The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication.


OBJECTIVE:To examine in a population with a high prevalence of hypertension, the association between six cardiovascular polymorphisms, arterial stiffness and medication use. METHODS:In this cross-sectional study (Hypertension: Interaction and Prevalence of POlymorphisms related to Cardiovascular Risk and the Association to Treatment Efficacy Study project), arterial stiffness was assessed by measuring pulse wave velocity (PWV) in 575 patients in one primary care practice. Patients were genotyped for the angiotensin II type 1 receptor [AGTR1 (A1166C)], angiotensinogen (M235T), angiotensin-converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 (C825T), and alpha-adducin (G460W) polymorphisms. Linear regression analyses were performed to assess the association between polymorphisms and PWV. RESULTS:Thirty percent of the patients (273 men, 302 women) had a carotid-femoral pulse wave velocity above 12 m/s and more than 60% of the patients had a carotid-femoral/carotid-radial PWV (CF/CR ratio) above 1. The CF/CR ratio was significantly associated with age, sex, dislipidemia, cardiovascular medication use and pulse pressure. After correction for these covariates, multivariate linear regression analyses showed that the C allele of AGTR1 was associated with a lower CF/CR ratio. This association was significantly influenced by cardiovascular medication use (P = 0.011), and showed a dose-allele effect, the CF/CR ratio decreasing with the number of C alleles (P = 0.04). CONCLUSION:In a primary care population, this study showed an independent protective dose-allele effect for the presence of C alleles of the AGTR1 polymorphism on PWV. This association, which was influenced by the use of cardiovascular medication, needs further investigations to identify the underlying mechanisms.


J Hypertens


Journal of hypertension


Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA




Has Abstract


2009-01-01 00:00:00












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    更新日期:2001-03-01 00:00:00

  • Insulin resistance determines phagocytic nicotinamide adenine dinucleotide phosphate oxidase overactivation in metabolic syndrome patients.

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    journal_title:Journal of hypertension

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    authors: Fortuño A,Bidegain J,San José G,Robador PA,Landecho MF,Beloqui O,Díez J,Zalba G

    更新日期:2009-07-01 00:00:00

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    abstract::Hypertension is associated with thickening of the wall of resistance vessels, but the cellular or genetic basis of this is unclear. Cell proliferation and intracellular alkalinization via increased Na+/H+ exchange are linked in the response of tissues to growth factors. To define a possible cellular basis for vascular...

    journal_title:Journal of hypertension

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    authors: Ng LL,Dudley C,Bomford J,Hawley D

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  • Kinetic study of the Ca2+ pump in erythrocytes from essential hypertensive patients.

    abstract::Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

    更新日期:1990-03-01 00:00:00

  • High sodium intake of children through 'hidden' food sources and its association with the Mediterranean diet: the GRECO study.

    abstract:OBJECTIVES:Sodium is the mineral that has been, mainly, linked to hypertension and cardiovascular disease. It is found naturally in many foods, but is also used in the food industry and manufacturing. Identification of total sodium intake, as well as 'hidden' sodium intake from food sources early in life is necessary. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Magriplis E,Farajian P,Pounis GD,Risvas G,Panagiotakos DB,Zampelas A

    更新日期:2011-06-01 00:00:00

  • A randomized study of quality of life during multiple risk factor intervention in treated hypertensive men at high cardiovascular risk.

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Agewall S,Wikstrand J,Dahlöf C,Fagerberg B

    更新日期:1995-12-01 00:00:00

  • An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population.

    abstract:OBJECTIVE:To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans. METHODS:All non-rare single nucleotide polymorphisms (SNPs) in AGT were identified by resequencing 24 individuals. Five tagging SNPs wer...

    journal_title:Journal of hypertension

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    authors: Wu X,Luke A,Rieder M,Lee K,Toth EJ,Nickerson D,Zhu X,Kan D,Cooper RS

    更新日期:2003-10-01 00:00:00

  • Blood pressure in professional male football players in Norway.

    abstract:OBJECTIVES:Scarce data exist on blood pressure (BP) and secondary effects in young athletes. Hence, we aimed to study prevalence of high BP (≥140/90 mmHg) and the association to arterial compliance, left ventricle mass and left atrium volume. METHODS:A Norwegian preparticipation cardiac screening of male professional ...

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    pub_type: 杂志文章


    authors: Berge HM,Gjerdalen GF,Andersen TE,Solberg EE,Steine K

    更新日期:2013-04-01 00:00:00

  • A reliable index for the prognostic significance of blood pressure variability.

    abstract:OBJECTIVES:This study presents a reliable index inspired by the total variability concept of real analysis in mathematics, called average real variability (ARV), for the prognostic significance of blood pressure variability (BPV) overcoming the pitfalls of the commonly used standard deviation (SD). BACKGROUND:Recent s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Mena L,Pintos S,Queipo NV,Aizpúrua JA,Maestre G,Sulbarán T

    更新日期:2005-03-01 00:00:00

  • Effect of anticipation and cuff inflation on blood pressure during self-measurement.

    abstract:BACKGROUND:Self-measurement of blood pressure (BP) is increasingly being used for the diagnosis of hypertension and to monitor BP at home. Whenever compared with ambulatory BP measurements, home BP values are frequently higher and less predictive for incident cardiovascular events. We hypothesized that this could be ca...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Gazzola K,Honingh M,Truijen J,Zuliani G,Van Den Born BH

    更新日期:2018-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Giubertoni E,Bertelli L,Bartolacelli Y,Origliani G,Modena MG

    更新日期:2013-03-01 00:00:00

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    abstract:OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Flevari P,Kalogeropoulou S,Drakou A,Leftheriotis D,Panou F,Lekakis J,Kremastinos D,Vlahakos DV

    更新日期:2013-06-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Matrougui K,Lévy BI,Schiavi P,Guez D,Henrion D

    更新日期:1998-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Girouard H,Chulak C,LeJossec M,Lamontagne D,de Champlain J

    更新日期:2003-01-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Nishikimi T,Koshikawa S,Ishikawa Y,Akimoto K,Inaba C,Ishimura K,Ono H,Matsuoka H

    更新日期:2007-05-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2007-04-01 00:00:00

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    更新日期:1984-04-01 00:00:00

  • Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


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    更新日期:2001-05-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Nyborg NC,Korsgaard N,Mulvany MJ

    更新日期:1986-08-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


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    更新日期:1995-10-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Cotter J,Cotter MJ,Oliveira P,Cunha P,Polónia J

    更新日期:2013-10-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章


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    更新日期:2004-02-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Nilsson PM

    更新日期:2012-06-01 00:00:00

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