

authors： Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:To review, on a genome-wide scale, a linkage result obtained in an earlier candidate gene analysis in this same study sample, and to look for other possible contributing genetic loci predisposing to hypertension in this population. DESIGN:An affected sibpair linkage study with highly polymorphic genetic mar...

journal_title：Journal of hypertension

authors： Perola M,Kainulainen K,Pajukanta P,Terwilliger JD,Hiekkalinna T,Ellonen P,Kaprio J,Koskenvuo M,Kontula K,Peltonen L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

journal_title：Journal of hypertension

authors： Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To investigate the association between long-term exposure to high-level urban traffic noise and blood pressure in preschool children. DESIGN:Normotensive children (n = 1542), aged 3-7 years and attending kindergartens, had their blood pressures and heart rate measured. Mean values of these circulatory variab...

journal_title：Journal of hypertension

authors： Regecová V,Kellerová E

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:To investigate the influence of angiotensin II (All) receptors in isolated hepatic nuclei on other genes regulated by All and to determine whether the function of these intracellular receptors is influenced by alterations in the endocrine renin system. METHODS:Nuclei were isolated from hepatic tissue of nor...

journal_title：Journal of hypertension

authors： Eggena P,Zhu JH,Sereevinyayut S,Giordani M,Clegg K,Andersen PC,Hyun P,Barrett JD

更新日期：1996-08-01 00:00:00

abstract：:Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Me...

journal_title：Journal of hypertension

authors： Nikolic SB,Sharman JE,Adams MJ,Edwards LM

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To investigate relationships between birth characteristics and blood pressure at age 20 years and to assess whether effects of birth weight on blood pressure are amplified from childhood to adulthood. DESIGN:A longitudinal study of 584 men and women from Adelaide, Australia, examined previously at 8 years an...

journal_title：Journal of hypertension

authors： Moore VM,Cockington RA,Ryan P,Robinson JS

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:A reduced cardiac output in chronic heart failure (CHF) evokes renal NaCl and water retention, and, therefore, activates mechanisms promoting natriuresis. Atrial natriuretic peptide (ANP) is one such factor. We hypothesized that another NaCl sensitive endogenous natriuretic factor, i.e., marinobufagenin (MBG...

journal_title：Journal of hypertension

authors： Fridman AI,Matveev SA,Agalakova NI,Fedorova OV,Lakatta EG,Bagrov AY

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, and hippocampal volumes, and have identified thinner cortices across the cortical mantle. METHOD:In the current study, we followed 96 participants enrolled in the Baltimore ...

journal_title：Journal of hypertension

authors： Gonzalez CE,Pacheco J,Beason-Held LL,Resnick SM

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:We hypothesized that downregulation of the antioxidant thioredoxin system contributes to oxidative stress in angiotensin II-induced hypertension. As oestrogen may protect against oxidative stress, we also evaluated whether the thioredoxin system, particularly in the heart, is differentially regulated between ...

journal_title：Journal of hypertension

authors： Ebrahimian T,He Y,Schiffrin EL,Touyz RM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that qualitative microalbuminuria (MAU) screening in a practice setting would identify non-diabetic hypertensive patients at high risk of developing cardiovascular disease. DESIGN:We enrolled general practitioners throughout Germany, who obtained histories, physical examinations, and...

journal_title：Journal of hypertension

authors： Agrawal B,Berger A,Wolf K,Luft FC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND METHOD:This study evaluated the effects of a linear block strength training programme on the parameters of cardiac remodelling in spontaneously hypertensive rats. Thirty-nine rats were equally distributed in four groups: normotensive sedentary, normotensive trained, hypertensive sedentary and hypertensiv...

journal_title：Journal of hypertension

authors： Perilhão MS,Krause Neto W,da Silva AA,Alves LLS,Antonio EL,Medeiros A,Rica RL,Serra AJ,Tucci PJF,Bocalini DS

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Hypertensive nephropathy is one of the major causes of chronic kidney disease (CKD). Bisphenol A (BPA) is associated with elevated blood pressure and urinary albuminuria. The aim of this study is to evaluate the association between serum BPA with the progression of CKD in patients with primary hypertension. ...

journal_title：Journal of hypertension

authors： Hu J,Wang Y,Xiang X,Peng C,Gao R,Goswami R,Zhou H,Zhang Y,Zhen Q,Cheng Q,Yang S,Li Q

更新日期：2016-02-01 00:00:00

abstract：:Using antibodies raised against angiotensin I and II, and high-performance liquid chromatography (HPLC) of plasma extracts, we have quantified six angiotensin peptides in venous (cubital vein) and arterial (brachial) plasma of normal male subjects. The concentrations of venous plasma (fmol/ml, mean +/- s.d., n = 29) f...

journal_title：Journal of hypertension

authors： Campbell DJ,Kladis A

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:We compared diurnal patterns of blood pressure in Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP), and analyzed the relationship between the change in diurnal patterns of blood pressure and target-organ damage in SHRSP. MATERIALS AND MET...

journal_title：Journal of hypertension

authors： Shimamura T,Nakajima M,Iwasaki T,Hayasaki Y,Yonetani Y,Iwaki K

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the reproducibility of pulse wave velocity (PWV) and augmentation index (AIx) measured using pulse wave analysis (PWA), prior to its use in large-scale clinical trials. METHODS:Arterial pressure waveforms were recorded and analysed using an established technique (Sphygm...

journal_title：Journal of hypertension

authors： Wilkinson IB,Fuchs SA,Jansen IM,Spratt JC,Murray GD,Cockcroft JR,Webb DJ

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:Whether the C-344T polymorphism of the aldosterone synthase gene is important for blood pressure control remains controversial. It has been proposed that an association between this polymorphism and blood pressure might be evident in elderly subjects. The aim of the present study was to test this hypothesis ...

journal_title：Journal of hypertension

authors： Casiglia E,Tikhonoff V,Mazza A,Rynkiewicz A,Limon J,Caffi S,Guglielmi F,Martini B,Basso G,Winnicki M,Pessina AC,Somers VK

更新日期：2005-11-01 00:00:00