Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect.

abstract：BACKGROUND:Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2. METHODS:We performed a large association study of polymorphisms in this region with blood pressure modulatio...

journal_title：Journal of hypertension

authors： Kamide K,Kokubo Y,Yang J,Tanaka C,Hanada H,Takiuchi S,Inamoto N,Banno M,Kawano Y,Okayama A,Tomoike H,Miyata T

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Studies directly comparing the associations of intima-media thickness with blood pressure (BP) on manual sphygmomanometric blood pressure measurement (SBPM) and 24-h ambulatory blood pressure measurement (ABPM) are scarce and have a cross-sectional design. METHODS:At baseline, we measured systolic and diasto...

journal_title：Journal of hypertension

authors： Dechering DG,Wizner B,Adiyaman A,Nawrot T,Jin Y,Richart T,Kuznetsova T,Struijker-Boudier HA,Thien T,Staessen JA

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:High blood pressure is common in acute stroke and is associated independently with poor outcome. Lowering blood pressure might improve outcome, provided it does not reduce cerebral blood flow in the presence of dysfunctional cerebral autoregulation. METHODS:We performed a systematic review of clinical contro...

journal_title：Journal of hypertension

authors： Sare GM,Gray LJ,Bath PM

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...

journal_title：Journal of hypertension

authors： Holness MJ,Sugden MC

更新日期：1998-03-01 00:00:00

abstract：AIM:We determined whether left ventricular hypertrophy (LVH) which exceeds that predicted from workload [inappropriate LV mass (LVM(inappr))] is associated with reduced left ventricle (LV) systolic chamber function independent of and more closely than absolute or indexed left ventricular mass (LVM). METHODS:In 626 ran...

journal_title：Journal of hypertension

authors： Libhaber CD,Norton GR,Maseko MJ,Majane OH,Millen AM,Maunganidze F,Michel FS,Brooksbank R,Libhaber E,Sareli P,Woodiwiss AJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS:We investigated the autonomic cardiovascular control of 15 women w...

journal_title：Journal of hypertension

authors： Jacob G,Barbic F,Glago M,Dipaola F,Porta A,Furlan R

更新日期：2018-10-01 00:00:00

abstract：:: In 2010, 1.4 billion people globally had hypertension, with 14% controlled to systolic blood pressure (SBP, mmHg) below 140, which contributes to 18 million cardiovascular deaths annually. Recent hypertension guidelines endorsed SBP targets below 130 or lower for all or some hypertensive patients to reduce cardiovas...

journal_title：Journal of hypertension

authors： Egan BM,Kjeldsen SE,Grassi G,Esler M,Mancia G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

journal_title：Journal of hypertension

authors： Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

journal_title：Journal of hypertension

authors： Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To estimate the arterial blood pressure, left ventricular function and insulin secretion in alcoholics. DESIGN:We examined hospitalized patients between the second and seventh day of acute alcohol withdrawal and after a month of abstinence by 24 h ambulatory blood pressure monitoring, a standard oral glucose...

journal_title：Journal of hypertension

authors： Rajzer M,Kawecka-Jaszcz K,Czarnecka D,Dragan J,Betkowska B

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip). METHODS:We simultaneously monitored 24-h ambulatory blood pressure and measured physical activity by actigraphy in 434 patients. Blood pressure w...

journal_title：Journal of hypertension

authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

更新日期：2000-04-01 00:00:00

abstract：:Recent evidence suggests that a considerable proportion of plasma angiotensin is generated not in blood but in peripheral tissues. Through the measurement of angiotensin peptides and renin in the plasma of 11 anephric subjects, we have investigated whether kidney-derived renin, or some other tissue mechanism for angio...

journal_title：Journal of hypertension

authors： Campbell DJ,Kladis A,Skinner SL,Whitworth JA

更新日期：1991-03-01 00:00:00

abstract：:Measurements of exchangeable sodium, arterial pressure and plasma concentrations of active renin, angiotensin II, aldosterone, sodium and potassium were made in 35 hypertensive patients with renal artery stenosis, 30 having unilateral renal arterial lesions. Plasma urea was below 7 mmol/l in 24 of the patients with un...

journal_title：Journal of hypertension

authors： McAreavey D,Brown JJ,Cumming AM,Davies DL,Fraser R,Lever AF,Mackay A,Morton JJ,Robertson JI

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:In arteries, agonists such as acetylcholine release an endothelium-derived hyperpolarizing factor (EDHF) that is neither nitric oxide nor prostacyclin. OBJECTIVES:To examine the responses to acetylcholine in segments of forearm veins from patients with chronic renal failure who either had never received dia...

journal_title：Journal of hypertension

authors： Martinez-León JB,Segarra G,Medina P,Vila JM,Lluch P,Peiró M,Otero E,Lluch S

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Functional sex differences are described in several vascular beds. In the case of renal vessels, sex differences could influence processes like regulation of blood pressure and ion balance. Angiotensin II and nitric oxide are important regulators of renal vascular tone. Females have higher nitric oxide syntha...

journal_title：Journal of hypertension

authors： Viegas VU,Liu ZZ,Nikitina T,Perlewitz A,Zavaritskaya O,Schlichting J,Persson PB,Regitz-Zagrosek V,Patzak A,Sendeski MM

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...

journal_title：Journal of hypertension

authors： Baulmann J,Homsi R,Uen S,Düsing R,Fimmers R,Vetter H,Mengden T

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To assess the effects of acute exposure to simulated high altitude on baroreflex control of mean cerebral blood flow velocity (MCFV). PATIENTS AND METHODS:We compared beat-to-beat changes in RR interval, arterial blood pressure, mean MCFV (by transcranial Doppler velocimetry in the middle cerebral artery), e...

journal_title：Journal of hypertension

authors： Passino C,Cencetti S,Spadacini G,Quintana R,Parker D,Robergs R,Appenzeller O,Bernardi L

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of the haem oxygenase-carbon monoxide (CO) system to renal vascular tone in normotensive Wistar rats and in the stroke-prone spontaneously hypertensive rats (SHR-SPs). METHODS:An isolated perfused rat kidney preparation was used in which perfusion pressure/phenylephrine dose-vaso...

journal_title：Journal of hypertension

authors： Mustafa MR,Johns EJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Various studies have suggested that a delay in the time between diagnosing hypertension and its correct control (D-C, diagnostic-control time) is linked to a worse prognosis. The aim of this study was to examine the relationship between D-C time and all-cause mortality, or the incidence of cardiovascular even...

journal_title：Journal of hypertension

authors： Martín-Fernández M,Vinyoles E,Real J,Soldevila N,Muñoz MÁ,Del-Val JL,Verdú JM,Domingo M,Mundet X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS:To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, u...

journal_title：Journal of hypertension

authors： van Esch JH,van Gool JM,de Bruin RJ,Payne JR,Montgomery HE,Hectors M,Deinum J,Dive V,Jan Danser AH

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Microalbuminuria (MA) is a marker of adverse outcome in hypertension. The aim of this study was to investigate the association of MA with cardiovascular risk factors and glomerular hyperfiltration in the early stage of hypertension and to assess its predictive value for the development of sustained hypertensi...

journal_title：Journal of hypertension

authors： Palatini P,Mormino P,Mos L,Mazzer A,Dorigatti F,Zanata G,Longo D,Garbelotto R,De Toni R,Graniero G,Pessina AC,HARVEST Study Group.

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Nifedipine, an L-type calcium channel blocker, is widely used in the treatment of hypertension and coronary heart diseases, and also exhibits an antiplatelet activity. Activation of peroxisome proliferator-activated receptors (PPARs; α, β/δ, and γ) inhibits the platelet aggregation. Therefore, the purpose of ...

journal_title：Journal of hypertension

authors： Shih CY,Lin MH,Fan HC,Chen FC,Chou TC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secreti...

journal_title：Journal of hypertension

authors： van Twist DJ,Houben AJ,de Haan MW,de Leeuw PW,Kroon AA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation. OBJECTIVE:To test whether antihypertensive treatment with the angiotensin converting enzyme inhibitor lisinopril can improve vasodilatation in response to endothelium-dependent agonists in essential hypertensiv...

journal_title：Journal of hypertension

authors： Taddei S,Virdis A,Ghiadoni L,Mattei P,Salvetti A

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide family, is involved in maintaining circulatory homeostasis and is a protective factor of heart and vessel. Here, we investigated the effects of IMD on cardiac hypertrophy in vivo and in vitro and explored the mechanisms involve...

journal_title：Journal of hypertension

authors： Lu WW,Zhao L,Zhang JS,Hou YL,Yu YR,Jia MZ,Tang CS,Qi YF

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The effects of aspirin in subjects without cardiovascular disease are controversial. In the intensively treated patients of the Hypertension Optimal Treatment (HOT) Study, randomization to low-dose aspirin (75 mg daily) versus placebo significantly reduced cardiovascular events (-15%) and myocardial infarcti...

journal_title：Journal of hypertension

authors： Zanchetti A,Hansson L,Dahlöf B,Julius S,Ménard J,Warnold I,Wedel H,HOT Study Group.

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:In the nineteenth century, prior to the introduction of the cuff sphygmomanometer, stiffening of arteries was recognized as an indicator of vascular ageing and cardiovascular risk. Through the twentieth century, views on vascular ageing came to focus on brachial blood pressures and on occlusive atherosclerot...

journal_title：Journal of hypertension

authors： Safar ME,Nilsson PM

更新日期：2013-05-01 00:00:00

abstract：:Behavioral stress and high dietary salt have been reported to increase blood pressure additively in non-human primates. This study was designed to replicate this phenomenon and to assess neuroendocrine correlates and responses to two commonly used antihypertensives, a beta-adrenoceptor blocker and a thiazide diuretic....

journal_title：Journal of hypertension

authors： Turkkan JS,Goldstein DS

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVES:To investigate the mechanism of angiotensin II-induced apoptosis in cultured cardiomyocytes by determining which receptor subtype is involved, and what is the relationship between intracellular Ca2+ changes and apoptosis. DESIGN AND METHODS:Neonatal rat cardiomyocytes were pretreated with either the AT1 ant...

journal_title：Journal of hypertension

authors： Goldenberg I,Grossman E,Jacobson KA,Shneyvays V,Shainberg A

更新日期：2001-09-01 00:00:00

abstract：:The effects of i.v. injection of intact digoxin antibody (0.3 mg/rat) and of its Fab fragment (40 mg/rat) on blood pressure, cardiac output and total peripheral resistance were measured in conscious spontaneously hypertensive and deoxycorticosterone hypertensive rats. In vitro findings showed that Fab fragment bound r...

journal_title：Journal of hypertension

authors： Mann JF,Miemietz R,Ganten U,Ritz E

更新日期：1987-10-01 00:00:00